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Semaglutide is a GLP-1 receptor agonist, a lab-made copy of a natural gut hormone your body releases after eating. In plain terms: it flips on your 'I'm full' signal, so you feel satisfied sooner, eat less, and your blood sugar steadies. It is the active drug in Ozempic and Wegovy.
Build & hold muscleBPC-157 is a synthetic chain of 15 amino acids based on a protective protein found in stomach acid. In plain terms: it seems to speed the body's own repair signals, especially for blood vessels and connective tissue, which is why people use it after injuries, though almost all evidence is from animals.
Weight lossRetatrutide is a triple agonist that switches on three hormone receptors at once: GLP-1, GIP, and glucagon. In plain terms: it copies three of your natural 'I'm full' and fat-burning signals together, which is why it drives some of the largest weight-loss numbers seen in trials. It is still experimental.
Recovery & muscleCJC-1295 without DAC (also called Mod GRF 1-29) is the short-acting version of the same GHRH analog. In plain terms: it gives a quick pulse of growth hormone closer to your body's natural rhythm, then clears fast, so it is usually paired with ipamorelin.
Recovery & muscleIpamorelin is a growth hormone secretagogue, specifically a ghrelin-receptor agonist (a GHRP). In plain terms: instead of injecting growth hormone, it signals your pituitary to release a clean pulse of your own, without much effect on hunger or stress hormones.
Skin & repairGHK-Cu is a natural copper-binding tripeptide (glycyl-histidyl-lysine plus copper) the body uses in tissue repair, and levels fall with age. In plain terms: applied to skin it signals collagen and healing, which is why it is a popular anti-aging skincare ingredient.
Commonly confused peptides
Long-form breakdowns of the pairs people confuse most, traced to primary sources.
One is approved in 35 countries and its largest trial found nothing. The other has never been injected in a published study.
Read comparisonMetabolic and weight lossBoth were tested in the same trial, in the same people, over the same 68 weeks. Semaglutide won on weight, and the combination beat both while coming in below their sum.
Read comparisonMetabolic and weight lossRetatrutide's 28.3 percent is being set against tirzepatide's 22.5 percent. Different trials, different lengths, and one of the numbers comes from a press release.
Read comparisonSexual and hormonalBoth are sold for sex. One works on desire and is FDA approved, the other works on hormones and stops working within two weeks.
Read comparisonLongevityOne has an FDA approval and a failed Phase 3. The other has never been given to a person in a published study.
Read comparisonGrowth hormoneTwo GHRH analogs tested for the same condition. One completed two Phase 3 trials and got approved. The other's Phase 2 was halted in 2006 and never restarted.
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