NMN_Dosage, benefits & legal status
Also known as nicotinamide mononucleotide, beta-nicotinamide mononucleotide, b-NMN, MIB-626
The NAD+ precursor the FDA banned, then un-banned on a technicality.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
5 of 6 listings we track are vials, the form used for injection.
What is NMN?
Plain language first. The technical label stays, but it never stands alone.Overview
It is raw material the body uses to make NAD+, which every cell needs for energy and repair.
NMN is nicotinamide mononucleotide, a direct precursor in the NAD+ salvage pathway, one step closer to NAD+ than nicotinamide riboside.
What it's used for
An oral NAD+ precursor taken for energy and aging. Its legal status has changed twice in four years.
How does NMN work?
What it does in the body, and where.NAD+ falls with age. Every compound in this family is an attempt to put it back.
- 01NAD+ itself is too large to enter cells easilyThat is why precursors exist, and why injecting NAD+ directly is a different proposition from taking a precursor by mouth.
- 02NMN sits one step from NAD+It is closer in the pathway than nicotinamide riboside is.
- 03There is a long-running argument about how it gets inOne reading is that NMN must be converted to NR before crossing the cell membrane, which would remove its supposed advantage. This is contested and the companies on each side sell the competing molecule.
- 04Blood NAD+ does riseThat part is consistent across trials. Whether raised blood NAD+ translates into anything a person feels or measures is where the evidence thins out.
A schematic of the compound's mechanism, not a diagnostic image.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Raising blood NAD+ levelsInvestigational
- Muscle insulin sensitivity in prediabetic womenEarly research
- General longevity and healthspanEarly research
The published record
Papers and trials about NMN
212 papers tagged human · 114 not reviews or lab · 17 clinical trial publications
37 registered trials · 2 with posted results
Furthest stage reached: Phase 4 as registered, status not updated
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count. 499 papers and 37 trials indexed in detail.
At a glance
Four things to know about NMN
Evidence
Supplement
Category
Longevity and energy
Common vial
Varies
Half-life
Very short, minutes rather than hours
How much, and do you cycle it?
The range, and whether you take breaks.250 up to 1,000 mg per day, daily. Continuous in the trials Trial dose
Published oral trials dose daily for weeks to months without a planned break. Nothing has tested cycling.
Very short, minutes rather than hoursNo figure
NMN is cleared from plasma rapidly and converted onward, so the plasma figure says little about the NAD+ effect, which builds over days of repeated dosing. We have not verified a specific figure against a primary pharmacokinetic paper.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
NMN starts at $90.00 across 4 vendors, typically $0.25 – $0.60 per mg.
6 listings, last read Oct 11, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized NMN keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Pregnancy and breastfeeding, on absent data
- Active cancer, since NAD+ availability affects tumor metabolism and the direction is not settled
- Children, who have not been studied
Stop and get help
- Persistent flushing with dizziness or a pounding heartbeat
- Any new or unexplained symptom that starts after beginning it
- Spreading redness at an injection site, if injecting
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Generally well tolerated in short oral trials
- Nausea at higher doses
- Flushing
- Headache
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is NMN approved?
And where the numbers on this page come from.Not as a medicine. NMN is sold without a prescription as a supplement, which is a different thing from being approved as a drug.
- Injected under the skin and Injected into muscleResearch onlyNot FDA approved by this routeInjectable NMN is not approved for anything, has minimal controlled human data, and is not the form any of the published oral trials used.
- By mouthSupplementSold as a supplementLegal to sell as a dietary supplement again since the FDA reversed its exclusion in 2025.
- RouteBy mouth, or under the skin
- Checked24 August 2026
- DoseFrom published clinical trials. Not approved by a regulator for this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
What has happened recently
The status flipped twice and the second flip turned on the reading of a single word. In November 2022 the FDA told NDI notifiers that NMN was excluded from the definition of a dietary supplement, because it had been authorised for investigation as a new drug, MIB-626, before being lawfully marketed as a supplement. In its response to citizen petition FDA-2023-P-0872 the agency reversed that. It did not change its view of the facts. It changed its reading of the race-to-market clause, deciding that the earlier supplement marketing does not have to have been lawful to count. Since NMN was on sale in the US as a supplement as early as 2017, before the drug authorisation, it wins that race and is no longer excluded. The FDA also conceded in the same letter that its original searches missed the connection because staff reviewing the notification did not realise MIB-626 referred to NMN.
You can compare this against the whole library, or read how to check a seller.
What else is like NMN?
Others in Longevity and energy, side by side.If you're weighing NMN, it's worth reading MitoPrime blend (NAD+ / MOTS-c / 5-Amino-1MQ), Klotho, and ALT-711 in the same class.
The NAD+ precursor the FDA banned, then un-banned on a technicality.
- Dose
- 250 up to 1,000 mg per day
- How often
- Daily
Three cellular-energy compounds in one 120 mg vial, only one of which is a peptide.
- Dose
- 1 up to 5 mg MOTS-c per day (the rest follows the fixed 10:1:1 ratio)
- How often
- Daily
A real longevity protein, and a category where what is sold may not be it.
- Dose
- No established human dose
- How often
- No established schedule
An anti-ageing molecule from the 1990s that broke sugar-protein crosslinks in rats and disappointed in people.
- Dose
- Research only
- How often
- No established pattern
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
- FDA response to citizen petition on the regulatory status of NMN, docket FDA-2023-P-0872(2025)FDA concludes NMN is not excluded from the dietary supplement definition, and explains the change in its reading of the race-to-market clause.
- FDA supplemental response on NDI 1259, the original exclusion(2022)The November 2022 determination that NMN was excluded.
Beyond these, 536 records are indexed. Browse the records