Deep dive comparisons
Long-form breakdowns of the pairs people confuse most, traced to primary sources.
HGH vs Sermorelin
Distributing HGH for anti-aging is a federal felony carrying five years. Sermorelin lost to it commercially in 2008 and can still be legally compounded.
IGF-1 LR3 vs IGF-1 DES
Neither has a single published human trial, and sources give LR3's half-life as anywhere from 6 to 30 hours. There is an FDA approved IGF-1, and it is neither of these.
Thymosin Alpha-1 vs LL-37
One is approved in 35 countries and its largest trial found nothing. The other has never been injected in a published study.
Cagrilintide vs Semaglutide
Both were tested in the same trial, in the same people, over the same 68 weeks. Semaglutide won on weight, and the combination beat both while coming in below their sum.
Semaglutide vs Tirzepatide
Tirzepatide won the head-to-head at 20.2 percent against 13.7. The 47 percent figure everyone quotes is relative; the absolute gap is 6.5 points, from an open-label trial.
Retatrutide vs Tirzepatide
Retatrutide's 28.3 percent is being set against tirzepatide's 22.5 percent. Different trials, different lengths, and one of the numbers comes from a press release.
PT-141 vs Kisspeptin
Both are sold for sex. One works on desire and is FDA approved, the other works on hormones and stops working within two weeks.
MOTS-c vs SS-31
One has an FDA approval and a failed Phase 3. The other has never been given to a person in a published study.
Tesamorelin vs CJC-1295
Two GHRH analogs tested for the same condition. One completed two Phase 3 trials and got approved. The other's Phase 2 was halted in 2006 and never restarted.
Melanotan I vs Melanotan II
Not two versions of one compound. One is an FDA approved implant for a rare disease, the other is approved nowhere and warned against by four regulators.
Epitalon vs MOTS-c
Two longevity peptides with no published human trial between them. Epitalon's famous human data belongs to a bovine extract, and MOTS-c is something your body already makes.
Glutathione vs NAD+
Both are sold as injections. NAD+ cannot enter cells intact, and a six month trial found oral glutathione raising body stores the injection is meant to fix.
Semax vs Selank
Same Russian lab, same seven amino acids, built for different problems: Semax for alertness, Selank for anxiety.
GHK-Cu vs Matrixyl
Two topical skin peptides with very different evidence: one carries copper, one carries a fat tail, and the most sold version of Matrixyl is built on the same tripeptide as GHK-Cu.
BPC-157 vs TB-500
Both are sold for tendon and muscle repair. BPC-157's human trials were enemas for ulcerative colitis, and TB-500's trials did not even use TB-500.
CJC-1295 with DAC vs without DAC
One name, two drugs: one has a measured half-life and three published human trials, the other has never been tested in a person.
Ipamorelin vs CJC-1295
They act on different receptors and are usually sold in the same vial. Each has human trials; the combination everyone buys has none.
MK-677 vs Ipamorelin
Same receptor, a pill against an injection. MK-677 has far more human data, and that is exactly why we know more about what is wrong with it.
KLOW vs GLOW
These are not two products. One contains the other: KLOW is GLOW plus KPV, and neither blend has ever been tested as a blend.
Sermorelin vs Ipamorelin
Two growth hormone peptides sold side by side. One was an approved drug and can still be compounded on prescription. The other was voted down in October 2024.
GLP-1 agonists compared
Twenty compounds act on the GLP-1 receptor. Eight are FDA approved. Most trial doses are not the same thing as a label dose. Here is what separates them.
21 published
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