Larazotide_
Also known as AT-1001, larazotide acetate, INN-202
An oral peptide studied for sealing a leaky gut, mainly in celiac disease.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Larazotide?
Plain language first. The technical label stays, but it never stands alone.Overview
Larazotide is an 8-amino-acid peptide that tightens the junctions between the cells lining your gut. In plain terms: it works locally in the intestine to seal a 'leaky' gut barrier and has been studied mainly for celiac disease. It is not absorbed into the body.
What it's used for
An oral peptide studied for sealing a leaky gut lining, mainly for celiac disease. It works in the gut and is not absorbed.
How does Larazotide work?
What it does in the body, and where.Larazotide is unusual here: it is designed specifically not to be absorbed. It works on the inside surface of your gut and never enters the bloodstream.
- 01It tightens the junctions between gut lining cellsThe seals between cells that determine what can pass from the gut into the body.
- 02It works in the gut cavity, not in your bloodWhich limits both its effects and its risks to the intestine itself.
- 03Celiac disease is what it was built forReducing the symptoms that break through when someone eating gluten-free encounters small amounts anyway.
- 04Phase 3 did not meet its endpointIt has been through large trials, which is more than most compounds here can say, and it did not clearly work.
Where this compound is thought to act.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Celiac disease symptoms despite a gluten-free diet, where the Phase 3 trial was stopped in 2022 for lack of benefitInvestigational
- Sealing a leaky gut lining generallyEarly research
How much, and do you cycle it?
The range, and whether you take breaks.0.5 mg per dose, before meals. Not cycled in the trialsTrial dose
In the trials this was given continuously for the whole study period. No on/off schedule has been tested, so there is nothing to report beyond that.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Larazotide is not injected
It is taken by mouth (oral).
How do you store it?
Before mixing, and after.Room temperature. Cool, dry, out of light.
Larazotide is taken as a pill or capsule. Keep it in its original container at room temperature, away from heat, humidity, and direct sun. No fridge or mixing needed. Check the expiration date on the bottle.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- No formal contraindications established
Stop and get help
- Signs of an allergic reaction
Common effects
- Comparable to placebo in trials, since it works in the gut and is not absorbed
- Its Phase 3 celiac trial was stopped in 2022 because it did not work well enough, not because it was unsafe
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Larazotide approved?
And where the numbers on this page come from.No. Not FDA-approved.
It is still being studied; a regulator has not cleared it for this use.
- DoseFrom published clinical trials. Not approved by a regulator for this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Reviewed22 July 2026
What else is like Larazotide?
Others in Healing and recovery, side by side.If you're weighing Larazotide, it's worth reading PDA (Pentadeca Arginate), GLOW blend, and KLOW blend in the same class.
An oral peptide studied for sealing a leaky gut, mainly in celiac disease.
- Dose
- 0.5 mg per dose
- How often
- Before meals
A newer, more stable cousin of BPC-157 for faster healing.
- Dose
- 0.25 up to 0.5 mg per day (start low, increase slowly)
- How often
- 1-2x daily
A popular skin-and-healing blend of three peptides in one shot.
- Dose
- Per blend (mcg each)
- How often
- Daily
The GLOW blend plus an anti-inflammatory peptide, an all-in-one recovery stack.
- Dose
- Per blend (mcg each)
- How often
- Daily
10What these words mean
Show glossary +
What these words mean
- Titrate
- Starting at a low dose and increasing it slowly over time so your body adjusts and side effects stay mild.
- Subcutaneous
- An injection just under the skin, into the fat layer, usually with a short, thin insulin needle.
- Intramuscular (IM)
- An injection into a muscle, using a longer needle.
- Reconstitution
- Mixing a powdered peptide with liquid (bacteriostatic water) so it can be drawn into a syringe.
- Bacteriostatic water
- Sterile water with a tiny amount of preservative, used to mix powdered peptides.
- Concentration
- How strong the mixed peptide is, in milligrams per milliliter (mg/mL). More water makes it weaker; less water makes it stronger.
- Units (on the syringe)
- The marks on an insulin syringe. 100 units equals 1 mL. They measure how much liquid you draw, not the dose in milligrams.
- mcg and mg
- Units of dose. 1 milligram (mg) equals 1,000 micrograms (mcg).
- GLP-1
- A natural gut hormone that lowers appetite and blood sugar. Drugs that copy it, like semaglutide, are used for weight loss.
- Growth hormone secretagogue
- A compound that nudges your body to release more of its own growth hormone, rather than injecting the hormone itself.
- Half-life
- How long a compound stays active in your body. A longer half-life means you inject less often.
- Peptide vs small molecule
- A peptide is a short chain of amino acids. A few items here (like MK-677 or methylene blue) are small molecules, not true peptides, but people use them the same way.
- Research only
- No approved dose or use in people. Sold for research and not reviewed by the FDA for safety or quality.
- Investigational
- Still being tested in clinical trials and not yet approved or legally sold for general use.
- Banned in drug-tested sport
- Prohibited by the World Anti-Doping Agency (WADA); using it can disqualify a competing athlete.
Last reviewed 22 July 2026