Dihexa_
Also known as PNB-0408
A very potent experimental peptide studied for memory and brain connections.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Dihexa?
Plain language first. The technical label stays, but it never stands alone.Overview
Dihexa is a small peptide derived from angiotensin IV that powerfully activates HGF, a growth signal for brain connections. In plain terms: it is studied for building new synapses and reversing memory loss, with striking animal results but essentially no human safety data.
What it's used for
A very potent experimental compound studied for building new brain connections and reversing memory loss.
How does Dihexa work?
What it does in the body, and where.Dihexa is derived from angiotensin IV and is reported to be extraordinarily potent at forming new brain connections. The word extraordinary is the problem.
- 01It amplifies HGF signallingHepatocyte growth factor, which in the brain drives the formation of new synapses.
- 02Animal results were dramaticReported potency figures compare it to BDNF at many orders of magnitude lower concentration.
- 03It has never been tested in a humanNot once. A compound that powerfully promotes cell growth and connection in the brain, with no human safety data, warrants more caution than almost anything else here.
Where this compound is thought to act.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Memory and building new brain connectionsResearch only
- Neurodegenerative disease, based on animal work onlyResearch only
How much, and do you cycle it?
The range, and whether you take breaks.5 up to 20 mg per day (start low, increase slowly), daily. No established scheduleNo range
No published study has established how long to take this or whether a break is needed. Schedules quoted online come from vendors and forums, and different sources disagree.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
100 / 100 unitsHow do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Dihexa keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.22 July 2026No human trials exist. Its mechanism strongly stimulates a growth pathway, which raises a theoretical cancer concern nobody has tested.
Who should avoid it
- Any history of cancer, given the strong growth-signalling mechanism
- Pregnancy
- There are no human trials, so nobody can advise you properly
Stop and get help
- Any severe or unexpected symptom, given the absence of human safety data
Common effects
- Unknown in humans
- No reliable human safety profile exists
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Dihexa approved?
And where the numbers on this page come from.No. Not FDA-approved.
No human trials exist. Its mechanism strongly stimulates a growth pathway, which raises a theoretical cancer concern nobody has tested.
- DoseFrom research and community reports. No regulator has reviewed this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Reviewed22 July 2026
What else is like Dihexa?
Others in Brain, mood and sleep, side by side.If you're weighing Dihexa, it's worth reading Semax, Selank, and N-Acetyl Semax Amidate in the same class.
A very potent experimental peptide studied for memory and brain connections.
- Dose
- 5 up to 20 mg per day (start low, increase slowly)
- How often
- Daily
A nasal spray for sharper focus, memory, and mental clarity.
- Dose
- 0.2 up to 0.6 mg per day
- How often
- 1-2x daily
A nasal spray that eases anxiety while keeping you clear-headed.
- Dose
- 0.25 up to 0.5 mg per day
- How often
- 1-2x daily
A longer-lasting version of Semax for focus and memory.
- Dose
- 0.2 up to 0.4 mg per day
- How often
- 1-2x daily
10What these words mean
Show glossary +
What these words mean
- Titrate
- Starting at a low dose and increasing it slowly over time so your body adjusts and side effects stay mild.
- Subcutaneous
- An injection just under the skin, into the fat layer, usually with a short, thin insulin needle.
- Intramuscular (IM)
- An injection into a muscle, using a longer needle.
- Reconstitution
- Mixing a powdered peptide with liquid (bacteriostatic water) so it can be drawn into a syringe.
- Bacteriostatic water
- Sterile water with a tiny amount of preservative, used to mix powdered peptides.
- Concentration
- How strong the mixed peptide is, in milligrams per milliliter (mg/mL). More water makes it weaker; less water makes it stronger.
- Units (on the syringe)
- The marks on an insulin syringe. 100 units equals 1 mL. They measure how much liquid you draw, not the dose in milligrams.
- mcg and mg
- Units of dose. 1 milligram (mg) equals 1,000 micrograms (mcg).
- GLP-1
- A natural gut hormone that lowers appetite and blood sugar. Drugs that copy it, like semaglutide, are used for weight loss.
- Growth hormone secretagogue
- A compound that nudges your body to release more of its own growth hormone, rather than injecting the hormone itself.
- Half-life
- How long a compound stays active in your body. A longer half-life means you inject less often.
- Peptide vs small molecule
- A peptide is a short chain of amino acids. A few items here (like MK-677 or methylene blue) are small molecules, not true peptides, but people use them the same way.
- Research only
- No approved dose or use in people. Sold for research and not reviewed by the FDA for safety or quality.
- Investigational
- Still being tested in clinical trials and not yet approved or legally sold for general use.
- Banned in drug-tested sport
- Prohibited by the World Anti-Doping Agency (WADA); using it can disqualify a competing athlete.
Last reviewed 22 July 2026