FOXO4-DRI_Dosage, benefits & legal status
Also known as FOXO4 D-retro-inverso
An experimental senolytic that clears aging cells, with no human safety data.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is FOXO4-DRI?
Plain language first. The technical label stays, but it never stands alone.Overview
It is a senolytic. That means it is designed to make worn-out zombie cells destroy themselves, so healthy tissue can take over. Animal results were striking. There is essentially no human safety data.
FOXO4-DRI is a specially built (D-retro-inverso) peptide that pries apart a partnership between the proteins FOXO4 and p53 inside aged cells.
What it's used for
An experimental peptide designed to clear out zombie aging cells for anti-aging, with striking animal results.
How does FOXO4-DRI work?
What it does in the body, and where.FOXO4-DRI is built backwards on purpose. D-retro-inverso means the amino acids are mirror images assembled in reverse order, which makes it resistant to being broken down.
- 01It separates FOXO4 from p53In senescent cells, that pairing is what keeps the cell alive when it should have died.
- 02The cell then self-destructsWhich is what senolytic means: clearing worn-out cells so healthy tissue can take over.
- 03Old mice recovered fur, kidney function, and staminaThe result that made this famous.
- 04It has never been given to a humanAnd some widely circulated lifespan-extension percentages attributed to it are simply fabricated.
A schematic of the compound's mechanism, not a diagnostic image.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Clearing worn-out 'zombie' cells to slow agingResearch only
- Hair regrowth and skin renewal, based on mouse studiesResearch only
The published record
17
Records indexed for FOXO4-DRI
8 in humans, 5 of them original studies.
Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 12 September 2026.
At a glance
Four things to know about FOXO4-DRI
Evidence
Research only
Category
Longevity and energy
Common vial
10 mg
Half-life
Nothing published
How much, and do you cycle it?
The range, and whether you take breaks.Research only, cycled. Commonly cycledCommunity practice
Cycled by convention rather than to a tested schedule. No published study establishes a block length or a break length for this one.
How long does it stay in the body?
The half-life, and where the figure comes from.Nothing publishedNo figure
Nothing published. The 2017 paper that made it well known measured what it did to cells, not how long it lasted.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
0 / 100 unitsFOXO4-DRI starts at $62.63 across 21 vendors, typically $11.06 – $27.50 per mg.
24 listings, last read Sep 5, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized FOXO4-DRI keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Any history of cancer
- Pregnancy
- There is essentially no human safety data, so nobody can tell you who should avoid it
Stop and get help
- Any severe or unexpected symptom, given the complete absence of human safety data
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Unknown in humans. Animal work showed temporary tissue effects, but there is no reliable human profile
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is FOXO4-DRI approved?
And where the numbers on this page come from.No. FOXO4-DRI is not approved for any use, anywhere. It is sold labelled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin or into a vein
- CheckedJuly 2026
What has happened recently
No human safety data exists. The striking results came from mouse studies, and nobody has established whether the same approach is safe in people.
You can compare this against the whole library, or read how to check a seller.
- DoseFrom research and community reports. No regulator has reviewed this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
- Reviewed22 July 2026
What else is like FOXO4-DRI?
Others in Longevity and energy, side by side.If you're weighing FOXO4-DRI, it's worth reading Vesugen, Bronchogen, and Orexin A in the same class.
An experimental senolytic that clears aging cells, with no human safety data.
- Dose
- Research only
- How often
- Cycled
A short bioregulator for blood-vessel health and aging, with thin evidence.
- Dose
- Varies (course-based)
- How often
- Courses
A bioregulator for lung and airway health, with thin evidence.
- Dose
- Varies (course-based)
- How often
- Courses
A peptide studied for wakefulness and daytime energy.
- Dose
- Research only
- How often
- As studied
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
- Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging, Cell (open repository copy)(2017)The paper that created the peptide and the only reason anyone has heard of it. FOXO4-DRI was designed to break the FOXO4 and p53 interaction so that senescent cells undergo apoptosis. Everything measured is cells and mice: it blunted doxorubicin toxicity, and it restored fitness, fur density and kidney function in fast-aging and naturally aged mice. The authors' own phrasing is that this held under conditions where the peptide was well tolerated in vivo, which is a dose-finding statement rather than a safety clearance. There is no human study of FOXO4-DRI, and this paper does not claim one.
Last reviewed 22 July 2026
Beyond these, 17 records are indexed. Browse the records