PNC-27_Dosage, benefits & legal status
Also known as PNC27, PNC-27 peptide, p53-MRP peptide
A lab-designed peptide with big cancer claims and no human trial in 25 years.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is PNC-27?
Plain language first. The technical label stays, but it never stands alone.Overview
The theory is careful and interesting, and it has never been tested in a person.
PNC-27 is a peptide built in a lab that is sold with claims about killing cancer cells. The idea behind it is real science: many cancer cells carry a protein called HDM-2 on their outer surface, and most healthy cells keep it tucked inside. PNC-27 was designed to stick to that protein and punch holes in the cell.
What it's used for
Sold online with anti-cancer claims. It has only ever been studied in cells and mice.
How does PNC-27 work?
What it does in the body, and where.The theory behind PNC-27 is genuinely clever, and it is worth understanding so you can see exactly where the evidence stops.
- 01Many cancer cells put a protein called HDM-2 on their surfaceHealthy cells make the same protein but keep it inside. That difference is what the whole design rests on.
- 02PNC-27 carries the piece of p53 that grabs HDM-2p53 is the body's own tumour-suppressing protein. Researchers copied the part of it that docks onto HDM-2.
- 03Once anchored, it opens a hole in the membraneThe cell spills its contents and dies. In lab dishes this happened to cancer cells and not to normal ones.
- 04Nothing after this step has been tested in a personEvery published result is from cells in a dish or from mice, and nearly all of it comes from the one laboratory that designed the peptide.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Killing cancer cells in a dish, which it does reliably in published lab workEarly research
- Shrinking tumors in mice, reported by the group that designed itEarly research
- Treating cancer in a person, which has never been testednone
The published record
Papers and trials about PNC-27
16 papers tagged human · 13 not reviews or lab · 0 clinical trial publications
Furthest stage reached: No clinical trial on record
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about PNC-27
Evidence
Category
Longevity and energy
Common vial
Varies
Half-life
Nothing published
How much, and do you cycle it?
The range, and whether you take breaks.Research only, varies. No established pattern No range
Nothing is known about how long it stays in a person or what repeated doses do.
Nothing publishedNo figure
Nothing published. A patent assumes the figure is measured in minutes without measuring it.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
PNC-27 starts at $79.00 across 17 vendors, typically $8.33 – $28.00 per mg.
17 listings, last read Oct 10, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized PNC-27 keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.If you or someone you care about has cancer, talk to an oncologist before considering anything you read about this peptide. Delaying or replacing treatment that works is the real risk here, and it is a much bigger risk than anything in the vial. There is no established dose because no dose has ever been tested in a person.
Solubility, computed: 38% charged residues, 44% hydrophobic. Water usually sufficient.
A first-pass rule from peptide manufacturers' guidance. It does not account for disulfide bridges, salt form or how the powder was dried, and it predicts what should be easy rather than what will happen in your vial.
Who should avoid it
- Anyone with cancer who is using it in place of, or alongside, real treatment without telling their oncologist
- Pregnancy
- Anyone expecting it to do what the marketing says, since no human evidence exists
Stop and get help
- Any reaction at all, since there is no safety record to compare against
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Unknown. No human study has recorded what happens to a person taking this.
- In cell studies it kills cells by bursting them open, which is a messier form of cell death than most cancer drugs cause. What that means in a body is untested.
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is PNC-27 approved?
And where the numbers on this page come from.No. PNC-27 is not approved for any use, anywhere. It is sold labeled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin (subcutaneous)
- Checked14 August 2026
- DoseFrom community reports. No regulator or trial established this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
What has happened recently
Not approved anywhere and never tested in a human trial. It appears in the National Cancer Institute drug dictionary, which records compounds with proposed activity and is not an endorsement or a sign of approval. Vendor pages sometimes cite that listing as if it were. The peptide was designed around the year 2000, so the absence of a trial after twenty-five years is itself information.
You can compare this against the whole library, or read how to check a seller.
What else is like PNC-27?
Others in Longevity and energy, side by side.If you're weighing PNC-27, it's worth reading Vesugen, Bronchogen, and NMN in the same class.
A lab-designed peptide with big cancer claims and no human trial in 25 years.
- Dose
- Research only
- How often
- Varies
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- Dose
- Varies (course-based)
- How often
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- Dose
- Varies (course-based)
- How often
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The NAD+ precursor the FDA banned, then un-banned on a technicality.
- Dose
- 250 up to 1,000 mg per day
- How often
- Daily
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- Why Does My Peptide Injection Itch or Welt
Injection-site irritation, a histamine reaction, or a true allergy, and how to tell them apart.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
Sources
- PNAS, PNC-27 binds HDM-2 in cancer cell membranes(2010)Describes the mechanism in cell lines. Normal cells that were engineered to carry HDM-2 on their surface became vulnerable to the peptide, which supports the proposed target.
- PubMed, PNC-27 induces necrosis of a human leukaemia cell line(2014)Cell-line work extending the mechanism to a leukemia line lacking p53.
Beyond these, 25 records are indexed. Browse the records