Peptide Decoding
All groups · Goal

Peptides for healing and injury recovery

Compounds used for injury, tendon, joint, and gut repair.

10 approved by the FDA, 4 available on prescription or through a compounding pharmacy, 1 approved in other countries but not in the US, 34 with no approval anywhere.

This group is where the gap between how confident people sound and what has actually been tested is widest. BPC-157 and TB-500 are discussed as if the dosing were worked out, and neither has completed a published human trial. The tendon and gut results everyone quotes came from rats.

That does not make the compounds useless, but it does change what a dose means. Every protocol circulating online was reverse-engineered from animal work by converting milligrams per kilogram, which is not how drug dosing translates between species. Nobody has established a therapeutic range in a person.

The members with real clinical histories were approved for something other than injury repair. Teriparatide, abaloparatide and calcitonin treat osteoporosis, teduglutide treats short bowel syndrome, pentosan is prescribed for bladder pain, and Cerebrolysin is used after stroke in several countries outside the United States. Their pages give the detail. The rest are research chemicals with an enthusiastic user base and thin paperwork.

Healing & recoveryResearch only
BPC-157
Repair peptide

A 15-amino-acid chain based on a stomach protein, used after injuries. Almost all the evidence is from animals.

Healing & recoveryResearch only
TB-500 / Thymosin Beta-4
Repair peptide

A fragment of the repair protein thymosin beta-4, used for muscle and tendon healing. Most evidence is from animals.

InflammationResearch only
KPV
Anti-inflammatory tripeptide

The three-amino-acid tail of the hormone alpha-MSH, sold to calm gut and skin without tanning. No human trials exist.

Healing & recoveryResearch only
BPC-157 + TB-500
BPC-157 + TB-500 combo

The two most popular healing peptides in one vial. 'Wolverine' is a community nickname, and ratios vary by vendor.

Skin & recoveryResearch only
GLOW blend
GHK-Cu + BPC-157 + TB-500 combo

Three peptides in one vial: GHK-Cu for skin, plus BPC-157 and TB-500 for tissue repair.

Skin & recoveryResearch only
KLOW blend
GLOW + KPV combo

The GLOW blend (GHK-Cu, BPC-157, TB-500) with KPV added for anti-inflammatory effect.

Nerve pain & healingInvestigational
ARA-290 (Cibinetide)
EPO-derived peptide

Carved from EPO to keep its repair signal without thickening the blood. Reached human trials for nerve pain.

Immune & inflammationResearch only
VIP (Vasoactive Intestinal Peptide)
Neuropeptide

A natural signal that relaxes airways and calms the immune system. Used as a nasal spray, and can lower blood pressure.

Joint / cartilageResearch only
Cartalax
Bioregulator peptide

A 3-amino-acid Khavinson peptide sold for cartilage and joints, with very little human research.

Recovery / nerveResearch only
Cortagen
Bioregulator peptide

A short Khavinson peptide based on a brain-tissue peptide, taken for nerve recovery on very little human research.

Liver & agingResearch only
Livagen
Bioregulator (KEDA)

A 4-amino-acid Khavinson peptide sold for liver support, with very little human research.

Liver & gutResearch only
Ovagen
Bioregulator peptide

A short Khavinson peptide sold for liver and digestive support, with very little human research.

Brain recoveryClinical use
Cerebrolysin
Brain peptide mixture

A mix of small peptides from pig brain tissue, with the strongest human evidence in its group for stroke and dementia.

Healing & recoveryResearch only
Coremend blend (TB-500 / BPC-157 / KPV)
TB-500 + BPC-157 + KPV blend

A vendor name for TB-500, BPC-157 and KPV in one vial. It sits one component short of KLOW.

Lungs & gutResearch only
Chonluten
Bioregulator peptide

A 3-amino-acid Khavinson peptide sold for lung and gut-lining support, with very little human research.

Healing & recoveryResearch only
BPC-157 + TB-500 + Cartalax
BPC-157 + TB-500 + Cartalax blend

BPC-157, TB-500 and Cartalax in one vial, typically 10 mg of each. Sold as Regeno and as Deadpool. The third is aimed at cartilage.

Healing & recoveryResearch only
PDA (Pentadeca Arginate)
BPC-157 relative

A very new arginate-salt cousin of BPC-157, aimed at the same repair job with more stability.

Recovery / nerveResearch only
B7-33
Relaxin analog

A single-chain piece of the hormone relaxin, built to keep its anti-scarring activity and be simpler to make.

Brain recoveryClinical use
Cerebroprotein Hydrolysate
Tissue peptide extract

A generic name for pig-brain peptide mixtures used in hospitals in India and China. A vendor's vial is none of those.

Bladder & agingResearch only
Vesilute
Bioregulator (ED)

A 2-amino-acid Khavinson peptide sold for bladder lining support, with very little human research.

Healing & recoveryResearch only
Ac-SDKP (TB-500 Fragment 1-4)
Tetrapeptide fragment of thymosin beta-4

The first four residues of TB-500, and something the body already makes. Its anti-scarring effects are in animal models.

Gut / leaky gutInvestigational
Larazotide
Tight-junction regulator

Tightens the junctions between gut-lining cells. Studied mainly for celiac disease, and not absorbed into the body.

Bone strengthFDA-approved
Teriparatide (Forteo)
Parathyroid hormone fragment

The working part of parathyroid hormone. It builds new bone, where most osteoporosis drugs only slow the loss.

Fracture and wound healingInvestigational
TP508 (rusalatide)
Thrombin-derived repair peptide (23-residue amidated peptide)

A 23-residue piece of thrombin sold for fracture and wound healing. Its 503-patient phase 3 failed, and every human dose was micrograms, given locally.

Gut absorptionFDA-approved
Teduglutide (Gattex)
GLP-2 analog

The only approved GLP-2 drug, for people with too little intestine. Not the 'GLP-2' sellers use to mean tirzepatide.

Bone densityFDA-approved
Abaloparatide (Tymlos)
PTHrP analog

Builds new bone the way teriparatide does, from a different parent hormone. Approved for osteoporosis.

Gut absorptionInvestigational
Apraglutide
GLP-2 receptor agonist (modified peptide)

A once-weekly GLP-2 injection for short bowel syndrome whose phase 3 met its main goal, though the FDA wants a second trial, now recruiting.

Reduce blood loss in heart surgeryFDA-approved
Aprotinin
Protease inhibitor (58-residue bovine protein)

A 58-residue cow protein that cuts bleeding in heart surgery. Pulled worldwide in 2007 over a mortality signal, then reinstated in Europe after regulators judged that study unreliable.

Prevent clots during heart proceduresFDA-approved
Bivalirudin (Angiomax)
Direct thrombin inhibitor (hirudin-based peptide)

A 20-residue thrombin blocker modeled on the leech anticoagulant hirudin, given by drip during angioplasty and stenting.

Bone & calciumFDA-approved
Calcitonin (salmon)
Calcitonin analog

Lowers blood calcium and slows bone breakdown. Approved for osteoporosis, and the least effective drug in that space.

Replace missing parathyroid hormoneInvestigational
Canvuparatide
Parathyroid hormone prodrug (weekly)

A once-weekly parathyroid hormone for people whose parathyroid glands do not work, now in a phase 3; the approved options are daily.

Brain & nervesResearch only
Cerluten
Bioregulator peptide

A Khavinson bioregulator drawn from nerve tissue, sold for brain and nerve support on very little human research.

Limit brain injuryInvestigational
CN-105
Apolipoprotein E mimetic (capped pentapeptide)

An experimental five-amino-acid mimic of apolipoprotein E, given by drip in the hospital after brain bleeds and around surgery; no trial has yet shown benefit.

Prevent clots in heart arteriesFDA-approved
Eptifibatide
Glycoprotein IIb/IIIa inhibitor (cyclic peptide)

A cyclic peptide that stops platelets clumping, given by drip during heart attacks and stent procedures. Designed from a rattlesnake venom protein.

Gut absorptionInvestigational
Glepaglutide (Zeydovio)
GLP-2 receptor agonist (peptide with a six-lysine tail)

A twice-weekly GLP-2 injection from Zealand Pharma for short bowel syndrome, recommended for EU approval in September 2026; the FDA wants another trial.

Heal the eye surfaceInvestigational
Lacripep
Syndecan-1-binding tear peptide (linear lacritin fragment)

An investigational eye drop made from a 19-residue fragment of lacritin, a natural tear protein, now in phase 2 for neurotrophic keratitis.

Constipation and IBS-CFDA-approved
Linaclotide (Linzess)
Guanylate cyclase-C agonist (oral peptide)

An FDA-approved capsule peptide that stays in the gut and draws water into the bowel to treat constipation.

Protect the brain during a strokeInvestigational
Nerinetide (NA-1)
PSD-95 inhibitor (cell-penetrating peptide)

A stroke neuroprotectant that missed its main goal in three large trials; a case study in subgroup findings that did not survive retesting.

Treat lung fibrosisInvestigational
ORJ-001 (NP-201)
Beta-1 integrin agonist (synthetic 19-residue peptide)

An experimental injected peptide for the lung scarring of idiopathic pulmonary fibrosis, tested so far only in healthy volunteers and in mice.

Replace parathyroid hormoneFDA-approved
Palopegteriparatide (Yorvipath)
Parathyroid hormone replacement (PEGylated peptide prodrug)

A daily parathyroid hormone replacement for adults with hypoparathyroidism, built as a prodrug that slowly releases teriparatide; FDA-approved in August 2024.

Joint / bladderClinical use
Pentosan Polysulfate (PPS)
SPGAG (not a true peptide)

Acts like the natural lubricant in joints and the bladder lining. Used for arthritis and painful bladder.

Ulcerative colitisInvestigational
PL8177
MC1R agonist (cyclic heptapeptide, colon-release capsule)

A seven-residue cyclic MC1R peptide in a capsule that releases in the colon. Its ulcerative colitis trial stopped at 12 patients, and the company reported a p-value from a study it called underpowered.

Dry eye diseaseInvestigational
PL9643
Melanocortin pan-agonist (eye drop)

A melanocortin eye drop for dry eye. Its 575-patient phase 3 missed both co-primary endpoints as planned, and hit one only after the analysis was adjusted for age and sex.

Relieve chronic constipationFDA-approved
Plecanatide (Trulance)
Guanylate cyclase-C agonist (oral peptide)

Linaclotide's rival: a copy of the gut hormone uroguanylin with one change, approved for chronic constipation and IBS with constipation.

Tissue repairInvestigational
Redasemtide
HMGB1 fragment peptide (regenerative)

Shionogi's IV fragment of the HMGB1 protein, meant to call the body's own stem cells to damaged tissue.

Eyes & agingResearch only
Retinalamin
Tissue peptide extract

A cattle retina extract developed in Russia and used in eye clinics there, from the same family as Cortexin.

Joints & cartilageResearch only
Sigumir
Bioregulator peptide

A Khavinson bioregulator drawn from cartilage, sold for bone and joint health on very little human research.

Recovery after ischemic strokeClinical use
Sovateltide
Endothelin-B receptor agonist (peptide)

A stroke drug approved only in India: a 14-residue fragment of endothelin-1 that switches on the B receptor, now in a US phase 3.

Repair claimsResearch only
Thymosin Beta-15
Beta-thymosin

A relative of the protein TB-500 comes from. Sold for repair, though the published work is on prostate tumor spread.

Common questions

Is there human evidence for healing peptides?

Very little. Most of the well-known repair peptides have only animal and cell studies behind them. That does not mean they do nothing, but it does mean no dose has been validated in people.

What is the difference between BPC-157 and TB-500?

BPC-157 is a gastric peptide fragment studied mostly for gut and tendon models; TB-500 is a fragment of thymosin beta-4 studied for cell migration and tissue repair. They are often stacked, but neither has human trial support.

Can you buy healing peptides legally?

They are generally sold as research chemicals, not medicines. Selling them for human use is not legal in most countries, and purity varies by vendor.