Dihexa_Dosage, benefits & legal status
Also known as PNB-0408
A very potent experimental peptide studied for memory and brain connections.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Dihexa?
Plain language first. The technical label stays, but it never stands alone.Overview
It is studied for building new connections in the brain and reversing memory loss. Animal results were striking. There is essentially no human safety data.
Dihexa is a small peptide derived from angiotensin IV that powerfully activates HGF, a growth signal for brain connections.
What it's used for
A very potent experimental compound studied for building new brain connections and reversing memory loss.
How does Dihexa work?
What it does in the body, and where.Dihexa is derived from angiotensin IV and is reported to be extraordinarily potent at forming new brain connections. The word extraordinary is the problem.
- 01It amplifies HGF signallingHepatocyte growth factor, which in the brain drives the formation of new synapses.
- 02Animal results were dramaticReported potency figures compare it to BDNF at many orders of magnitude lower concentration.
- 03It has never been tested in a humanNot once. A compound that powerfully promotes cell growth and connection in the brain, with no human safety data, warrants more caution than almost anything else here.
Where this compound is thought to act.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Memory and building new brain connectionsResearch only
- Neurodegenerative disease, based on animal work onlyResearch only
The published record
18
Records indexed for Dihexa
8 in humans, 3 of them original studies.
FDA: Nominated but withdrawn; previously category 2.
Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 12 September 2026.
At a glance
Four things to know about Dihexa
Evidence
Research only
Category
Brain, mood and sleep
Common vial
10 mg
Half-life
Nothing published
How much, and do you cycle it?
The range, and whether you take breaks.5 up to 20 mg per day (start low, increase slowly), daily. No established scheduleNo range
No published study has established how long to take this or whether a break is needed. Schedules quoted online come from vendors and forums, and different sources disagree.
How long does it stay in the body?
The half-life, and where the figure comes from.Nothing publishedNo figure
Nothing published in people or animals.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
100 / 100 unitsDihexa starts at $35.79 across 16 vendors, typically $7.16 – $22.50 per mg.
22 listings, last read Sep 6, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Dihexa keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Any history of cancer, given the strong growth-signalling mechanism
- Pregnancy
- There are no human trials, so nobody can advise you properly
Stop and get help
- Any severe or unexpected symptom, given the absence of human safety data
Common effects
- Unknown in humans
- No reliable human safety profile exists
What regulators say
- FDA: Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks (category 2 and withdrawn nominations), current as of April 22, 2026Nominated but withdrawn; previously category 2
FDA has not identified any human exposure data for any route
Checked 11 September 2026
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Dihexa approved?
And where the numbers on this page come from.No. Dihexa is not approved for any use, anywhere. It is sold labelled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteBy mouth, under the skin, or on the skin
- CheckedSeptember 2026
What has happened recently
No human trials exist. Its mechanism strongly stimulates a growth pathway, which raises a theoretical cancer concern nobody has tested.
You can compare this against the whole library, or read how to check a seller.
- DoseFrom research and community reports. No regulator has reviewed this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesCognitive Vitality report on dihexa, Alzheimer's Drug Discovery FoundationFacilitation of hippocampal synaptogenesis and spatial memory by C-terminal truncated Nle1-angiotensin IV analogs, Journal of Pharmacology and Experimental TherapeuticsFDA, bulk drug substances for compounding that may present significant safety risks
- Reviewed8 September 2026
What else is like Dihexa?
Others in Brain, mood and sleep, side by side.If you're weighing Dihexa, it's worth reading Methylene Blue, Pinealon, and P21 in the same class.
A very potent experimental peptide studied for memory and brain connections.
- Dose
- 5 up to 20 mg per day (start low, increase slowly)
- How often
- Daily
A low-dose blue compound taken for focus and energy.
- Dose
- 5 up to 15 mg per day
- How often
- Daily
A short bioregulator taken in courses for brain and sleep, with thin evidence.
- Dose
- 1 up to 10 mg per day (start low, increase slowly)
- How often
- 10-20 day courses
An experimental peptide studied for new brain cells and memory.
- Dose
- Research only
- How often
- As studied
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
- Cognitive Vitality report on dihexa, Alzheimer's Drug Discovery Foundation(2021)Independent assessment. Dihexa improved cognition in rats with induced or age-related impairment but did not improve cognition in rats with normal cognition. No human studies, no clinical trials, no observational studies, and no long-term safety work in animals or humans. The report notes that activating HGF and c-Met could in theory promote tumour growth.
- Facilitation of hippocampal synaptogenesis and spatial memory by C-terminal truncated Nle1-angiotensin IV analogs, Journal of Pharmacology and Experimental Therapeutics(2011)The foundational rodent work behind the dihexa scaffold, from the Harding lab at Washington State University. Rats and cultured neurons.
- FDA, bulk drug substances for compounding that may present significant safety risks(2026)FDA states that it has not identified any human exposure data on drug products containing dihexa acetate administered by any route, and that it lacks important information about any safety issues the substance raises, including whether it would cause harm in people. That is an official record of an absence rather than a safety finding. As of the 22 April 2026 version of this page, the substance sits in the second table, headed bulk drug substances nominated but withdrawn, rather than in the live category 2 list. The nomination was withdrawn, which is not the same as being approved or cleared: FDA still publishes the safety language above, and no longer has a nomination in front of it to evaluate.
Last reviewed 8 September 2026
Beyond these, 18 records are indexed. Browse the records