VIP (Vasoactive Intestinal Peptide)_Dosage, benefits & legal status
Also known as vasoactive intestinal peptide, aviptadil, VIP
A nasal-spray peptide used to calm chronic inflammation and immune problems.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is VIP (Vasoactive Intestinal Peptide)?
Plain language first. The technical label stays, but it never stands alone.Overview
It relaxes blood vessels and airways and calms the immune system. A nasal spray form is used to try to quiet chronic inflammation. It can also lower blood pressure.
VIP (vasoactive intestinal peptide) is a natural 28-amino-acid signaling peptide found in the gut, lungs, and nerves.
What it's used for
A nasal-spray peptide used to calm long-term inflammation and immune problems, popular in mold-illness protocols.
How does VIP (Vasoactive Intestinal Peptide) work?
What it does in the body, and where.VIP is a 28-amino-acid signaling peptide your gut, lungs, and nerves already produce. The nasal form is used off-label for chronic inflammatory conditions.
- 01It relaxes blood vessels and airwaysThe 'vasoactive' in the name, and its original identified function.
- 02It calms immune signalingShifting immune cells away from an inflammatory state, which is the basis for its use in chronic inflammatory response syndrome.
- 03The nasal route is deliberateVIP is destroyed almost immediately in the bloodstream, so it is sprayed rather than injected.
- 04Its main use is off-label and contestedThe mould-illness protocols it appears in are not accepted by mainstream medicine, and the peptide's evidence should not be confused with the protocol's.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Sarcoidosis and lung inflammationInvestigational
- Chronic inflammatory response syndrome and mold illness, which is the main reason people seek it outResearch only
- Severe COVID lung failure, where a large trial found no benefitInvestigational
The published record
Papers and trials about VIP (Vasoactive Intestinal Peptide)
Searched: vasoactive intestinal peptide administration, aviptadil, inhaled vasoactive intestinal peptide, vasoactive intestinal peptide therapy, VIP nasal spray.
Left out: VIP (too short to disambiguate without context); VIP (too short to disambiguate without context).
32 papers tagged human · 15 not reviews or lab · 5 clinical trial publications
9 registered trials · 3 with posted results
Furthest stage reached: Phase 3, results posted
Compare this against the whole library →
Category 1RegulatorsCounted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about VIP (Vasoactive Intestinal Peptide)
How much, and do you cycle it?
The range, and whether you take breaks.0.05 mg per dose, several daily. No established schedule No range
No published study has established how long to take this or whether a break is needed. Schedules quoted online come from vendors and forums, and different sources disagree.
About 1 minuteHuman study
One of the shortest in the library. A second study describes two phases, about 2 minutes and about 21 minutes.
Source: Domschke S, et al. Gut 1978, PMID 730072. Second human study, PMID 16435487
You can compare this against the whole library to see where it sits.
What does it cost?
Typical dose and cost, in plain numbers.The products priced here are not injected
Route: nasal spray.
VIP (Vasoactive Intestinal Peptide) starts at $25.00 across 87 vendors, typically $5.00 – $11.90 per mg.
104 listings, last read Oct 24, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Fridge after opening. Use within about 30 days.
Store sealed VIP (Vasoactive Intestinal Peptide) in the fridge. Once opened, keep it upright in the fridge and plan to finish it inside roughly 30 days. Keep it out of light and do not freeze the liquid.
What are the side effects and cautions?
Known cautions and warnings for this compound.Solubility, computed: 32% charged residues, 36% hydrophobic. Water usually sufficient.
A first-pass rule from peptide manufacturers' guidance. It does not account for disulfide bridges, salt form or how the powder was dried, and it predicts what should be easy rather than what will happen in your vial.
Who should avoid it
- Low blood pressure, since it widens blood vessels
- No formal contraindications established
Stop and get help
- Feeling faint or very dizzy, which can signal a blood-pressure drop
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Diarrhea
- A drop in blood pressure, which is the main known effect
- In a large COVID trial it was stopped for lack of benefit, not for safety problems
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is VIP (Vasoactive Intestinal Peptide) approved?
And where the numbers on this page come from.No. VIP (Vasoactive Intestinal Peptide) is not approved for any use, anywhere. It is sold labeled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteNasal spray
- Checked22 July 2026
- DoseFrom community reports. No regulator or trial established this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesNone traced yet.
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
What regulators say
From official documentsCategory 1
Listed as Vasoactive Intestinal Peptide
Checked 11 September 2026FDA: Bulk Drug Substances Nominated for Use in Compounding Under Section 503A (interim categories 1, 2, 3), updated May 14, 2026
You can compare this against the whole library, or read how to check a seller.
What else is like VIP (Vasoactive Intestinal Peptide)?
Others in Healing and recovery, side by side.If you're weighing VIP (Vasoactive Intestinal Peptide), it's worth reading Cartalax, Cortagen, and Livagen in the same class.
A nasal-spray peptide used to calm chronic inflammation and immune problems.
- Dose
- 0.05 mg per dose
- How often
- Several daily
A bioregulator for cartilage and joint health, with thin evidence.
- Dose
- Varies (course-based)
- How often
- Courses
A bioregulator taken in courses for nerve and tissue recovery, with thin evidence.
- Dose
- Varies (course-based)
- How often
- Courses
A lab-made 4 amino acid peptide aimed at the liver.
- Dose
- Research only
- How often
- Daily, in 10-20 day courses
Guides for this compound
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence
Beyond these, 73 records are indexed. Browse the records