Peptides for longevity and energy
Compounds taken for aging, mitochondria, and energy.
No compound on this page has been shown to make a person live longer. What they have is a target in aging biology, such as mitochondrial function, telomeres, senescent cells or the growth hormone axis, along with results in cells, worms, mice, or short human studies that measured a marker rather than a life.
The mitochondrial compounds are the most substantial. SS-31 has been through real clinical trials, and MOTS-c has early human work, both in specific disease settings rather than healthy aging. Epitalon and the bioregulator family sit at the other end: decades of Russian publications and no pharmacokinetics at all.
NAD+ is here despite not being a peptide, because it is bought for the same reasons through the same vendors, and leaving it out would make the page less useful than it should be.
A coenzyme every cell uses to make energy, with levels that fall with age. Evidence for injecting it is still early.
A short peptide your own mitochondria make. Signals cells to burn more fuel, explored for metabolism and aging.
A 4-amino-acid Khavinson peptide taken in short courses for sleep and aging. Human evidence is thin.
Stabilizes the inner wall of mitochondria so damaged ones make energy again. Approved in 2025 for Barth syndrome.
Designed to make worn-out 'zombie' cells self-destruct. Striking in animals, almost no human safety data.
The pharmacy-aisle vitamin for nerves and red blood cells, sold by peptide vendors in a research vial.
A 4-amino-acid Khavinson peptide sold for heart muscle and blood vessels, with very little human research.
Designed to stick to a protein on cancer cells and punch holes in them. It has never been tested in a person.
A 3-amino-acid Khavinson peptide sold for blood-vessel health with age, with very little human research.
A 4-amino-acid Khavinson peptide sold for lung and airway health, with very little human research.
NAD+ 100 mg, MOTS-c 10 mg and 5-Amino-1MQ 10 mg in one vial. Two of the three are not peptides.
Epitalon with its ends capped so enzymes take longer to break it down.
Raw material the body uses to make NAD+, one step closer to it than nicotinamide riboside.
A protein the body makes less of with age. Mice given more of it live longer.
A bile acid that helps bile flow and takes strain off liver cells. Taken alongside things that are hard on the liver.
The brain's wakefulness peptide, missing in people with narcolepsy. Studied as a nasal spray on limited data.
From the same p53 program as PNC-27. It worked in dishes and mice, and no published study has given it to a person.
Alagebrium, meant to break the sugar-protein crosslinks that stiffen tissue with age.
The only peptide in the MOTS-c family with finished human results. It completed phase 1, moved liver fat no better than placebo, and the company then said its formulation could not be developed further.
A myostatin relative once reported to rejuvenate old tissue. Follow-up studies have been arguing about it ever since.
A form of vitamin B3 the body turns into NAD+, one step further back than NMN. It is sold mostly as Niagen.
A seven-residue Drp1 fragment that blocks stress-driven mitochondrial splitting in mice. Never given to a person.
One of six small humanin-like peptides. Its research on insulin sensitivity and mitochondria is all in cells and mice.
Sold beside SHLP2 as if the two did the same thing. The published work points in a different direction.
Made by gut bacteria from pomegranates, walnuts and berries. Tells cells to clear out worn-out mitochondria.
One has an FDA approval and a failed Phase 3. The other has never been given to a person in a published study.
Two longevity peptides with no published human trial between them. Epitalon's famous human data belongs to a bovine extract, and MOTS-c is something your body already makes.
Three points on one pathway: compare cellular uptake, human evidence and changing supplement rules.
Common questions
Can any peptide extend human lifespan?
Nothing on this page has been shown to extend human lifespan. Claims come from cell work, animal models and short human studies measuring surrogate markers rather than survival.
What do mitochondrial peptides do?
Compounds like MOTS-c and SS-31 act on mitochondrial function and oxidative stress. Early human data exists for some, mostly in specific disease populations rather than healthy aging.
Is NAD+ a peptide?
No. NAD+ is a coenzyme, not a peptide, but it is grouped here because it is used for the same energy and aging goals and sold through the same channels.