Abaloparatide (Tymlos)_Dosage, benefits & legal status
Also known as Tymlos, BA058
A bone-building drug that completes the family around teriparatide.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Abaloparatide (Tymlos)?
Plain language first. The technical label stays, but it never stands alone.Overview
A daily injection that builds new bone rather than just slowing its loss. It copies a different hormone from teriparatide and does much the same job.
Abaloparatide, a synthetic analog of parathyroid hormone-related protein (PTHrP 1-34), acting as an anabolic agent at the PTH1 receptor. FDA-approved 28 April 2017 as Tymlos for postmenopausal women with osteoporosis at high risk of fracture, with later expansion to men. Approval included enhanced pharmacovigilance for osteosarcoma reports, scheduled for reassessment fifteen years after approval.
What it's used for
A daily injection for osteoporosis in people at high risk of fracture.
How does Abaloparatide (Tymlos) work?
What it does in the body, and where.Abaloparatide sits next to teriparatide in this library, and the difference between them is which hormone each copies.
- 01Anabolic, not antiresorptiveMost osteoporosis drugs slow the breakdown of bone. Abaloparatide and teriparatide stimulate new bone formation, which is a different and more demanding thing to achieve.
- 02It copies PTHrP rather than PTHTeriparatide is parathyroid hormone fragment 1-34. Abaloparatide is an analog of parathyroid hormone-related protein. Both act at the same receptor with different binding behavior.
- 03Intermittent dosing is the trickContinuous parathyroid hormone signaling breaks bone down. A single daily pulse builds it up. The entire drug class depends on that distinction, which is why the dosing schedule is not negotiable.
- 04The osteosarcoma question shaped the labelRodent studies in this drug class raised bone cancer concerns, and the FDA required enhanced pharmacovigilance for reports of osteosarcoma with abaloparatide, to be reassessed fifteen years after approval.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Postmenopausal osteoporosis at high risk of fractureFDA-approved
- Osteoporosis in men at high risk of fractureFDA-approved
- General bone health or fracture healing outside those settingsnone
The published record
Papers and trials about Abaloparatide (Tymlos)
263 papers tagged human · 124 not reviews or lab · 36 clinical trial publications
25 registered trials · 11 with posted results
Furthest stage reached: Approved in the US
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count. 400 papers and 25 trials indexed in detail.
At a glance
Four things to know about Abaloparatide (Tymlos)
Evidence
FDA-approved
Category
Healing and recovery
Common vial
Varies
Half-life
1 to 2 hours
How much, and do you cycle it?
The range, and whether you take breaks.Set by the label, once daily. Set by the prescription FDA label
This is a prescription drug. Duration and schedule are set by the label and the prescriber, not by a cycling convention.
1 to 2 hoursFDA label
The figure changed between label versions. The original 2017 Tymlos label states a mean half-life of 1.7 hours. The 2024 revision states approximately 1 hour. Both are the same drug and the same section of the label, so a figure quoted without its label year is incomplete.
Source: Tymlos label section 12.3. The 2017 label gives 1.7 hours, the 2024 revision gives about 1 hour.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Abaloparatide (Tymlos) keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Solubility, computed: 41% charged residues, 38% hydrophobic. Water usually sufficient.
A first-pass rule from peptide manufacturers' guidance. It does not account for disulfide bridges, salt form or how the powder was dried, and it predicts what should be easy rather than what will happen in your vial.
Who should avoid it
- Pregnancy or breastfeeding
- Any condition raising the baseline risk of osteosarcoma, including Paget's disease of bone and prior radiation to the skeleton
- High blood calcium
- Use outside a prescription, where no label governs the dose or the treatment duration
Stop and get help
- Fainting, or dizziness severe enough to cause a fall
- Signs of high blood calcium, including persistent nausea, vomiting, constipation or confusion
- Signs of an allergic reaction, including facial or throat swelling or trouble breathing
- New or persistent bone pain
Common effects
- Dizziness and light-headedness, particularly after the first doses
- Palpitations
- Nausea
- Headache
- Injection site reactions
- Raised blood calcium
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Abaloparatide (Tymlos) approved?
And where the numbers on this page come from.Yes. Abaloparatide (Tymlos) is FDA approved and available on prescription in the United States.
- Approval statusFDA-approved
- RouteUnder the skin (subcutaneous)
- Checked24 August 2026
- DoseFrom the drug label. The manufacturer tested this range and a regulator reviewed it.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesNone traced yet.
What has happened recently
FDA-approved 28 April 2017 as Tymlos for postmenopausal osteoporosis at high risk of fracture, later expanded to men with osteoporosis. Prescription only. The approval included enhanced pharmacovigilance for osteosarcoma reports.
You can compare this against the whole library, or read how to check a seller.
What else is like Abaloparatide (Tymlos)?
Others in Healing and recovery, side by side.If you're weighing Abaloparatide (Tymlos), it's worth reading Calcitonin (salmon), Cerluten, and Linaclotide (Linzess) in the same class.
A bone-building drug that completes the family around teriparatide.
- Dose
- Set by the label
- How often
- Once daily
A bone hormone borrowed from salmon, and the weakest option in its own category.
- Dose
- Set by the label
- How often
- Daily, by spray or injection
A bioregulator for brain and nerve support, with thin evidence.
- Dose
- Varies (course-based)
- How often
- Courses
An approved oral peptide for constipation that works in the gut and barely reaches the blood.
- Dose
- 72, 145 or 290 mcg once daily (label)
- How often
- Once daily
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
Sources
No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence
Beyond these, 425 records are indexed. Browse the records