Sigumir_Dosage, benefits & legal status
A bioregulator for bone, joint, and cartilage health, with thin evidence.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Sigumir?
Plain language first. The technical label stays, but it never stands alone.Overview
It is marketed for bone, joint, and cartilage health, but there is very little real human research behind it.
Sigumir is a peptide 'bioregulator' from the Russian Khavinson family, drawn from cartilage.
What it's used for
A bioregulator aimed at bone, joint, and cartilage health, taken in short courses.
How does Sigumir work?
What it does in the body, and where.Sigumir, like Cerluten, is a crude tissue extract rather than a defined peptide, drawn from cartilage.
- 01It is a cartilage extractMarketed for bone and joint support.
- 02No citable human evidence, and no defined sequenceComposition is uncharacterised and batch-dependent.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Bone, joint, and cartilage healthResearch only
The published record
3
Records indexed for Sigumir
3 in humans, 2 of them original studies.
Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 12 September 2026.
At a glance
Four things to know about Sigumir
Evidence
Research only
Category
Healing and recovery
Common vial
10 mg
Half-life
Nothing published
How much, and do you cycle it?
The range, and whether you take breaks.Varies (course-based), courses. Courses of 10 to 20 days, repeated two or three times a yearCommunity practice
The course structure is how the Khavinson protocols specify these and how they are sold. No trial has compared course dosing against continuous use, or established how long the gap between courses should be.
How long does it stay in the body?
The half-life, and where the figure comes from.Nothing publishedNo figure
No half-life has ever been published for any of the Russian bioregulator peptides, in people or in animals. The research behind them, mostly from one group in St Petersburg, measures effects on tissue, gene activity and lifespan. None of it measures how long the peptide stays in the body.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
0 / 100 unitsHow do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Sigumir keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Pregnancy or breastfeeding
- Any prescription medicine you take regularly, without checking for interactions first
- Anyone who wants established safety data, because none exists for this compound in humans
Stop and get help
- Spreading hives, swelling of the face or throat, or trouble breathing, which can happen with any injection and is a medical emergency
- Redness, heat, or pus at the injection site, which can signal infection
- Any severe or unexpected symptom
- Anything unusual, since there is no known safety profile to compare it against
Common effects
- Little human evidence.
- Redness, soreness, or a small bump at the injection site
- Beyond the above, unknown. There is no reliable human data on what this compound commonly causes
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Sigumir approved?
And where the numbers on this page come from.No. Sigumir is not approved for any use, anywhere. It is sold labelled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin, or by mouth
- CheckedJuly 2026
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
You can compare this against the whole library, or read how to check a seller.
- DoseFrom research and community reports. No regulator has reviewed this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
- Reviewed22 July 2026
What else is like Sigumir?
Others in Healing and recovery, side by side.If you're weighing Sigumir, it's worth reading BPC-157 + TB-500, Teduglutide (Gattex), and Teriparatide (Forteo) in the same class.
A bioregulator for bone, joint, and cartilage health, with thin evidence.
- Dose
- Varies (course-based)
- How often
- Courses
The two best-known healing peptides in one shot, at a ratio that changes by vendor.
- Dose
- 0.25 up to 0.5 mg BPC-157 per day (the TB-500 follows your ratio)
- How often
- Varies
The real GLP-2 drug, and nothing to do with weight loss.
- Dose
- 0.05 mg per kg of body weight per day
- How often
- Daily
The bone drug that builds new bone instead of just slowing the loss.
- Dose
- 20 mcg per day
- How often
- Daily
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
- Khavinson et al., Peptide Regulation of Gene Expression: A Systematic Review (Molecules 26:7053)(2021)This is an extract of cartilage, not a single defined molecule, and this review is the originating group's own account of that class. It calls them cytomedines, peptide fractions isolated from animal organs, and states that their action is specific to the cell populations they were taken from. That claim is the whole reason a cartilage extract is sold for joints and cartilage, so it is worth knowing where it comes from and what supports it. The review is written by Khavinson and colleagues at the Saint Petersburg institute where these products originated, so it is the source group making its own case, and the evidence behind it is cell culture, animal work and molecular modelling rather than trials in people.
- FDA, bulk drug substances nominated for use in compounding under section 503A, updated 14 May 2026(2026)A cartilage extract sold in the United States has no regulatory standing here at all. Two peptides from this same Russian family, Epitalon and Semax, went before FDA's Pharmacy Compounding Advisory Committee in July 2026. The products sold alongside them, including this one, appear in none of the three categories on this list, which has been open to nominations since 2013 and drew over two thousand submissions.
Last reviewed 22 July 2026
Beyond these, 3 records are indexed. Browse the records