PE-22-28_Dosage, benefits & legal status
An experimental fast-acting antidepressant peptide.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is PE-22-28?
Plain language first. The technical label stays, but it never stands alone.Overview
It is studied as a fast-acting antidepressant that may also help the brain adapt. There is no human data.
PE-22-28 is a peptide based on spadin that blocks a potassium channel (TREK-1) tied to mood.
What it's used for
An experimental peptide studied as a fast-acting antidepressant that may also support brain flexibility.
How does PE-22-28 work?
What it does in the body, and where.PE-22-28 is derived from spadin and blocks a potassium channel involved in mood regulation.
- 01It blocks TREK-1A channel that, when knocked out in mice, produces an antidepressant-resistant phenotype. Blocking it pharmacologically mimics that.
- 02The antidepressant effect appeared within days in animalsRather than the weeks conventional antidepressants take, which is what makes the target interesting.
- 03No human trials existThe target is legitimate and under active research. This specific compound has not been tested in people.
A schematic of the compound's mechanism, not a diagnostic image.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Fast-acting relief from depressionResearch only
The published record
Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 12 September 2026.
At a glance
Four things to know about PE-22-28
Evidence
Research only
Category
Brain, mood and sleep
Common vial
5 mg
Half-life
Nothing published
How much, and do you cycle it?
The range, and whether you take breaks.Research only, as studied. No established scheduleNo range
No published study has established how long to take this or whether a break is needed. Schedules quoted online come from vendors and forums, and different sources disagree.
How long does it stay in the body?
The half-life, and where the figure comes from.Nothing publishedNo figure
Nothing published for PE-22-28 itself. The peptide it derives from, spadin, clears in about 7 minutes in rodents, which is a different molecule in a different species.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
0 / 100 unitsPE-22-28 starts at $21.00 across 14 vendors, typically $4.90 – $7.20 per mg.
15 listings, last read Sep 5, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized PE-22-28 keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Pregnancy or breastfeeding
- Any prescription medicine you take regularly, without checking for interactions first
- Anyone who wants established safety data, because none exists for this compound in humans
Stop and get help
- Spreading hives, swelling of the face or throat, or trouble breathing, which can happen with any injection and is a medical emergency
- Redness, heat, or pus at the injection site, which can signal infection
- Any severe or unexpected symptom
- Anything unusual, since there is no known safety profile to compare it against
Common effects
- There is no human data.
- Redness, soreness, or a small bump at the injection site
- Beyond the above, unknown. There is no reliable human data on what this compound commonly causes
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is PE-22-28 approved?
And where the numbers on this page come from.No. PE-22-28 is not approved for any use, anywhere. It is sold labelled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin (subcutaneous)
- CheckedJuly 2026
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
You can compare this against the whole library, or read how to check a seller.
- DoseFrom research and community reports. No regulator has reviewed this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
- Reviewed22 July 2026
What else is like PE-22-28?
Others in Brain, mood and sleep, side by side.If you're weighing PE-22-28, it's worth reading N-Acetyl Selank Amidate, Noopept (Omberacetam), and Cortexin in the same class.
An experimental fast-acting antidepressant peptide.
- Dose
- Research only
- How often
- As studied
A longer-lasting version of Selank, with no study of its own.
- Dose
- Research only
- How often
- 1-2x daily
A Russian memory drug sold as a supplement in the US, where selling it is unlawful.
- Dose
- 10 up to 30 mg per day (start low, increase slowly)
- How often
- 1-2x daily
A brain extract from cattle, injected into muscle, used widely in Russia.
- Dose
- 10 mg per day
- How often
- Daily, in 10-day courses
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
- Shortened spadin analogs display better TREK-1 inhibition, in vivo stability and antidepressant activity, Frontiers in Pharmacology(2017)The paper that created PE 22-28, and the origin of every number quoted for it. The compound was designed by taking spadin, letting mouse serum degrade it, and picking the shortest fragment that still blocked the TREK-1 potassium channel. It blocks that channel about 300 times more tightly than spadin does, with an IC50 of 0.12 nM against 40 to 60 nM, and it left four related channels and the cardiac hERG channel alone. The antidepressant evidence is entirely mouse behaviour: forced swim, novelty-suppressed feeding and learned helplessness, ten mice per group, at 3 micrograms per kilogram injected into the abdomen. Read the duration claim carefully. The widely quoted figure of about 23 hours was measured only on two chemically modified versions, G/A-PE 22-28 and its biotinylated form; PE 22-28 itself was not in that experiment, and the serum stability method describes spadin rather than PE 22-28. No human study of this peptide exists.
Last reviewed 22 July 2026
Beyond these, 1 records are indexed. Browse the records