BPC-157 + TB-500_Dosage, benefits & legal status
Also known as Wolverine, Wolverine blend, Wolverine stack, Wolverine peptide, BPC-157 + TB-500, TB-500 + BPC-157, BPC/TB, TB/BPC
The two best-known healing peptides in one shot, at a ratio that changes by vendor.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is BPC-157 + TB-500?
Plain language first. The technical label stays, but it never stands alone.Overview
It puts the two most popular healing compounds into a single injection. The nickname Wolverine is a community name borrowed from the comic book character. No company owns it, and no two vendors have to agree on what goes in the vial.
BPC-157 + TB-500 is a pre-mixed blend of two repair peptides: BPC-157 and TB-500.
What it's used for
The best-known healing combination in one shot, taken for tendon, muscle, and gut repair after injury, surgery, or hard training.
How does BPC-157 + TB-500 work?
What it does in the body, and where.BPC-157 + TB-500 puts the two most popular repair peptides in one vial. Both are thought to work on healing, and they do it through different steps, which is the argument for pairing them. Neither has a controlled human trial.
- 01BPC-157 appears to promote new blood vessel growthMore blood supply to an injured area means more oxygen and more of the material repair requires.
- 02TB-500 appears to help cells move to where they are neededIt binds actin, part of the scaffolding a cell uses to change shape and travel, which is the step before a wound closes.
- 03The pairing is an assumption, not a findingNobody has tested whether two repair signals in one shot work better than one. The blend exists because both peptides are popular, not because a study compared them.
Where this compound is thought to act.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Healing tendons, ligaments, and muscle after injury or surgeryResearch only
- Gut repair, from the BPC-157 side of the blendResearch only
- Convenience, since it puts two peptides into one injectionResearch only
How much, and do you cycle it?
The range, and whether you take breaks.0.25 up to 0.5 mg BPC-157 per day (the TB-500 follows your ratio), varies. Commonly run in 4 to 8 week blocks around an injury, then stoppedCommunity practice
The block length is borrowed from how BPC-157 is usually run on its own, tied to how long a soft-tissue injury takes to settle. No human study has tested a duration for either peptide, and none has tested them together, so there is no evidence that a break is needed or that long-term use is safe.
How long does it stay in the body?
The half-life, and where the figure comes from.Neither part has a published human figureNo figure
BPC-157 and TB-500. BPC-157 has been measured in rats and never in people. TB-500 as sold is a short fragment, and the work everyone cites is on the full-length protein.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
No standard exists. Ratios run from 1:1 to 1:2, and totals from 10 mg to 60 mg. Some clinics skip the vial entirely and give the two as separate shots. Pick the option that matches your label, or enter your own.
Pick your vial to see concentrations and a draw.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
BPC-157 + TB-500 starts at $49.00 across 20 vendors, typically $3.50 – $4.90 per mg.
27 listings, last read Aug 27, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized BPC-157 + TB-500 keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.There is no standard BPC-157 + TB-500 ratio. Vials sold under the Wolverine nickname include 5 mg BPC-157 with 5 mg TB-500, 10 mg with 10 mg, 30 mg with 30 mg, and 5 mg BPC-157 with 10 mg TB-500. Some clinics skip the blend and give the two as separate shots. A dose you read online tells you nothing unless you also know which vial the writer had. Read your own label first, then use the calculator.
Who should avoid it
- Active cancer, as a precaution given that both peptides promote new blood-vessel growth
- Pregnancy or breastfeeding
- Banned in drug-tested sport. BPC-157 falls under WADA category S0 and TB-500 under S2.3, so each is prohibited on its own
Stop and get help
- Spreading hives, swelling of the face or throat, or trouble breathing, which is a medical emergency
- Redness, heat, or pus at the injection site, which can signal infection
- New lumps or masses
Common effects
- Injection-site reactions
- Generally well tolerated in the limited data that exists for each peptide alone
- Almost all evidence for both is from animals, so the human profile is not established
- This is a blend, so the cautions of both peptides apply at once. It is also harder to tell which one caused a reaction.
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is BPC-157 + TB-500 approved?
And where the numbers on this page come from.No. BPC-157 + TB-500 is not approved for any use, anywhere. It is sold labelled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin (subcutaneous)
- CheckedAugust 2026
What has happened recently
Both peptides in this blend were reviewed by an FDA advisory committee on July 23, 2026, and both were recommended for the list of substances pharmacies may compound. Each vote was 8 to 6 with one abstention, and the FDA's own scientific reviewers had advised against both. A recommendation is advice, not a decision. Compounding either peptide is still not legal today. The blend itself has never been reviewed as a product by anyone.
Banned in drug-tested sport. Most research peptides are prohibited under WADA's S0 category, which covers any substance with no approval from any regulatory authority for human use. That means a compound can be banned without ever being named on the prohibited list. Check with your own anti-doping authority rather than assuming absence from the list means permitted.
You can compare this against the whole library, or read how to check a seller.
- DoseFrom research and community reports. No regulator has reviewed this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
- Reviewed14 August 2026
What else is like BPC-157 + TB-500?
Others in Healing and recovery, side by side.If you're weighing BPC-157 + TB-500, it's worth reading Teduglutide (Gattex), Teriparatide (Forteo), and Livagen in the same class.
The two best-known healing peptides in one shot, at a ratio that changes by vendor.
- Dose
- 0.25 up to 0.5 mg BPC-157 per day (the TB-500 follows your ratio)
- How often
- Varies
The real GLP-2 drug, and nothing to do with weight loss.
- Dose
- 0.05 mg per kg of body weight per day
- How often
- Daily
The bone drug that builds new bone instead of just slowing the loss.
- Dose
- 20 mcg per day
- How often
- Daily
A lab-made 4 amino acid peptide aimed at the liver.
- Dose
- Research only
- How often
- Daily, in 10-20 day courses
10What these words mean
Show glossary +
What these words mean
- 503A and 503B
- The two kinds of compounding pharmacy in US law. A 503A pharmacy prepares medicine for one named patient. A 503B outsourcing facility makes larger batches under stricter manufacturing rules.
- Agonist
- Something that switches a receptor on. The opposite is an antagonist. It blocks the receptor instead.
- Amino acid
- The building blocks that link together in a chain to make a peptide or a protein. The order they sit in is what makes one peptide different from another.
- Amylin
- A hormone released alongside insulin that slows the stomach emptying and reduces appetite. Several weight loss compounds copy it.
- Analog
- A compound built to copy a natural one with small deliberate changes, usually so it lasts longer or holds onto its target more tightly.
- Animal study
- Research done in rats, mice or other animals. Most findings do not repeat in people, so an animal result is a reason to keep looking. It is not a reason to act.
- Antibody
- A large immune protein, far bigger than a peptide, engineered to lock onto one specific target. These are made by drug companies and are not sold as research powders.
- Bacteriostatic water
- Sterile water with a tiny amount of preservative, used to mix powdered peptides.
- Banned in drug-tested sport
- Prohibited by the World Anti-Doping Agency (WADA); using it can disqualify a competing athlete.
- Bioavailability
- How much of a dose actually reaches your bloodstream. Most peptides survive stomach acid badly, so most of them are injected instead of swallowed.
- Bioregulator
- Very short peptides from a Russian research tradition, usually two to four amino acids long, sold for supporting a specific organ. Human evidence is thin and most of it is published in Russian.
- Blend
- One vial holding more than one compound, mixed together by the seller. Working out a dose means working out each ingredient separately, because they are rarely present in equal amounts.
- Boxed warning
- The most serious warning the FDA puts on a drug label, printed inside a black border. It flags a risk considered severe enough to sit above everything else on the label.
- Bulks list
- The FDA's list of ingredients that compounding pharmacies are allowed to use. A substance can sit under review on it for years without anything being decided either way.
- Certificate of analysis (COA)
- A lab report on a batch of product. It only means something if it names the batch you actually received, comes from an independent lab, and can be checked with that lab.
- Clinical trial
- A study that gives a treatment to people under a written plan and measures what happens. It is the only kind of evidence that can show something works in humans.
- Compounding
- A licensed pharmacy preparing a medicine to order. Being allowed to compound something is not the same as the FDA approving it, and the two get mixed up constantly.
- Concentration
- How strong the mixed peptide is, in milligrams per milliliter (mg/mL). More water makes it weaker; less water makes it stronger.
- Cycle
- A stretch of time using a compound followed by a break. Most cycling patterns come from community practice. Very few have been tested.
- DAC
- Short for Drug Affinity Complex. An attachment added to a peptide so it grabs onto a blood protein and stays in the body for days instead of minutes.
- Dead space
- The small amount of liquid left sitting inside the needle and hub after you inject. On very small doses it can be a real share of what you meant to take.
- Dilute
- Adding more liquid to make a mix weaker. The amount of peptide in the vial does not change. It is just spread through more water, so each draw is bigger.
- Endpoint
- The result a trial said in advance that it would measure. A study can be reported as positive and still have missed the endpoint it set out to hit.
- FDA approved
- Reviewed by the FDA and cleared for a specific use, in a specific form, at a specific dose. Approval for one use is not approval for another, and approval in another country is not approval here.
- Fragment
- A short piece cut out of a larger natural protein. A fragment can behave very differently from the whole protein it came from, so evidence about one does not transfer to the other.
- Ghrelin
- The hunger hormone. Some growth hormone compounds work by copying it, so they can make you noticeably hungrier.
- GHRH
- A natural signal telling the pituitary gland to release growth hormone. Several compounds copy it.
- GHRP
- A second, separate signal that also triggers growth hormone release, through a different door than GHRH. This is why the two types are often used together.
- GLP-1
- A natural gut hormone that lowers appetite and blood sugar. Drugs that copy it, like semaglutide, are used for weight loss.
- Growth hormone secretagogue
- A compound that nudges your body to release more of its own growth hormone, rather than injecting the hormone itself.
- Half-life
- How long a compound stays active in your body. A longer half-life means you inject less often.
- HPLC
- A lab method that separates out everything in a sample so the amounts can be measured. It shows how much of the main ingredient is there. It does not confirm that the main ingredient is the right molecule.
- In vitro
- Done in a dish or a test tube, on cells outside a living body. It is the earliest kind of evidence there is.
- Injection site
- The spot on the body where you inject. Moving it around gives the skin and fat underneath time to recover between doses.
- Intramuscular (IM)
- An injection into a muscle, using a longer needle.
- Intravenous (IV)
- An injection into a vein. It needs training and equipment and is not something to do at home.
- Investigational
- Still being tested in clinical trials and not yet approved or legally sold for general use.
- Lyophilized
- Freeze-dried into a powder so it keeps longer. That is the white cake or dust in the bottom of an unmixed vial.
- Mass spectrometry
- A lab method that weighs molecules to confirm what they are. HPLC answers how much is in the sample. This answers what it is.
- mcg and mg
- Units of dose. 1 milligram (mg) equals 1,000 micrograms (mcg).
- Myostatin
- A natural brake on muscle growth. Several compounds are built to block it, though human results have been far smaller than the animal work suggested.
- Off-label
- A doctor prescribing an approved drug for something other than its approved use. This is legal and common, and it is different from a compound having no approval at all.
- Orphan drug designation
- A status given to treatments for rare conditions to make them worth developing. It is an incentive, not an approval, and a compound can hold it while being approved for nothing.
- PCAC
- The FDA advisory committee that reviews compounding ingredients. It recommends. It does not approve, and the FDA does not have to follow what it says.
- Peer review
- Other scientists checking a paper before a journal publishes it. It filters out some bad work. It does not make a finding true.
- Peptide vs small molecule
- A peptide is a short chain of amino acids. A few items here (like MK-677 or methylene blue) are small molecules, not true peptides, but people use them the same way.
- Placebo
- A dummy treatment given for comparison. Without one it is very hard to tell a real effect apart from expectation and time passing.
- Purity
- The share of a sample that is the intended compound, usually given as a percentage. A high purity number on the wrong molecule is still the wrong molecule.
- Randomized
- Deciding by chance who gets which treatment, so the two groups are comparable. Studies that skip this are much easier to read the wrong way.
- Receptor
- A docking point on a cell that a compound attaches to. If a cell has no matching receptor, the compound does nothing to it.
- Reconstitution
- Mixing a powdered peptide with liquid (bacteriostatic water) so it can be drawn into a syringe.
- Research only
- No approved dose or use in people. Sold for research and not reviewed by the FDA for safety or quality.
- Stack
- Using more than one compound at the same time. Almost no combinations have been tested together in people, so a stack is usually built on guesswork.
- Sterile water
- Water with nothing added to stop bacteria growing. It works for a single dose, but a vial mixed with it should not be kept and used again.
- Subcutaneous
- An injection just under the skin, into the fat layer, usually with a short, thin insulin needle.
- Titrate
- Starting at a low dose and increasing it slowly over time so your body adjusts and side effects stay mild.
- Trial phases
- The stages of human testing. Phase 1 checks safety in a small group, phase 2 looks for an effect, and phase 3 tests it against a comparison in a large group.
- Units (on the syringe)
- The marks on an insulin syringe. 100 units equals 1 mL. They measure how much liquid you draw, not the dose in milligrams.
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- Why Does My Peptide Injection Itch or Welt
Injection-site irritation, a histamine reaction, or a true allergy, and how to tell them apart.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
Sources
- FDA, Pharmacy Compounding Advisory Committee meeting, July 23-24, 2026(2026)Meeting page listing the bulk drug substances reviewed and the uses considered.
Last reviewed 14 August 2026
Peptide Decoding is published by Decoded Sciences LLC. We take no payment from vendors for coverage, inclusion or ranking, and our affiliate relationships are disclosed in full.