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DSIP (Delta Sleep-Inducing Peptide)_Dosage, benefits & legal status

Also known as delta sleep-inducing peptide, emideltide, DSIP

Published July 22, 2026 · Updated August 14, 2026

A before-bed peptide used to deepen sleep.

SleepSleep peptideResearch only
InBrain, mood and sleep
Common vial size5 mg
Dose0.1 up to 0.2 mg per dose (start low, increase slowly)
FrequencyNightly
RouteUnder the skin (subcutaneous)
StatusResearch only
MixYour choice, calculate it
CycledNo established schedule

Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.

01

What is DSIP (Delta Sleep-Inducing Peptide)?

Plain language first. The technical label stays, but it never stands alone.

Overview

Taken before bed, it is used to encourage the deep, slow-wave stage of sleep, though results are inconsistent.

The technical version

DSIP (delta sleep-inducing peptide) is a natural 9-amino-acid brain peptide linked to deep sleep.

What it's used for

A before-bed peptide used to deepen sleep and improve sleep quality without the grogginess of sleeping pills.

02

How does DSIP (Delta Sleep-Inducing Peptide) work?

What it does in the body, and where.

DSIP was isolated in the 1970s from the blood of sleeping rabbits, and half a century later nobody is certain what it does.

  1. 01
    It appears to influence sleep-regulating signals
    The original finding was that it induced slow-wave sleep when infused into rabbits.
  2. 02
    Results in humans have been inconsistent
    Some small studies found effects on sleep onset, others found nothing. It has never been reliably reproduced.
  3. 03
    Its natural function is still unclear
    It is one of the longest-known peptides here and among the least understood.
Where it acts
Brain

Where this compound is thought to act.

03

What else is it used for?

Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.

  • Deeper sleepEarly research
  • Chronic pain and withdrawal symptoms, where the older studies were doneEarly research

The published record

Research index

481

Records indexed for DSIP (Delta Sleep-Inducing Peptide)400 papers and 0 trials indexed in detail.

94 in humans, 78 of them original studies.

FDA: Nominated but withdrawn; previously category 2.

Browse the records

In animalsPro
In the labPro
ReviewsPro
Senior author sharePro

Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 12 September 2026.

DSIP (Delta Sleep-Inducing Peptide) vial rendering
Compound field notes

At a glance

Four things to know about DSIP (Delta Sleep-Inducing Peptide)

01

Evidence

Research only

02

Category

Brain, mood and sleep

03

Common vial

5 mg

04

Half-life

About 15 minutes

04

How much, and do you cycle it?

The range, and whether you take breaks.

0.1 up to 0.2 mg per dose (start low, increase slowly), nightly. No established scheduleNo range

No published study has established how long to take this or whether a break is needed. Schedules quoted online come from vendors and forums, and different sources disagree.

Compare this against the whole library →

05

How long does it stay in the body?

The half-life, and where the figure comes from.

About 15 minutesHuman study

An enzymatic breakdown figure from mammalian and human work rather than a modern clinical study.

Source: Graf MV, Kastin AJ. Neurosci Biobehav Rev 1984, PMID 6514861. Also PMID 6548966

You can compare this against the whole library to see where it sits.

06

How do I dose and price it?

Enter your vial and your dose. Pick a mix. We show the draw and the cost.

The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.

Your vial size (mg)
Printed on the vial.
What you paid per vial
$
Used for cost per dose only.
Your dose (mcg)
Commonly referenced range: 0.1 up to 0.2 mg per dose (start low, increase slowly)Community practice

Choose your mix

your own mL
units · —
Enter your own volume

Measuring the water1 mL = one full 100-unit syringe.

Your draw

4 / 100 units
4 units is a very small line to read, so a small slip is a large error. A larger water volume above spreads the same dose across more units.
Full calculator with reorder date →Read a syringe →
What it costs

DSIP (Delta Sleep-Inducing Peptide) starts at $17.00 across 49 vendors, typically $3.60 – $11.19 per mg.

75 listings, last read Sep 6, 2026. Shipping and card fees are not included.

See all 75 listings →
07

How do you store it?

Before mixing, and after.

Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.

Unmixed lyophilized DSIP (Delta Sleep-Inducing Peptide) keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.

08

What are the side effects and cautions?

Known cautions and warnings for this compound.

Who should avoid it

Check these before anything else.
  • No modern controlled safety data exists
  • Pregnancy

Stop and get help

These are emergencies. Seek care.
  • Signs of an allergic reaction
  • Anything unusual, given the thin data

Common effects

Expected, and usually mild.
  • Reported as generally tolerated in small older studies
  • Results are inconsistent and there is no modern controlled safety database

What regulators say

Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.

09

Is DSIP (Delta Sleep-Inducing Peptide) approved?

And where the numbers on this page come from.

No. DSIP (Delta Sleep-Inducing Peptide) is not approved for any use, anywhere. It is sold labelled for laboratory research only, and there is no legal route to buy it for human use.

  • Approval status
    Research only
  • Route
    Under the skin (subcutaneous)
  • Checked
    August 2026

What has happened recently

The FDA calls this compound emideltide. On July 24, 2026, an FDA advisory committee voted 7 to 6 with one abstention against adding it to the list of substances pharmacies may compound. It was the only one of seven peptides reviewed that the committee turned down. Nothing changed for DSIP: no approved use in the US, no legal route through a compounding pharmacy, and no official quality standard.

You can compare this against the whole library, or read how to check a seller.

10

What else is like DSIP (Delta Sleep-Inducing Peptide)?

Others in Brain, mood and sleep, side by side.

If you're weighing DSIP (Delta Sleep-Inducing Peptide), it's worth reading Dihexa, Methylene Blue, and Pinealon in the same class.

YOU ARE HERE
DSIP (Delta Sleep-Inducing Peptide)

A before-bed peptide used to deepen sleep.

Research only
Dose
0.1 up to 0.2 mg per dose (start low, increase slowly)
How often
Nightly
DIHEXA
Dihexa

A very potent experimental peptide studied for memory and brain connections.

Research only
Dose
5 up to 20 mg per day (start low, increase slowly)
How often
Daily
MB
Methylene Blue

A low-dose blue compound taken for focus and energy.

OTC / supplement
Dose
5 up to 15 mg per day
How often
Daily
PINE
Pinealon

A short bioregulator taken in courses for brain and sleep, with thin evidence.

Research only
Dose
1 up to 10 mg per day (start low, increase slowly)
How often
10-20 day courses
See other brain, mood, and sleep peptides

Guides for this compound

Sources

  • FDA, Pharmacy Compounding Advisory Committee meeting, July 23-24, 2026(2026)
    FDA brought DSIP, which it calls emideltide, before its Pharmacy Compounding Advisory Committee on 24 July 2026, to consider adding it to the 503A bulks list. The uses evaluated were opioid withdrawal, chronic insomnia and narcolepsy. Two of those are serious clinical conditions with existing treatments, which is a higher bar than the general sleep-quality framing the compound is sold on. Two things about the page itself. It sets out the agenda and links FDA's briefing document for each substance, but it does not record how the vote went, so it tells you what was assessed rather than what was decided. And the page notes that advisory committees give non-binding recommendations which FDA generally follows but is not legally bound to, so even the vote would not be the final word.
  • FDA, bulk drug substances for compounding that may present significant safety risks(2026)
    FDA lists this compound as emideltide. It cites immunogenicity risk for certain routes and complexities with peptide-related impurities and characterisation, and states that it has not identified safety information for the proposed route of administration. As of the 22 April 2026 version of this page, the substance sits in the second table, headed bulk drug substances nominated but withdrawn, rather than in the live category 2 list. The nomination was withdrawn, which is not the same as being approved or cleared: FDA still publishes the safety language above, and no longer has a nomination in front of it to evaluate.

Last reviewed 14 August 2026

Beyond these, 400 records are indexed. Browse the records