PNC-28_Dosage, benefits & legal status
Also known as PNC28, PNC-28 peptide, p53 anticancer peptide
The lesser-known sibling of PNC-27, with the same cancer claims and the same missing human trials.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is PNC-28?
Plain language first. The technical label stays, but it never stands alone.Overview
It worked in dishes and in mice, and it has never been given to a person in any published study.
PNC-28 is a p53-derived peptide designed to bind membrane-bound HDM-2 on tumor cells and lyse them, studied only in vitro and in animals.
What it's used for
Sold online with anti-cancer claims. It has only ever been studied in cells and animals.
How does PNC-28 work?
What it does in the body, and where.A designed peptide from the p53 program, built to find a marker on cancer cells and break them open.
- 01It looks for HDM-2Many cancer cells display the HDM-2 protein on their outer surface, while healthy cells mostly keep it inside.
- 02It disrupts the membraneIn cell studies, binding is followed by the membrane failing and the cell bursting.
- 03It has never been tested in a personAll of the evidence is in dishes and animals. Nothing is known about where it goes, what it hits, or what it does in a human body.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Killing cancer cells in a dish, which it does under lab conditionsEarly research
- Treating cancer in people, the claim it is sold on, which has never been testedResearch only
The published record
Papers and trials about PNC-28
Searched: PNC-28, PNC28.
5 papers tagged human · 4 not reviews or lab · 0 clinical trial publications
Furthest stage reached: No clinical trial on record
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about PNC-28
How much, and do you cycle it?
The range, and whether you take breaks.Research only, varies. No established pattern research-only
There is no human use to describe. Any schedule printed by a vendor has no evidence behind it.
Not establishedNo figure
No pharmacokinetic work has been published for this compound. Nothing is known about how long it persists in a body.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
PNC-28 starts at $159.99 across 2 vendors.
2 listings, last read Oct 24, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized PNC-28 keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.If you or someone you care about has cancer, talk to an oncologist before considering anything you read about this peptide. Delaying or replacing treatment that works is the real risk here, and it is a much bigger risk than anything in the vial. There is no established dose because no dose has ever been tested in a person.
Solubility, computed: 44% charged residues, 41% hydrophobic. Water usually sufficient.
A first-pass rule from peptide manufacturers' guidance. It does not account for disulfide bridges, salt form or how the powder was dried, and it predicts what should be easy rather than what will happen in your vial.
Who should avoid it
- Anyone with cancer who is using it in place of, or alongside, real treatment without telling their oncologist
- Pregnancy
- Anyone expecting it to do what the marketing says, since no human evidence exists
Stop and get help
- Any reaction at all, since there is no safety record to compare against
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Unknown. No human study has recorded what happens to a person taking this.
- In cell studies it kills cells by disrupting their membranes, which is a messy form of cell death. What that means in a body is untested.
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is PNC-28 approved?
And where the numbers on this page come from.No. PNC-28 is not approved for any use, anywhere. It is sold labeled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin (subcutaneous)
- Checked12 September 2026
- DoseFrom community reports. No regulator or trial established this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
What has happened recently
Not approved anywhere and never tested in a human trial. Vendor pages sometimes present the published cell and mouse work as if it were evidence of benefit in people. It is not, and the research program behind this family of peptides has produced no registered human trial in over two decades.
You can compare this against the whole library, or read how to check a seller.
What else is like PNC-28?
Others in Longevity and energy, side by side.If you're weighing PNC-28, it's worth reading ALT-711, CB4211, and GDF-11 in the same class.
The lesser-known sibling of PNC-27, with the same cancer claims and the same missing human trials.
- Dose
- Research only
- How often
- Varies
An anti-ageing molecule from the 1990s that broke sugar-protein crosslinks in rats and disappointed in people.
- Dose
- Research only
- How often
- No established pattern
A modified MOTS-c analog that completed human safety trials and was abandoned over its formulation.
- Dose
- 25 mg per day in the phase 1b stage
- How often
- Once daily
The young blood rejuvenation protein, and the field that spent a decade arguing about it.
- Dose
- Research only
- How often
- Not established
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- Why Does My Peptide Injection Itch or Welt
Injection-site irritation, a histamine reaction, or a true allergy, and how to tell them apart.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
Sources
- Europe PMC literature search for PNC-28(2026)The published record for this compound consists of cell and animal work from the same research program as PNC-27. No human trial appears in the literature index.
Beyond these, 7 records are indexed. Browse the records