Adropin_Dosage, benefits & legal status
Also known as ENHO peptide, energy homeostasis associated protein
A metabolic hormone measured in blood, sold as though the measurement were a treatment.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Adropin?
Plain language first. The technical label stays, but it never stands alone.Overview
A hormone that shows up low in people with metabolic problems. Nobody has tested whether giving it to people fixes anything.
Adropin, the secreted peptide product of the ENHO gene, implicated in energy homeostasis and insulin sensitivity. Human literature is predominantly observational, reporting associations between circulating concentrations and metabolic phenotypes. No published human administration trial.
What it's used for
Sold for metabolic health, insulin sensitivity and fatty liver on the basis of association studies.
How does Adropin work?
What it does in the body, and where.Adropin belongs to a group of compounds where the research question and the sales pitch are different questions.
- 01It is a secreted peptide from the ENHO geneReported to be involved in energy homeostasis, with animal work linking it to insulin sensitivity and fuel selection.
- 02Most human data is observationalStudies measure blood adropin in people with and without a condition and report a difference. That establishes an association and cannot show which way the arrow points.
- 03Low levels in a disease do not mean topping it up treats the diseaseThis is the recurring error across the marker peptides in this category. A level can fall because of a condition rather than causing it, in which case restoring the number changes nothing.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Insulin sensitivity and glucose handlingEarly research
- Fatty liver diseaseEarly research
- Cardiovascular and endothelial functionEarly research
The published record
Papers and trials about Adropin
232 papers tagged human · 181 not reviews or lab · 12 clinical trial publications
9 registered trials · none with posted results
Furthest stage reached: Published trials only, 12 clinical trial publications, no phased trial registered
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count. 428 papers and 9 trials indexed in detail.
At a glance
Four things to know about Adropin
Evidence
Category
Weight loss and metabolic
Common vial
Varies
Half-life
Nothing published
How much, and do you cycle it?
The range, and whether you take breaks.Research only, not established. Not established No range
No schedule has been studied for this compound in people.
Nothing publishedNo figure
No half-life has been published for administered adropin in people.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Adropin keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Solubility, computed: 23% charged residues, 40% hydrophobic. Base may help.
A first-pass rule from peptide manufacturers' guidance. It does not account for disulfide bridges, salt form or how the powder was dried, and it predicts what should be easy rather than what will happen in your vial.
Who should avoid it
- Pregnancy or breastfeeding
- Diabetes or any diagnosed metabolic condition, where an untested peptide is not a substitute for treatment
- Anyone who wants established safety data, because none exists for this compound in humans
Stop and get help
- Signs of an allergic reaction, including spreading hives, facial or throat swelling, or trouble breathing
- Redness, heat, or pus at the injection site, which can signal infection
- Anything unusual, since there is no known safety profile to compare it against
Common effects
- Unknown. No study has recorded what this commonly causes in people
- Redness, soreness, or a small bump at the injection site
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Adropin approved?
And where the numbers on this page come from.No. Adropin is not approved for any use, anywhere. It is sold labeled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin (subcutaneous)
- Checked24 August 2026
- DoseNo dose has been established in people.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesNone traced yet.
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
You can compare this against the whole library, or read how to check a seller.
If you're weighing Adropin, it's worth reading AT-7687, Irisin, and Setmelanotide (Imcivree) in the same class.
A metabolic hormone measured in blood, sold as though the measurement were a treatment.
- Dose
- Research only
- How often
- Not established
An experimental weekly shot that blocks the GIP receptor, the opposite of what tirzepatide does.
- Dose
- 25 or 50 mg weekly (phase 2 doses)
- How often
- Weekly
The exercise-in-a-pill myokine, and a decade-long argument about whether the tests for it work.
- Dose
- Research only
- How often
- Not established
An approved daily shot for rare genetic forms of obesity.
- Dose
- 2 up to 3 mg per day (start low, increase slowly)
- How often
- Daily
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence
Beyond these, 437 records are indexed. Browse the records