Larazotide is a tight-junction regulator used for gut / leaky gut. Larazotide is an 8-amino-acid peptide that tightens the junctions between the cells lining your gut. In plain terms: it works locally in the intestine to seal a 'leaky' gut barrier and has been studied mainly for celiac disease. It is not absorbed into the body.

How much water do I add to Larazotide?

You can reconstitute Larazotide with 0.5, 1, or 2 mL of bacteriostatic water. Each option produces a different concentration and syringe draw for the same dose. Use the calculator to see which is easiest to measure.

What does Larazotide cost per dose?

Cost per dose depends on vial size, price paid, and your dose. Enter your vendor's price in the Larazotide calculator to see cost per dose and monthly cost.

What is the reference dose for Larazotide?

The commonly referenced range is 0.5 mg per dose, taken before meals. This is reference information, not a recommendation. Talk to a licensed clinician.

What are the side effects of Larazotide?

Reported side effects of Larazotide include: Well tolerated in trials.; It is not approved.. Severity and frequency vary by person and dose.

Who should not take Larazotide?

Larazotide is generally not appropriate for: No formal contraindications established. Talk to a licensed clinician before starting.

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Decoding

Larazotide_Dosage, benefits & legal status

Also known as AT-1001, larazotide acetate, INN-202

By the Peptide Decoding Editorial Team

Published July 22, 2026 · Updated July 25, 2026

An oral peptide studied for sealing a leaky gut, mainly in celiac disease.

Gut / leaky gutTight-junction regulatorInvestigational

InHealing and recoveryTaken without a needle

Dose0.5 mg per dose

FrequencyBefore meals

RouteBy mouth (oral)

StatusInvestigational

MixYour choice, calculate it

CycledNot cycled in the trials

Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.

What is Larazotide?

Plain language first. The technical label stays, but it never stands alone.

Overview

It works locally in the intestine to seal a 'leaky' gut barrier and has been studied mainly for celiac disease. It is not absorbed into the body.

The technical version

Larazotide is an 8-amino-acid peptide that tightens the junctions between the cells lining your gut.

What it's used for

An oral peptide studied for sealing a leaky gut lining, mainly for celiac disease. It works in the gut and is not absorbed.

How does Larazotide work?

What it does in the body, and where.

Larazotide is unusual here: it is designed specifically not to be absorbed. It works on the inside surface of your gut and never enters the bloodstream.

01
It tightens the junctions between gut lining cells
The seals between cells that determine what can pass from the gut into the body.
02
It works in the gut cavity, not in your blood
Which limits both its effects and its risks to the intestine itself.
03
Celiac disease is what it was built for
Reducing the symptoms that break through when someone eating gluten-free encounters small amounts anyway.
04
Phase 3 did not meet its endpoint
It has been through large trials, which is more than most compounds here can say, and it did not clearly work.

Where it acts

Gut

Where this compound is thought to act.

What else is it used for?

Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.

Celiac disease symptoms despite a gluten-free diet, where the Phase 3 trial was stopped in 2022 for lack of benefitInvestigational
Sealing a leaky gut lining generallyEarly research

The published record

Research index

Records indexed for Larazotide

63 in humans, 18 of them original studies.

31 registered trials, 12 with posted results.

Browse the records

In animalsPro

In the labPro

ReviewsPro

Senior author sharePro

Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 11 September 2026.

Compound field notes

At a glance

Four things to know about Larazotide

Evidence

Investigational

How much, and do you cycle it?

The range, and whether you take breaks.

0.5 mg per dose, before meals. Not cycled in the trialsTrial dose

In the trials this was given continuously for the whole study period. No on/off schedule has been tested, so there is nothing to report beyond that.

Compare this against the whole library →

How long does it stay in the body?

The half-life, and where the figure comes from.

Not the right questionNo figure

Larazotide is designed to work inside the gut and not be absorbed into the bloodstream at all, so a blood half-life does not describe what it does.

Source: Paterson BM, et al. Aliment Pharmacol Ther 2007;26:757-766

You can compare this against the whole library to see where it sits.

What does it cost?

Typical dose and cost, in plain numbers.

Larazotide is not injected

It is taken by mouth (oral).

Cost per month

—

Cost per dose

—

Typical dose

500 mcg–500 mcg / doseTrial dose

What it costs

Larazotide starts at $50.00 across 1 vendor.

2 listings, last read Sep 4, 2026. Shipping and card fees are not included.

See all 2 listings →

How do you store it?

Before mixing, and after.

Room temperature. Cool, dry, out of light.

Larazotide is taken as a pill or capsule. Keep it in its original container at room temperature, away from heat, humidity, and direct sun. No fridge or mixing needed. Check the expiration date on the bottle.

What are the side effects and cautions?

Known cautions and warnings for this compound.

Who should avoid it

Check these before anything else.

No formal contraindications established

Stop and get help

These are emergencies. Seek care.

Signs of an allergic reaction

Common effects

Expected, and usually mild.

Comparable to placebo in trials, since it works in the gut and is not absorbed
Its Phase 3 celiac trial was stopped in 2022 because it did not work well enough, not because it was unsafe

Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.

Is Larazotide approved?

And where the numbers on this page come from.

No. Larazotide is not approved anywhere and is currently in company-run clinical trials. There is no legal route to obtain it outside a trial.

Approval status
Investigational
Route
By mouth (oral)
Checked
September 2026

What has happened recently

We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.

You can compare this against the whole library, or read how to check a seller.

DoseFrom published clinical trials. Not approved by a regulator for this dose.
Vial sizeFrom what vendors typically list; not a recommendation.
Sources
Beyond Celiac, phase 3 study of larazotide acetate to treat celiac disease discontinued Beyond Celiac, phase 3 celiac disease drug trial halted
Reviewed8 September 2026

What else is like Larazotide?

Others in Healing and recovery, side by side.

If you're weighing Larazotide, it's worth reading Pentosan Polysulfate (PPS), Cerebrolysin, and Cortagen in the same class.

YOU ARE HERE

Larazotide

An oral peptide studied for sealing a leaky gut, mainly in celiac disease.

Investigational

Dose: 0.5 mg per dose
How often: Before meals

PPS

Pentosan Polysulfate (PPS)

A treatment for arthritis and painful bladder that acts like a joint lubricant.

Clinical use

Dose: 300 mg per day (100 mg three times a day)
How often: Weekly courses

CEREBRO

Cerebrolysin

An injectable brain-peptide blend used abroad for stroke and dementia recovery.

Clinical use

Dose: 10 up to 50 mL per day (start low, increase slowly)
How often: 10-20 day cycles

CORTA

Cortagen

A bioregulator taken in courses for nerve and tissue recovery, with thin evidence.

Research only

Dose: Varies (course-based)
How often: Courses

Browse recovery-focused compounds Browse every no-needle compound

Guides for this compound

How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.

Sources

Beyond Celiac, phase 3 study of larazotide acetate to treat celiac disease discontinued(2022)
The CeDLara phase 3 was stopped at interim analysis. The company reported that the group size needed to show a significant difference against placebo was too large to justify continuing.
Beyond Celiac, phase 3 celiac disease drug trial halted(2022)
Larazotide was the first celiac disease candidate to reach phase 3, more than 15 years after entering clinical trials. It did not finish. Full results were never reported.

Last reviewed 8 September 2026

Beyond these, 84 records are indexed. Browse the records