FOXO4-DRI_
Also known as FOXO4 D-retro-inverso
An experimental senolytic that clears aging cells, with no human safety data.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is FOXO4-DRI?
Plain language first. The technical label stays, but it never stands alone.Overview
FOXO4-DRI is a specially built (D-retro-inverso) peptide that pries apart a partnership between the proteins FOXO4 and p53 inside aged cells. In plain terms: it is a 'senolytic,' designed to make worn-out 'zombie' cells self-destruct so healthy tissue can take over, with striking animal results but essentially no human safety data.
What it's used for
An experimental peptide designed to clear out zombie aging cells for anti-aging, with striking animal results.
How does FOXO4-DRI work?
What it does in the body, and where.FOXO4-DRI is built backwards on purpose. D-retro-inverso means the amino acids are mirror images assembled in reverse order, which makes it resistant to being broken down.
- 01It separates FOXO4 from p53In senescent cells, that pairing is what keeps the cell alive when it should have died.
- 02The cell then self-destructsWhich is what senolytic means: clearing worn-out cells so healthy tissue can take over.
- 03Old mice recovered fur, kidney function, and staminaThe result that made this famous.
- 04It has never been given to a humanAnd some widely circulated lifespan-extension percentages attributed to it are simply fabricated.
A schematic of the compound's mechanism, not a diagnostic image.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Clearing worn-out 'zombie' cells to slow agingResearch only
- Hair regrowth and skin renewal, based on mouse studiesResearch only
How much, and do you cycle it?
The range, and whether you take breaks.Research only, cycled. Commonly cycledCommunity practice
Cycled by convention rather than to a tested schedule. No published study establishes a block length or a break length for this one.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
20 / 100 unitsHow do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized FOXO4-DRI keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.22 July 2026No human safety data exists. The striking results came from mouse studies, and nobody has established whether the same approach is safe in people.
Who should avoid it
- Any history of cancer
- Pregnancy
- There is essentially no human safety data, so nobody can tell you who should avoid it
Stop and get help
- Any severe or unexpected symptom, given the complete absence of human safety data
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Unknown in humans. Animal work showed temporary tissue effects, but there is no reliable human profile
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is FOXO4-DRI approved?
And where the numbers on this page come from.No. Not FDA-approved.
No human safety data exists. The striking results came from mouse studies, and nobody has established whether the same approach is safe in people.
- DoseFrom research and community reports. No regulator has reviewed this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Reviewed22 July 2026
What else is like FOXO4-DRI?
Others in Longevity and energy, side by side.If you're weighing FOXO4-DRI, it's worth reading MOTS-c, Epitalon, and NAD+ in the same class.
An experimental senolytic that clears aging cells, with no human safety data.
- Dose
- Research only
- How often
- Cycled
A shot people use for energy, metabolism, and healthy aging.
- Dose
- 5 up to 10 mg per week (start low, increase slowly)
- How often
- 1-3x per week
A longevity peptide taken in short courses for sleep and anti-aging.
- Dose
- 5 up to 10 mg per day (start low, increase slowly)
- How often
- 10-20 day courses
A cellular fuel taken for energy, focus, and anti-aging.
- Dose
- 50 up to 100 mg per dose (start low, increase slowly)
- How often
- 2-3x/week
10What these words mean
Show glossary +
What these words mean
- Titrate
- Starting at a low dose and increasing it slowly over time so your body adjusts and side effects stay mild.
- Subcutaneous
- An injection just under the skin, into the fat layer, usually with a short, thin insulin needle.
- Intramuscular (IM)
- An injection into a muscle, using a longer needle.
- Reconstitution
- Mixing a powdered peptide with liquid (bacteriostatic water) so it can be drawn into a syringe.
- Bacteriostatic water
- Sterile water with a tiny amount of preservative, used to mix powdered peptides.
- Concentration
- How strong the mixed peptide is, in milligrams per milliliter (mg/mL). More water makes it weaker; less water makes it stronger.
- Units (on the syringe)
- The marks on an insulin syringe. 100 units equals 1 mL. They measure how much liquid you draw, not the dose in milligrams.
- mcg and mg
- Units of dose. 1 milligram (mg) equals 1,000 micrograms (mcg).
- GLP-1
- A natural gut hormone that lowers appetite and blood sugar. Drugs that copy it, like semaglutide, are used for weight loss.
- Growth hormone secretagogue
- A compound that nudges your body to release more of its own growth hormone, rather than injecting the hormone itself.
- Half-life
- How long a compound stays active in your body. A longer half-life means you inject less often.
- Peptide vs small molecule
- A peptide is a short chain of amino acids. A few items here (like MK-677 or methylene blue) are small molecules, not true peptides, but people use them the same way.
- Research only
- No approved dose or use in people. Sold for research and not reviewed by the FDA for safety or quality.
- Investigational
- Still being tested in clinical trials and not yet approved or legally sold for general use.
- Banned in drug-tested sport
- Prohibited by the World Anti-Doping Agency (WADA); using it can disqualify a competing athlete.
Last reviewed 22 July 2026