- From a drug label14%
- From a trial programme14%
- From a published study4%
- From a clinical guideline4%
- Community convention40%
- From a withdrawn label0%
- No source24%
225 compounds. 91 follow a schedule nobody tested. Click any underlined number to see who else uses it.
Two different questions
Whether to take breaks, and how long those breaks should be. The first sometimes has an answer. The second almost never does.
The badge on each row tells you where the schedule came from, not whether it works.
Taken continuously
81 listedNo breaks. Usually because the trials tested it that way, and stopping undoes the effect.
Set by the prescription
Not cycled
Not cycled
Applied daily, with no established course
Not cycled in the trials
Set by the prescription
Continuous, for years in the trials
Studied as daily dosing for up to
Given for the length of the trial, with no cycling
Not cycled
Continuous in the one human trial
Set by the prescription
Not cycled. Infused every in the trials
Not cycled
Continuous, with the dose reassessed rather than paused
Not cycled in the trials
Not cycled in the trials
Set by the prescription
Not cycled in the trials
Not cycled
Set by the prescription
Set by the prescription
Taken continuously, with no planned break
Continuous weekly dosing
Not cycled in the trials
Continuous in the trials
Taken continuously, with no planned break
Not cycled
Not cycled
Not cycled
Set by the prescription
Continuous alongside testosterone therapy; a defined cycle in fertility use
Not cycled
Not cycled in medical use
Studied as daily dosing for up to
Continuous, since the approved use is a permanent deficiency
Not cycled in the trials
Continuous, for about five years in the trials
Not cycled
Set by the prescription
Not cycled
Set by the prescription
Not cycled in the trials
Not cycled
Not cycled in the trials
Not cycled in the research. Commonly cycled by users anyway
Not cycled
Continuous in the trials
Continuous in the trials
Not cycled
Not cycled
Not cycled in the trials
Not cycled
Not cycled
Not cycled
Not cycled in the trials
Not cycled in the trials
Not cycled
Not cycled
Not cycled, but the label caps it: one dose in 24 hours, and no more than 8 in a month
Applied daily, with no established course length
Not cycled in the trials
Not cycled
Not cycled
Not cycled
Not cycled
Not cycled
Not cycled in the trials
Not cycled
Continuous, for years at a time in the trials
Continuous daily use, with no planned break
Not cycled
Continuous daily dosing, studied to 24 weeks
Not cycled
Not cycled
Continuous, until the disease progresses
Continuous in the trials
Continuous in the trials
Not cycled
Not cycled in the trials
Not cycled in the trials
Taken in courses
67 listedA defined run, then a long gap. Common for the bioregulators and the Russian-tradition peptides.
A 28-day daily course is what has been studied
Daily for , then a long break, repeated a few times a year
Daily for , then a long break, repeated a few times a year
Commonly run in blocks around an injury, then stopped
Commonly run in blocks around an injury, then stopped
Courses of , repeated two or three times a year
Daily for , then a long break
Courses of , repeated two or three times a year
10 to 21 day courses of daily infusion, repeated after roughly two months
Courses of , repeated two or three times a year
Set by the prescription
Daily for , then a long break, repeated a few times a year
Daily for , then a long break, repeated a few times a year
Courses of , repeated two or three times a year
Five-day courses, and not beyond about six courses
Courses of , repeated two or three times a year
Given in 10-day courses, repeated after a break
Daily for , then a long break
Daily for , then a long break, repeated a few times a year
Courses of , repeated two or three times a year
21 days in the one human study
Daily for , then a long break, repeated a few times a year
Daily for , then a long break, repeated a few times a year
Given within a treatment cycle, roughly 7 to 12 days, then stopped
Given every other day in courses of about 10 doses
Taken in daily, 4-8 wk courses
Daily for , then a long break, repeated a few times a year
Daily for , then a long break
Taken in daily, short courses
The approved implant is one every 2 months, about 3 a year
A loading phase, then maintenance, rather than a cycle
Courses of , repeated two or three times a year
Taken in courses, usually , with breaks between
Taken in courses, usually , with breaks between
Commonly given as a course of infusions, then occasional top-ups
Usually taken in courses of about 8 weeks, then stopped
Courses of , repeated two or three times a year
Daily for , then a long break
Commonly run in blocks, like BPC-157
Oral use is continuous with a review at 3 to 6 months; the injectable form is a weekly course
Daily for , then a long break, repeated a few times a year
Courses of , repeated two or three times a year
Daily for , then a long break
Taken in courses, usually , with breaks between
Taken in courses, usually , with breaks between
Courses of , repeated two or three times a year
Daily for , then a long break, repeated a few times a year
Daily for , then a long break, repeated a few times a year
Daily for , then a long break, repeated a few times a year
Daily for , then a long break, repeated a few times a year
Commonly a loading period of 4 to 6 weeks, then less often, then stopped
Daily, usually for up to two years, then a different drug afterwards
Daily for , then a long break
Daily for , then a long break, repeated a few times a year
Taken in 10-day courses
Courses of , repeated two or three times a year
Given in courses, usually a few weeks at a time
Given as a defined course, typically twice weekly over months
Daily for , then a long break, repeated a few times a year
Given through a 26-week weight-loss phase, then a 26-week holding phase
Daily for , then a long break, repeated a few times a year
Daily for , then a long break
Courses of , repeated two or three times a year
Taken in courses
Daily for , then a long break, repeated a few times a year
Daily for , then a long break, repeated a few times a year
Daily for , then a long break, repeated a few times a year
Cycled with breaks
18 listedBlocks on and blocks off. This is where the invented schedules live.
Commonly cycled
Commonly cycled, usually and 4 off
Commonly cycled, usually and 4 off
Commonly cycled
Commonly cycled
Commonly cycled, usually and 4 off
Commonly cycled, usually and 4 off
Pulsed, not continuous. How often you give it decides whether it switches the system on or off
Cycled, and the only one here where the break has actually been measured
Used around training rather than on a cycle
Commonly run in 4 week blocks
Commonly cycled, often quoted as 5 days on and 2 days off, or and 4 off
Each half is cycled on its own schedule, usually and 4 off
Should not be given continuously. Response fades within about two weeks of twice-daily dosing
Usually spaced rather than daily. Trials have deliberately dosed every other day
Usually run nightly in 3 to 6 month courses at clinics, with periodic breaks
Commonly cycled
Each half is cycled on its own schedule, usually and 4 off
No established schedule
59 listedNobody has worked out whether to take breaks, or how long they should be.
No established schedule
No schedule exists. Development was halted
No established pattern
No schedule exists
Not established
Not established
Set by the prescription
No established pattern
No established pattern. Community use is often 8 weeks on, 8 weeks off
No established schedule
Not established for the blend
No schedule. Development stopped in April 2025
No established pattern
No established pattern
No established schedule
No established schedule
No established pattern
No established schedule
Not established
No established pattern
Not established
Not established
Not established
Not established
No established schedule
Not established
No established schedule
Not established
No established schedule
No established schedule
No established schedule
Set by the prescription
Not established
No established schedule
No established schedule
No established pattern, since the blend has never been studied
No established schedule
No established schedule
No established schedule
No established schedule
No established schedule
No established schedule
Regular use is the problem, not the solution
No established pattern
Not established
No established schedule
Not established for the blend
No established pattern
Not established for the blend
Not established
Not established
Not established
Not established
Not established
Not established
No established schedule
No established pattern
Not established
No established schedule
Sixty-four percent of cycling advice was invented
Repeated widely. Traced to no study.
Nobody has established one, and sources disagree.
Someone actually tested this.
The reason to cycle is often real. The schedule almost never is. Ipamorelin is the clearest case: sustained exposure to a ghrelin-receptor peptide blunts the growth hormone response to a later dose, and that has been shown in people. No published study has tested any on and off pattern at all.
Receptors stop listening
Keep hitting the same receptor and the response fades. This is real, measured in people for the growth hormone peptides, and it is the honest reason to take a break. It says nothing about how long a break should be.
Nobody funded the question
Testing a cycling schedule needs a long trial with several arms, and no company will pay for it on a compound they cannot sell. So the schedules come from forums, and then from vendors quoting forums.
Approved drugs are usually not cycled
Semaglutide, tirzepatide and the rest are taken continuously, because the trials tested them that way. Stopping brings the weight back. Cycling is mostly a research-peptide idea.
Does this tell me when to take breaks?
No. It tells you what people do and whether anyone has tested it. For most compounds here nobody has, and we say so rather than repeating a number.
Where does "8 weeks on, 4 weeks off" come from?
Not from a study. It is a convention borrowed from bodybuilding, applied to peptides afterwards. No published trial has compared it to any other schedule for any compound on this page.
If the schedule is made up, is cycling pointless?
Not necessarily. For the growth hormone peptides the reason is real: the response to a dose falls if you never stop. What is missing is the number, not the principle.
Why are the approved drugs not cycled?
Because they were tested continuously and that is how they work. With semaglutide, most of the weight comes back within a year of stopping, so the question is whether to stay on it rather than when to pause.
This page describes what people do. It does not tell you what to do.