Teduglutide (Gattex)_Dosage, benefits & legal status
Also known as Gattex, Revestive, GLP-2 analog, ALX-0600, Teduglutide, GLP-2
The real GLP-2 drug, and nothing to do with weight loss.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Teduglutide (Gattex)?
Plain language first. The technical label stays, but it never stands alone.Overview
It helps people whose intestine is too short to absorb enough food, so they need fewer hours hooked up to intravenous feeding. It is the only approved GLP-2 drug. It is worth knowing about for a second reason. Sellers use the name GLP-2 for tirzepatide, which is a different molecule with a different job.
Teduglutide is a copy of GLP-2, a gut hormone that tells the lining of the intestine to grow and absorb more.
What it's used for
A prescription drug for short bowel syndrome, taken to reduce how much intravenous feeding a person needs.
How does Teduglutide (Gattex) work?
What it does in the body, and where.GLP-2 is released by the gut after a meal and tells the intestinal lining to grow. Native GLP-2 is destroyed within minutes. Teduglutide is the same hormone with one change that stops that happening.
- 01One swapped amino acid buys it timeChanging the second residue blocks the enzyme DPP-4, which otherwise cuts native GLP-2 apart within minutes.
- 02It binds GLP-2 receptors in the gut wallThose receptors sit on cells in the intestinal lining and in nearby nerve and immune cells.
- 03The villi grow tallerVilli are the tiny finger-like projections that absorb nutrients. Taller villi and deeper crypts mean more surface area doing the work.
- 04More absorption means less intravenous feedingThat is the whole point. The measured outcome in trials was fewer liters and fewer hours per week on parenteral support.
Where this compound is thought to act.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Reducing the need for intravenous feeding in short bowel syndromeFDA-approved
- The same use in children aged one and olderFDA-approved
The published record
Papers and trials about Teduglutide (Gattex)
298 papers tagged human · 178 not reviews or lab · 29 clinical trial publications
50 registered trials · 20 with posted results
Furthest stage reached: Approved in the US
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about Teduglutide (Gattex)
Evidence
FDA-approved
Category
Healing and recovery
Common vial
5 mg
Half-life
1 to 2 hours, depending on who is taking it
How much, and do you cycle it?
The range, and whether you take breaks.0.05 mg per kg of body weight per day, daily. Continuous daily use, with no planned break FDA label
The benefit is regrowth of the intestinal lining, which reverses if the drug stops. Trials ran continuously and the label sets no course length.
1 to 2 hours, depending on who is taking itFDA label
Four figures on one label. About 2 hours in healthy adults, 1.3 hours in adults with short bowel syndrome, 1 hour in adolescents and 0.7 hours in children aged 1 to 11. The condition it treats shortens it. Native GLP-2 lasts about 7 minutes, and the single amino acid swap in teduglutide is what buys the rest.
Source: Gattex label section 12.3, DailyMed setid 66b69c1e-b25c-44d3-b5ff-1c1de9a516fa
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Dosed by body weight, so the calculator cannot produce a draw for it.
Teduglutide (Gattex) starts at $80.00 across 6 vendors, typically $3.67 – $17.80 per mg.
18 listings, last read Oct 10, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Teduglutide (Gattex) keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Dosed by body weight, so there is no single number. At 0.05 mg per kilogram, a 70 kg adult takes 3.5 mg a day. It is supplied in 5 mg single-dose vials, usually in a 30-vial kit, and anyone needing more than 3.8 mg a day uses two kits. Do not confuse this with anything sold as "GLP-2" by a peptide vendor. Those vials are tirzepatide.
Solubility, computed: 30% charged residues, 39% hydrophobic. Water usually sufficient.
A first-pass rule from peptide manufacturers' guidance. It does not account for disulfide bridges, salt form or how the powder was dried, and it predicts what should be easy rather than what will happen in your vial.
Who should avoid it
- Active cancer of the digestive tract
- Any cancer diagnosed within the past five years, without specialist advice
- Pregnancy, without specialist advice
- Anyone who has not had the required colonoscopy
Stop and get help
- Blood in the stool or worsening stomach pain
- Signs of a blocked bowel, such as vomiting and no bowel movement
- Yellowing of the skin or eyes
- Signs of an allergic reaction such as face or throat swelling
Common effects
- Stomach pain and swelling
- Nausea and vomiting
- Injection-site reactions
- Fluid overload, meaning puffiness or swelling
- Upper respiratory infections
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Teduglutide (Gattex) approved?
And where the numbers on this page come from.Yes. Teduglutide (Gattex) is FDA approved and available on prescription in the United States.
- Approval statusFDA-approved
- RouteUnder the skin (subcutaneous)
- Checked22 September 2026
- DoseFrom the drug label. The manufacturer tested this range and a regulator reviewed it.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
What has happened recently
FDA-approved in 2012 for adults with short bowel syndrome, and extended in 2019 to children aged one and older. It is the only approved GLP-2 analog. The label carries a warning about polyps: a colonoscopy is required within six months before starting and again after the first year, because the same growth signal that thickens the intestinal lining can accelerate abnormal growth.
You can compare this against the whole library, or read how to check a seller.
What else is like Teduglutide (Gattex)?
Others in Healing and recovery, side by side.If you're weighing Teduglutide (Gattex), it's worth reading Cerebrolysin, Ovagen, and Chonluten in the same class.
The real GLP-2 drug, and nothing to do with weight loss.
- Dose
- 0.05 mg per kg of body weight per day
- How often
- Daily
An injectable brain-peptide blend used abroad for stroke and dementia recovery.
- Dose
- 10 up to 50 mL per day (start low, increase slowly)
- How often
- 10-20 day cycles
A bioregulator for liver and digestive support, with thin evidence.
- Dose
- Varies (course-based)
- How often
- Courses
A bioregulator for lung and gut-lining support, with thin evidence.
- Dose
- Varies (course-based)
- How often
- Courses
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- Why Does My Peptide Injection Itch or Welt
Injection-site irritation, a histamine reaction, or a true allergy, and how to tell them apart.
Sources
- FDA, GATTEX (teduglutide) prescribing information(2012)0.05 mg/kg once daily subcutaneously. 88% bioavailability, peak at 3 to 5 hours. Colonoscopy required before starting and at one year.
- Takeda, FDA approval for children aged 1 and older(2019)Indication extended to pediatric patients. Described as the only approved GLP-2 analog.
Beyond these, 417 records are indexed. Browse the records