DSIP (Delta Sleep-Inducing Peptide)_Dosage, benefits & legal status
Also known as delta sleep-inducing peptide, emideltide, DSIP
A before-bed peptide used to deepen sleep.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is DSIP (Delta Sleep-Inducing Peptide)?
Plain language first. The technical label stays, but it never stands alone.Overview
Taken before bed, it is used to encourage the deep, slow-wave stage of sleep, though results are inconsistent.
DSIP (delta sleep-inducing peptide) is a natural 9-amino-acid brain peptide linked to deep sleep.
What it's used for
A before-bed peptide used to deepen sleep and improve sleep quality without the grogginess of sleeping pills.
How does DSIP (Delta Sleep-Inducing Peptide) work?
What it does in the body, and where.DSIP was isolated in the 1970s from the blood of sleeping rabbits, and half a century later nobody is certain what it does.
- 01It appears to influence sleep-regulating signalsThe original finding was that it induced slow-wave sleep when infused into rabbits.
- 02Results in humans have been inconsistentSome small studies found effects on sleep onset, others found nothing. It has never been reliably reproduced.
- 03Its natural function is still unclearIt is one of the longest-known peptides here and among the least understood.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Deeper sleepEarly research
- Chronic pain and withdrawal symptoms, where the older studies were doneEarly research
Our sleep guide examines what the trials concluded, including the gap between intravenous studies and community use.
The published record
Papers and trials about DSIP (Delta Sleep-Inducing Peptide)
Searched: delta sleep-inducing peptide, delta-sleep-inducing peptide, DSIP.
Left out: DSIP (too short to disambiguate without context); DSIP (too short to disambiguate without context).
103 papers tagged human · 83 not reviews or lab · 18 clinical trial publications
Furthest stage reached: Published trials only, 18 clinical trial publications, no phased trial registered
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Nominated but withdrawn; previously category 2RegulatorsCounted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count. 426 papers and 0 trials indexed in detail.
At a glance
Four things to know about DSIP (Delta Sleep-Inducing Peptide)
How much, and do you cycle it?
The range, and whether you take breaks.0.1 up to 0.2 mg per dose (start low, increase slowly), nightly. No established schedule No range
No published study has established how long to take this or whether a break is needed. Schedules quoted online come from vendors and forums, and different sources disagree.
About 15 minutesHuman study
An enzymatic breakdown figure from mammalian and human work rather than a modern clinical study.
Source: Graf MV, Kastin AJ. Neurosci Biobehav Rev 1984, PMID 6514861. Also PMID 6548966
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
DSIP (Delta Sleep-Inducing Peptide) starts at $14.84 across 151 vendors, typically $3.67 – $11.00 per mg.
213 listings, last read Oct 24, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized DSIP (Delta Sleep-Inducing Peptide) keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Solubility, computed: 44% charged residues, 33% hydrophobic. Water usually sufficient.
A first-pass rule from peptide manufacturers' guidance. It does not account for disulfide bridges, salt form or how the powder was dried, and it predicts what should be easy rather than what will happen in your vial.
Who should avoid it
- No modern controlled safety data exists
- Pregnancy
Stop and get help
- Signs of an allergic reaction
- Anything unusual, given the thin data
Common effects
- Reported as generally tolerated in small older studies
- Results are inconsistent and there is no modern controlled safety database
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is DSIP (Delta Sleep-Inducing Peptide) approved?
And where the numbers on this page come from.No. DSIP (Delta Sleep-Inducing Peptide) is not approved for any use, anywhere. It is sold labeled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin (subcutaneous)
- Checked9 October 2026
- DoseFrom community reports. No regulator or trial established this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
What has happened recently
Not eligible for compounding under Section 503A: no monograph, not a component of an approved drug, not on the Bulks List. Previously in Category 2; the nomination was withdrawn. The FDA advisory committee voted against inclusion on July 24, 2026. The use the FDA evaluated: Opioid withdrawal, chronic insomnia and narcolepsy. Evaluation is not approval; if listed, the listed use would define what a pharmacy could compound it for.
What regulators say
From official documentsBriefing package prepared for the July 24, 2026 session
Listed as emideltide
Checked 22 September 2026FDA: FDA Briefing Document, Pharmacy Compounding Advisory Committee meeting of July 23 to 24, 2026: introduction and FDA proposalsConsidered at the July 24, 2026 session
Listed as emideltide
Checked 22 September 2026FDA: July 23 to 24, 2026 meeting of the Pharmacy Compounding Advisory Committee: meeting materialsNominated but withdrawn; previously category 2
Listed as Emideltide (DSIP)
Checked 11 September 2026FDA: Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks (category 2 and withdrawn nominations), current as of April 22, 2026
You can compare this against the whole library, or read how to check a seller.
What else is like DSIP (Delta Sleep-Inducing Peptide)?
Others in Brain, mood and sleep, side by side.If you're weighing DSIP (Delta Sleep-Inducing Peptide), it's worth reading Pinealon, Dihexa, and Semax + Selank blend in the same class.
A before-bed peptide used to deepen sleep.
- Dose
- 0.1 up to 0.2 mg per dose (start low, increase slowly)
- How often
- Nightly
A short bioregulator taken in courses for brain and sleep, with thin evidence.
- Dose
- 1 up to 10 mg per day (start low, increase slowly)
- How often
- 10-20 day courses
A very potent experimental peptide studied for memory and brain connections.
- Dose
- 5 up to 20 mg per day (start low, increase slowly)
- How often
- Daily
Two Russian research peptides in one vial, sold for focus and calm together.
- Dose
- Research only
- How often
- Daily, by convention
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
- FDA, Pharmacy Compounding Advisory Committee meeting, July 23-24, 2026(2026)FDA meeting page listing the bulk drug substances reviewed and the uses considered.
Beyond these, 426 records are indexed. Browse the records