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Decoding

ARA-290 (Cibinetide)_

Also known as cibinetide, ARA290

A peptide studied for calming nerve pain and inflammation.

Nerve pain & healingEPO-derived peptideInvestigational
InHealing and recovery
Common vial size5 mg
Dose1 up to 4 mg per day (start low, increase slowly)
FrequencyDaily
RouteUnder the skin (subcutaneous)
StatusInvestigational
MixYour choice, calculate it
CycledA 28-day daily course is what has been studied

Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.

01

What is ARA-290 (Cibinetide)?

Plain language first. The technical label stays, but it never stands alone.

Overview

ARA-290 (cibinetide) is an 11-amino-acid peptide carved from the tissue-protective part of erythropoietin (EPO), the hormone that makes red blood cells. In plain terms: it keeps only EPO's healing, anti-inflammatory side, switching on a 'repair receptor' in injured nerves and tissue without thickening the blood. It reached real human trials for nerve pain.

What it's used for

A peptide studied for calming nerve pain and inflammation, especially in diabetic nerve damage, without affecting red blood cells.

02

How does ARA-290 (Cibinetide) work?

What it does in the body, and where.

ARA-290 is a fragment of erythropoietin with the blood-cell-making part removed, keeping only the tissue-protective side.

  1. 01
    It activates the innate repair receptor
    A different receptor from the one EPO uses to make red blood cells, which is why this fragment can be separated out.
  2. 02
    Inflammation calms and nerve tissue repairs
    The effect studied in small-fibre neuropathy and sarcoidosis.
  3. 03
    It does not raise red blood cells
    Which is the whole design goal. EPO's clotting risk comes from that effect, and removing it removes the risk.
  4. 04
    Human trials are small but real
    Unlike most of this category, it has completed placebo-controlled trials in people, with modest results.
Where it acts
Nerve

Where this compound is thought to act.

03

What else is it used for?

Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.

  • Nerve pain in sarcoidosis, which reached Phase 2 trialsInvestigational
  • Nerve damage from diabetesInvestigational
  • Inflammation and tissue repair generallyEarly research
04

How much, and do you cycle it?

The range, and whether you take breaks.

1 up to 4 mg per day (start low, increase slowly), daily. A 28-day daily course is what has been studiedTrial dose

The phase 2 trials in small-fibre neuropathy and type 2 diabetes ran daily injections for 28 days and stopped. That is the only duration with human data behind it. Nothing has been published on repeating the course or on how long to wait before doing so.

Source: ARA-290 in sarcoidosis small-fibre neuropathy, 28-day daily course (NCT02039687)

Compare cycling across compounds →

05

How do I dose and price it?

Enter your vial and your dose. Pick a mix. We show the draw and the cost.

The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.

Your vial size (mg)
Printed on the vial.
What you paid per vial
$
Used for cost per dose only.
Your dose (mg)
Commonly referenced range: 1 up to 4 mg per day (start low, increase slowly)Human study

Choose your mix

your own mL
units · —
Enter your own volume

Measuring the water1 mL = one full 100-unit syringe.

Your draw

40 / 100 units
Full calculator with reorder date →Read a syringe →
06

How do you store it?

Before mixing, and after.

Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.

Unmixed lyophilized ARA-290 (Cibinetide) keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.

07

What are the side effects and cautions?

Known cautions and warnings for this compound.

Who should avoid it

Check these before anything else.
  • No formal contraindications established in trials

Stop and get help

These are emergencies. Seek care.
  • Signs of an allergic reaction

Common effects

Expected, and usually mild.
  • Well tolerated across Phase 2 trials with no safety concerns identified
  • Unlike the hormone it is derived from, it does not thicken the blood

Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.

08

Is ARA-290 (Cibinetide) approved?

And where the numbers on this page come from.
Investigational

No. Not FDA-approved.

It is still being studied; a regulator has not cleared it for this use.

  • DoseFrom published clinical trials. Not approved by a regulator for this dose.
  • Vial sizeFrom what vendors typically list; not a recommendation.
  • Reviewed22 July 2026
09

What else is like ARA-290 (Cibinetide)?

Others in Healing and recovery, side by side.

If you're weighing ARA-290 (Cibinetide), it's worth reading PDA (Pentadeca Arginate), GLOW blend, and KLOW blend in the same class.

YOU ARE HERE
ARA-290 (Cibinetide)

A peptide studied for calming nerve pain and inflammation.

Investigational
Dose
1 up to 4 mg per day (start low, increase slowly)
How often
Daily
PDA (Pentadeca Arginate)

A newer, more stable cousin of BPC-157 for faster healing.

Research only
Dose
0.25 up to 0.5 mg per day (start low, increase slowly)
How often
1-2x daily
GLOWBlend
GLOW blend

A popular skin-and-healing blend of three peptides in one shot.

Research only
Dose
Per blend (mcg each)
How often
Daily
KLOWBlend
KLOW blend

The GLOW blend plus an anti-inflammatory peptide, an all-in-one recovery stack.

Research only
Dose
Per blend (mcg each)
How often
Daily
Browse recovery-focused compounds
10

What these words mean

Show glossary +
Titrate
Starting at a low dose and increasing it slowly over time so your body adjusts and side effects stay mild.
Subcutaneous
An injection just under the skin, into the fat layer, usually with a short, thin insulin needle.
Intramuscular (IM)
An injection into a muscle, using a longer needle.
Reconstitution
Mixing a powdered peptide with liquid (bacteriostatic water) so it can be drawn into a syringe.
Bacteriostatic water
Sterile water with a tiny amount of preservative, used to mix powdered peptides.
Concentration
How strong the mixed peptide is, in milligrams per milliliter (mg/mL). More water makes it weaker; less water makes it stronger.
Units (on the syringe)
The marks on an insulin syringe. 100 units equals 1 mL. They measure how much liquid you draw, not the dose in milligrams.
mcg and mg
Units of dose. 1 milligram (mg) equals 1,000 micrograms (mcg).
GLP-1
A natural gut hormone that lowers appetite and blood sugar. Drugs that copy it, like semaglutide, are used for weight loss.
Growth hormone secretagogue
A compound that nudges your body to release more of its own growth hormone, rather than injecting the hormone itself.
Half-life
How long a compound stays active in your body. A longer half-life means you inject less often.
Peptide vs small molecule
A peptide is a short chain of amino acids. A few items here (like MK-677 or methylene blue) are small molecules, not true peptides, but people use them the same way.
Research only
No approved dose or use in people. Sold for research and not reviewed by the FDA for safety or quality.
Investigational
Still being tested in clinical trials and not yet approved or legally sold for general use.
Banned in drug-tested sport
Prohibited by the World Anti-Doping Agency (WADA); using it can disqualify a competing athlete.

Last reviewed 22 July 2026