Dihexa_Dosage, benefits & legal status
Also known as PNB-0408
A very potent experimental peptide studied for memory and brain connections.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Dihexa?
Plain language first. The technical label stays, but it never stands alone.Overview
It is studied for building new connections in the brain and reversing memory loss. Animal results were striking. There is essentially no human safety data.
Dihexa is a small peptide derived from angiotensin IV that powerfully activates HGF, a growth signal for brain connections.
What it's used for
A very potent experimental compound studied for building new brain connections and reversing memory loss.
How does Dihexa work?
What it does in the body, and where.Dihexa is derived from angiotensin IV and is reported to be extraordinarily potent at forming new brain connections. The word extraordinary is the problem.
- 01It amplifies HGF signalingHepatocyte growth factor, which in the brain drives the formation of new synapses.
- 02Animal results were dramaticReported potency figures compare it to BDNF at many orders of magnitude lower concentration.
- 03It has never been tested in a humanNot once. A compound that powerfully promotes cell growth and connection in the brain, with no human safety data, warrants more caution than almost anything else here.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Memory and building new brain connectionsResearch only
- Neurodegenerative disease, based on animal work onlyResearch only
The published record
Papers and trials about Dihexa
Searched: Dihexa, PNB-0408.
8 papers tagged human · 3 not reviews or lab · 0 clinical trial publications
Furthest stage reached: No clinical trial on record
Compare this against the whole library →
Nominated but withdrawn; previously category 2RegulatorsCounted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about Dihexa
Evidence
Category
Brain, mood and sleep
Common vial
10 mg
Half-life
Nothing published
How much, and do you cycle it?
The range, and whether you take breaks.5 up to 20 mg per day (start low, increase slowly), daily. No established schedule No range
No published study has established how long to take this or whether a break is needed. Schedules quoted online come from vendors and forums, and different sources disagree.
Nothing publishedNo figure
Nothing published in people or animals.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Dihexa starts at $22.54 across 55 vendors, typically $2.82 – $20.00 per mg.
78 listings, last read Oct 24, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Dihexa keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Any history of cancer, given the strong growth-signalling mechanism
- Pregnancy
- There are no human trials, so nobody can advise you properly
Stop and get help
- Any severe or unexpected symptom, given the absence of human safety data
Common effects
- Unknown in humans
- No reliable human safety profile exists
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Dihexa approved?
And where the numbers on this page come from.No. Dihexa is not approved for any use, anywhere. It is sold labeled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteBy mouth, under the skin, or on the skin
- Checked22 July 2026
- DoseFrom community reports. No regulator or trial established this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesNone traced yet.
What has happened recently
No human trials exist. Its mechanism strongly stimulates a growth pathway, which raises a theoretical cancer concern nobody has tested.
What regulators say
From official documentsNominated but withdrawn; previously category 2
FDA has not identified any human exposure data for any route
Checked 11 September 2026FDA: Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks (category 2 and withdrawn nominations), current as of April 22, 2026
You can compare this against the whole library, or read how to check a seller.
What else is like Dihexa?
Others in Brain, mood and sleep, side by side.If you're weighing Dihexa, it's worth reading Semax + Selank blend, Adamax, and PE-22-28 in the same class.
A very potent experimental peptide studied for memory and brain connections.
- Dose
- 5 up to 20 mg per day (start low, increase slowly)
- How often
- Daily
Two Russian research peptides in one vial, sold for focus and calm together.
- Dose
- Research only
- How often
- Daily, by convention
A product name that covers at least two different molecules.
- Dose
- Research only
- How often
- No established schedule
An experimental fast-acting antidepressant peptide.
- Dose
- Research only
- How often
- As studied
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence
Beyond these, 19 records are indexed. Browse the records