Larazotide_Dosage, benefits & legal status
Also known as AT-1001, larazotide acetate, INN-202
An oral peptide studied for sealing a leaky gut, mainly in celiac disease.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Larazotide?
Plain language first. The technical label stays, but it never stands alone.Overview
It works locally in the intestine to seal a 'leaky' gut barrier and has been studied mainly for celiac disease. It is not absorbed into the body.
Larazotide is an 8-amino-acid peptide that tightens the junctions between the cells lining your gut.
What it's used for
An oral peptide studied for sealing a leaky gut lining, mainly for celiac disease. It works in the gut and is not absorbed.
How does Larazotide work?
What it does in the body, and where.Larazotide is unusual here: it is designed specifically not to be absorbed. It works on the inside surface of your gut and never enters the bloodstream.
- 01It tightens the junctions between gut lining cellsThe seals between cells that determine what can pass from the gut into the body.
- 02It works in the gut cavity, not in your bloodWhich limits both its effects and its risks to the intestine itself.
- 03Celiac disease is what it was built forReducing the symptoms that break through when someone eating gluten-free encounters small amounts anyway.
- 04Phase 3 did not meet its endpointIt has been through large trials, which is more than most compounds here can say, and it did not clearly work.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Celiac disease symptoms despite a gluten-free diet, where the Phase 3 trial was stopped in 2022 for lack of benefitInvestigational
- Sealing a leaky gut lining generallyEarly research
The published record
Papers and trials about Larazotide
Searched: larazotide, larazotide acetate, INN-202, AT-1001, zonulin, celiac, tight junction.
63 papers tagged human · 18 not reviews or lab · 4 clinical trial publications
31 registered trials · 12 with posted results
Furthest stage reached: Phase 3, results posted
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about Larazotide
Evidence
Investigational
Category
Healing and recovery
Common vial
5 mg
Half-life
Not the right question
How much, and do you cycle it?
The range, and whether you take breaks.0.5 mg per dose, before meals. Not cycled in the trials Trial dose
In the trials this was given continuously for the whole study period. No on/off schedule has been tested, so there is nothing to report beyond that.
Not the right questionNo figure
Larazotide is designed to work inside the gut and not be absorbed into the bloodstream at all, so a blood half-life does not describe what it does.
Source: Paterson BM, et al. Aliment Pharmacol Ther 2007;26:757-766
You can compare this against the whole library to see where it sits.
What does it cost?
Typical dose and cost, in plain numbers.The products priced here are not injected
The listed products are taken by mouth (oral).
Larazotide starts at $50.00 across 5 vendors, typically $10.00 per mg.
5 listings, last read Oct 24, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Room temperature. Cool, dry, out of light.
Larazotide is taken as a pill or capsule. Keep it in its original container at room temperature, away from heat, humidity, and direct sun. No fridge or mixing needed. Check the expiration date on the bottle.
What are the side effects and cautions?
Known cautions and warnings for this compound.Solubility, computed: 25% charged residues, 50% hydrophobic. Water usually sufficient.
A first-pass rule from peptide manufacturers' guidance. It does not account for disulfide bridges, salt form or how the powder was dried, and it predicts what should be easy rather than what will happen in your vial.
Who should avoid it
- No formal contraindications established
Stop and get help
- Signs of an allergic reaction
Common effects
- Comparable to placebo in trials, since it works in the gut and is not absorbed
- Its Phase 3 celiac trial was stopped in 2022 because it did not work well enough, not because it was unsafe
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Larazotide approved?
And where the numbers on this page come from.No. Larazotide is not approved anywhere and is currently in company-run clinical trials. There is no legal route to obtain it outside a trial.
- Approval statusInvestigational
- RouteBy mouth (oral)
- Checked22 July 2026
- DoseFrom published clinical trials. Not approved by a regulator for this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesNone traced yet.
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
You can compare this against the whole library, or read how to check a seller.
What else is like Larazotide?
Others in Healing and recovery, side by side.If you're weighing Larazotide, it's worth reading Teriparatide (Forteo), TP508 (rusalatide), and Teduglutide (Gattex) in the same class.
An oral peptide studied for sealing a leaky gut, mainly in celiac disease.
- Dose
- 0.5 mg per dose
- How often
- Before meals
The bone drug that builds new bone instead of just slowing the loss.
- Dose
- 20 mcg per day
- How often
- Daily
A 23-residue copy of one stretch of thrombin, the clotting enzyme, with no clotting activity of its own. It sped wrist-fracture healing in a 90-patient trial, then failed a 503-patient phase 3 and a 274-patient dose-finding trial.
- Dose
- 1 to 100 mcg placed locally (trials)
- How often
- Once at fracture surgery, or twice weekly on an ulcer
The real GLP-2 drug, and nothing to do with weight loss.
- Dose
- 0.05 mg per kg of body weight per day
- How often
- Daily
Guides for this compound
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence
Beyond these, 84 records are indexed. Browse the records