Toremifene_Dosage, benefits & legal status
Also known as toremifene citrate, Fareston, TORE
A SERM with a boxed warning for a heart rhythm that can kill.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Toremifene?
Plain language first. The technical label stays, but it never stands alone.Overview
It blocks estrogen in breast tissue much as tamoxifen does, and it also stretches out the heart's electrical cycle.
Toremifene is a selective estrogen receptor modulator closely related to tamoxifen, approved for metastatic breast cancer in postmenopausal women with estrogen receptor-positive or unknown tumors.
What it's used for
A tamoxifen alternative sold on the research market for gynecomastia and post-cycle use, with a heart rhythm warning tamoxifen does not carry.
How does Toremifene work?
What it does in the body, and where.Toremifene has two separate actions, and only one of them is the point.
- 01It blocks estrogen receptors in breast tissueStructurally it is a close relative of tamoxifen and behaves much like it here.
- 02It also lengthens the QT intervalThis is the gap between the heart's electrical contraction and its reset, and stretching it can trigger torsades de pointes.
- 03The effect scales with dose and blood levelStrong CYP3A4 inhibitors and grapefruit juice matter for that reason. Both push the blood level up.
- 04Low potassium or magnesium makes it worseThe label requires these to be corrected before starting and checked during treatment.
A schematic of the compound's mechanism, not a diagnostic image.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
The published record
Papers and trials about Toremifene
368 papers tagged human · 244 not reviews or lab · 79 clinical trial publications
41 registered trials · 2 with posted results
Furthest stage reached: Approved in the US
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count. 467 papers and 41 trials indexed in detail.
At a glance
Four things to know about Toremifene
Evidence
FDA-approved
Category
Sexual and hormonal
Common vial
Varies
Half-life
3 to 7 days
How much, and do you cycle it?
The range, and whether you take breaks.60 mg per day, daily. Continuous, until the disease progresses FDA label
The label runs it daily with no planned break and no defined stopping point other than disease progression. Nothing studies the short courses it is sold for.
3 to 7 daysFDA label
The parent drug clears in 3 to 7 days. Its metabolites run far longer, 4 to 21 days, so the drug keeps acting well past the point the parent has gone.
Source: Fareston label, Clinical Pharmacology
You can compare this against the whole library to see where it sits.
What does it cost?
Typical dose and cost, in plain numbers.Toremifene is not injected
It is taken by mouth (oral). One 60 mg tablet once a day, continued until the disease progresses. That is the only dose on the label. Since the QT effect grows with dose and blood level, going above it is the specific thing the boxed warning is about.
How do you store it?
Before mixing, and after.Room temperature. Cool, dry, out of light.
Toremifene is taken as a pill or capsule. Keep it in its original container at room temperature, away from heat, humidity, and direct sun. No fridge or mixing needed. Check the expiration date on the bottle.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Congenital or acquired long QT syndrome
- Uncorrected low potassium or low magnesium
- Taking any other drug that prolongs the QT interval
- Taking a strong CYP3A4 inhibitor, and grapefruit juice should also be avoided
- Pregnancy
- Banned in drug-tested sport
Stop and get help
- Fainting, near-fainting, or a racing or pounding heartbeat
- A seizure
- Severe vomiting or diarrhea, which can drop potassium and magnesium
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Hot flushes
- Sweating
- Nausea
- Dizziness
- Vaginal discharge or bleeding, in anyone with a uterus
- Raised liver enzymes
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Toremifene approved?
And where the numbers on this page come from.Yes. Toremifene is FDA approved and available on prescription in the United States.
- Approval statusFDA-approved
- RouteBy mouth (oral)
- Checked24 August 2026
- DoseFrom the drug label. The manufacturer tested this range and a regulator reviewed it.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
What has happened recently
First approved in the US in 1997 for metastatic breast cancer in postmenopausal women with estrogen receptor-positive or unknown tumors. That is the whole indication. A QT prolongation boxed warning was added by supplement in 2011, and it states that the resulting torsades de pointes may cause fainting, seizure or death. The label contraindicates long QT syndrome and uncorrected low potassium or magnesium, and says to avoid other QT-prolonging drugs, strong CYP3A4 inhibitors and grapefruit juice. Prohibited in sport at all times by WADA under section S4.
Banned in drug-tested sport. Most research peptides are prohibited under WADA's S0 category, which covers any substance with no approval from any regulatory authority for human use. That means a compound can be banned without ever being named on the prohibited list. Check with your own anti-doping authority rather than assuming absence from the list means permitted.
You can compare this against the whole library, or read how to check a seller.
What else is like Toremifene?
Others in Sexual and hormonal, side by side.If you're weighing Toremifene, it's worth reading PT-141 (Bremelanotide), Kisspeptin, and Oxytocin in the same class.
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- 60 mg per day
- How often
- Daily
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- 18 up to 40 IU per dose
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Guides for this compound
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
Sources
- Fareston prescribing information, DailyMed(2024)1997 initial US approval, boxed warning, contraindications, 60 mg dose.
- FDA approval letter adding the QT boxed warning, Drugs@FDA(2011)Supplement approving the addition of QT prolongation to the boxed warning.
Beyond these, 508 records are indexed. Browse the records