Epitalon_Dosage, benefits & legal status
Also known as epithalon, epithalamin, AEDG
A longevity peptide taken in short courses for sleep and anti-aging.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Epitalon?
Plain language first. The technical label stays, but it never stands alone.Overview
It is taken in short courses for sleep and anti-aging. The idea is that it supports the body's internal clock. Strong human evidence is thin.
Epitalon is a 4-amino-acid 'bioregulator' from the Russian Khavinson family, based on a natural pineal-gland peptide.
What it's used for
A longevity peptide taken in short courses for deeper sleep and anti-aging, thought to support the body's internal aging clock.
How does Epitalon work?
What it does in the body, and where.Epitalon is four amino acids long, from the Russian bioregulator tradition, based on a peptide from the pineal gland. The claims made for it are large and the evidence behind them is unusually narrow.
- 01The proposal is that it activates telomeraseTelomerase rebuilds the protective caps on the ends of your chromosomes, which shorten each time a cell divides.
- 02In cell studies, cells divided past their usual limitThat is the finding the anti-aging claims rest on.
- 03The evidence traces to a single laboratoryThe telomerase and lifespan figures come from one Russian research group and have not been independently reproduced or published anywhere linkable. Treat them with more caution than anything else on this site.
A schematic of the compound's mechanism, not a diagnostic image.
What else is it used for?
Each group carries its own evidence level.Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
Telomeres and cell aging
Research only- Lab studyIn human cell cultures it raised telomerase activity about 2.4-fold and lengthened telomeres, letting cells divide past their normal limit.
- Lab studyA 2025 independent study at a UK university confirmed telomere lengthening across several human cell lines.
These figures trace to a single Russian laboratory and have not been independently published in a source we can link to. Treat them with more caution than the numbers elsewhere on this site.
Lifespan in animals
Research only- Animal studyFemale mice lived about 12.3% longer on average and had less lymphoma.
- Animal studyIn aged monkeys and elderly people, a related pineal peptide restored the night-time melatonin rhythm.
- No dataAlmost all of this comes from a single Russian laboratory, and turning on telomerase carries a theoretical cancer concern.
These figures trace to a single Russian laboratory and have not been independently published in a source we can link to. Treat them with more caution than the numbers elsewhere on this site.
The published record
170
Records indexed for Epitalon
56 in humans, 33 of them original studies.
FDA: Nominated but withdrawn; previously category 2.
Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 12 September 2026.
At a glance
Four things to know about Epitalon
Evidence
Research only
Category
Longevity and energy
Common vial
10 mg
Half-life
Nothing published
How much, and do you cycle it?
The range, and whether you take breaks.5 up to 10 mg per day (start low, increase slowly), 10-20 day courses. Courses of 10 to 20 days, repeated two or three times a yearCommunity practice
The course structure is how the Khavinson protocols specify it and how it is sold. No trial has compared course dosing against continuous use, or established what the gap between courses should be.
How long does it stay in the body?
The half-life, and where the figure comes from.Nothing publishedNo figure
Nothing published. A 2025 review notes that even basic physical characterisation of the peptide is limited, let alone how fast it clears.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
100 / 100 unitsEpitalon starts at $23.16 across 57 vendors, typically $1.70 – $7.70 per mg.
102 listings, last read Sep 6, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Epitalon keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- No formal contraindications established
- Pregnancy
Stop and get help
- Signs of an allergic reaction
- Anything unusual, given the thin data
Common effects
- No notable adverse events were reported in the available studies
- Those studies are small, mostly Russian, largely not blinded, and not independently replicated, so safety is not robustly established
What regulators say
- FDA: Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks (category 2 and withdrawn nominations), current as of April 22, 2026Nominated but withdrawn; previously category 2Checked 11 September 2026
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Epitalon approved?
And where the numbers on this page come from.No. Epitalon is not approved for any use, anywhere. It is sold labelled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin or into muscle
- CheckedAugust 2026
What has happened recently
On July 24, 2026, an FDA advisory committee voted by a narrow margin to recommend adding Epitalon to the list of substances pharmacies may compound. The FDA's own scientific reviewers had advised against it. The vote is advice, not a decision. HHS has to accept it and write formal rules first, so compounding Epitalon is still not legal today.
You can compare this against the whole library, or read how to check a seller.
- DoseFrom research and community reports. No regulator has reviewed this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
- Reviewed14 August 2026
What else is like Epitalon?
Others in Longevity and energy, side by side.If you're weighing Epitalon, it's worth reading NAD+, SS-31 (Elamipretide), and FOXO4-DRI in the same class.
A longevity peptide taken in short courses for sleep and anti-aging.
- Dose
- 5 up to 10 mg per day (start low, increase slowly)
- How often
- 10-20 day courses
A cellular fuel taken for energy, focus, and anti-aging.
- Dose
- 50 up to 100 mg per dose (start low, increase slowly)
- How often
- 2-3x/week
A mitochondrial peptide, approved in 2025 for the rare genetic disease Barth syndrome.
- Dose
- 40 mg per day
- How often
- Daily
An experimental senolytic that clears aging cells, with no human safety data.
- Dose
- Research only
- How often
- Cycled
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
- FDA, Pharmacy Compounding Advisory Committee meeting, July 23-24, 2026(2026)FDA brought Epitalon before its Pharmacy Compounding Advisory Committee on 24 July 2026, to consider adding it to the 503A bulks list. The use evaluated was insomnia. That is the single most informative detail on this page for anyone considering this compound: not longevity, not telomeres, not ageing. Whoever nominated it put forward sleep. Two things about the page itself. It sets out the agenda and links FDA's briefing document for each substance, but it does not record how the vote went, so it tells you what was assessed rather than what was decided. And the page notes that advisory committees give non-binding recommendations which FDA generally follows but is not legally bound to, so even the vote would not be the final word.
- FDA, bulk drug substances for compounding that may present significant safety risks(2026)FDA cites immunogenicity risk for certain routes from aggregation and peptide-related impurities, and states that it has not identified safety information for the proposed route, so it lacks sufficient information to know whether the drug would cause harm in people. As of the 22 April 2026 version of this page, the substance sits in the second table, headed bulk drug substances nominated but withdrawn, rather than in the live category 2 list. The nomination was withdrawn, which is not the same as being approved or cleared: FDA still publishes the safety language above, and no longer has a nomination in front of it to evaluate.
Last reviewed 14 August 2026
Beyond these, 170 records are indexed. Browse the records