BPC-157 + TB-500_Dosage, benefits & legal status
Also known as Wolverine, Wolverine blend, Wolverine stack, Wolverine peptide, BPC-157 + TB-500, TB-500 + BPC-157, BPC/TB, TB/BPC
The two best-known healing peptides in one shot, at a ratio that changes by vendor.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is BPC-157 + TB-500?
Plain language first. The technical label stays, but it never stands alone.Overview
It puts the two most popular healing compounds into a single injection. The nickname Wolverine is a community name borrowed from the comic book character. No company owns it, and no two vendors have to agree on what goes in the vial.
BPC-157 + TB-500 is a pre-mixed blend of two repair peptides: BPC-157 and TB-500.
What it's used for
The best-known healing combination in one shot, taken for tendon, muscle, and gut repair after injury, surgery, or hard training.
How does BPC-157 + TB-500 work?
What it does in the body, and where.BPC-157 + TB-500 puts the two most popular repair peptides in one vial. Both are thought to work on healing, and they do it through different steps, which is the argument for pairing them. Neither has a controlled human trial.
- 01BPC-157 appears to promote new blood vessel growthMore blood supply to an injured area means more oxygen and more of the material repair requires.
- 02TB-500 appears to help cells move to where they are neededIt binds actin, part of the scaffolding a cell uses to change shape and travel, which is the step before a wound closes.
- 03The pairing is an assumption, not a findingNobody has tested whether two repair signals in one shot work better than one. The blend exists because both peptides are popular, not because a study compared them.
Where this compound is thought to act.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Healing tendons, ligaments, and muscle after injury or surgeryResearch only
- Gut repair, from the BPC-157 side of the blendResearch only
- Convenience, since it puts two peptides into one injectionResearch only
The published record
Papers and trials about BPC-157 + TB-500
39 papers tagged human · 29 not reviews or lab · 0 clinical trial publications
5 registered trials · 2 with posted results
Furthest stage reached: Registered study, no drug phase, results posted
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about BPC-157 + TB-500
Evidence
Category
Healing and recovery
Common vial
Varies
Half-life
Neither part has a published human figure
How much, and do you cycle it?
The range, and whether you take breaks.0.25 up to 0.5 mg BPC-157 per day (the TB-500 follows your ratio), varies. Commonly run in 4 to 8 week blocks around an injury, then stopped Community practice
The block length is borrowed from how BPC-157 is usually run on its own, tied to how long a soft-tissue injury takes to settle. No human study has tested a duration for either peptide, and none has tested them together, so there is no evidence that a break is needed or that long-term use is safe.
Neither part has a published human figureNo figure
BPC-157 and TB-500. BPC-157 has been measured in rats and never in people. TB-500 as sold is a short fragment, and the work everyone cites is on the full-length protein.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
No standard exists. Ratios run from 1:1 to 1:2, and totals from 10 mg to 60 mg. Some clinics skip the vial entirely and give the two as separate shots. Pick the option that matches your label, or enter your own.
Pick your vial to see concentrations and a draw.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
What one draw delivers
The same arithmetic as the calculator, worked out for the vials vendors sell.Dose anchored to BPC-157, at the 0.25 to 0.5 mg per day people commonly cite. Each table assumes one draw per day. If you split it across more injections, divide the reading by the number of injections.
| BPC-157 dose | 1 mL water | 2 mL water | 3 mL water |
|---|---|---|---|
| 0.25 mg | 5.0 units
| 10.0 units
| 15.0 units
|
| 0.5 mg | 10.0 units
| 20.0 units
| 30.0 units
|
| BPC-157 dose | 1 mL water | 2 mL water | 3 mL water |
|---|---|---|---|
| 0.25 mg | 2.5 units
| 5.0 units
| 7.5 units
|
| 0.5 mg | 5.0 units
| 10.0 units
| 15.0 units
|
| BPC-157 dose | 1 mL water | 2 mL water | 3 mL water |
|---|---|---|---|
| 0.25 mg | 0.8 units Too small to measure reliably.
| 1.7 units Too small to measure reliably.
| 2.5 units
|
| 0.5 mg | 1.7 units Too small to measure reliably.
| 3.3 units
| 5.0 units
|
| BPC-157 dose | 1 mL water | 2 mL water | 3 mL water |
|---|---|---|---|
| 0.25 mg | 5.0 units
| 10.0 units
| 15.0 units
|
| 0.5 mg | 10.0 units
| 20.0 units
| 30.0 units
|
No published human study establishes a dose for this blend. The range comes from vendor and community practice, and is anchored to one component because a blend is one draw: the other components follow at whatever ratio is in your vial.
Community protocols describe 500 to 1000 mcg of total blend per day, which on a 1:1 vial is 250 to 500 mcg of each peptide. Dosing at the top of that range puts TB-500 at about 3.5 mg per week, inside its own commonly cited 2 to 5 mg weekly range. Dosing at the bottom puts TB-500 at about 1.75 mg per week, under its own floor. A daily blend also spreads TB-500 across seven small doses, where it is usually given two or three times a week on its own.
BPC-157 + TB-500 starts at $33.60 across 53 vendors, typically $3.95 – $10.00 per mg.
73 listings, last read Oct 11, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized BPC-157 + TB-500 keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.There is no standard BPC-157 + TB-500 ratio. Vials sold under the Wolverine nickname include 5 mg BPC-157 with 5 mg TB-500, 10 mg with 10 mg, 30 mg with 30 mg, and 5 mg BPC-157 with 10 mg TB-500. Some clinics skip the blend and give the two as separate shots. A dose you read online tells you nothing unless you also know which vial the writer had. Read your own label first, then use the calculator.
Who should avoid it
- Active cancer, as a precaution given that both peptides promote new blood-vessel growth
- Pregnancy or breastfeeding
- Banned in drug-tested sport. BPC-157 falls under WADA category S0 and TB-500 under S2.3, so each is prohibited on its own
Stop and get help
- Spreading hives, swelling of the face or throat, or trouble breathing, which is a medical emergency
- Redness, heat, or pus at the injection site, which can signal infection
- New lumps or masses
Common effects
- Injection-site reactions
- Generally well tolerated in the limited data that exists for each peptide alone
- Almost all evidence for both is from animals, so the human profile is not established
- This is a blend, so the cautions of both peptides apply at once. It is also harder to tell which one caused a reaction.
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is BPC-157 + TB-500 approved?
And where the numbers on this page come from.No. BPC-157 + TB-500 is not approved for any use, anywhere. It is sold labeled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin (subcutaneous)
- Checked14 August 2026
- DoseFrom community reports. No regulator or trial established this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
What has happened recently
Both peptides in this blend were reviewed by an FDA advisory committee on July 23, 2026, and both were recommended for the list of substances pharmacies may compound. Each vote was 8 to 6 with one abstention, and the FDA's own scientific reviewers had advised against both. A recommendation is advice, not a decision. Compounding either peptide is still not legal today. The blend itself has never been reviewed as a product by anyone.
Banned in drug-tested sport. Most research peptides are prohibited under WADA's S0 category, which covers any substance with no approval from any regulatory authority for human use. That means a compound can be banned without ever being named on the prohibited list. Check with your own anti-doping authority rather than assuming absence from the list means permitted.
You can compare this against the whole library, or read how to check a seller.
What else is like BPC-157 + TB-500?
Others in Healing and recovery, side by side.If you're weighing BPC-157 + TB-500, it's worth reading ARA-290 (Cibinetide), VIP (Vasoactive Intestinal Peptide), and Cartalax in the same class.
The two best-known healing peptides in one shot, at a ratio that changes by vendor.
- Dose
- 0.25 up to 0.5 mg BPC-157 per day (the TB-500 follows your ratio)
- How often
- Varies
A peptide studied for calming nerve pain and inflammation.
- Dose
- 1 up to 4 mg per day (start low, increase slowly)
- How often
- Daily
A nasal-spray peptide used to calm chronic inflammation and immune problems.
- Dose
- 0.05 mg per dose
- How often
- Several daily
A bioregulator for cartilage and joint health, with thin evidence.
- Dose
- Varies (course-based)
- How often
- Courses
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- Why Does My Peptide Injection Itch or Welt
Injection-site irritation, a histamine reaction, or a true allergy, and how to tell them apart.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
Sources
- FDA, Pharmacy Compounding Advisory Committee meeting, July 23-24, 2026(2026)Meeting page listing the bulk drug substances reviewed and the uses considered.
Beyond these, 225 records are indexed. Browse the records