VIP (Vasoactive Intestinal Peptide)_Dosage, benefits & legal status
Also known as vasoactive intestinal peptide, aviptadil, VIP
A nasal-spray peptide used to calm chronic inflammation and immune problems.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is VIP (Vasoactive Intestinal Peptide)?
Plain language first. The technical label stays, but it never stands alone.Overview
It relaxes blood vessels and airways and calms the immune system. A nasal spray form is used to try to quiet chronic inflammation. It can also lower blood pressure.
VIP (vasoactive intestinal peptide) is a natural 28-amino-acid signaling peptide found in the gut, lungs, and nerves.
What it's used for
A nasal-spray peptide used to calm long-term inflammation and immune problems, popular in mold-illness protocols.
How does VIP (Vasoactive Intestinal Peptide) work?
What it does in the body, and where.VIP is a 28-amino-acid signalling peptide your gut, lungs, and nerves already produce. The nasal form is used off-label for chronic inflammatory conditions.
- 01It relaxes blood vessels and airwaysThe 'vasoactive' in the name, and its original identified function.
- 02It calms immune signallingShifting immune cells away from an inflammatory state, which is the basis for its use in chronic inflammatory response syndrome.
- 03The nasal route is deliberateVIP is destroyed almost immediately in the bloodstream, so it is sprayed rather than injected.
- 04Its main use is off-label and contestedThe mould-illness protocols it appears in are not accepted by mainstream medicine, and the peptide's evidence should not be confused with the protocol's.
Where this compound is thought to act.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Sarcoidosis and lung inflammationInvestigational
- Chronic inflammatory response syndrome and mould illness, which is the main reason people seek it outResearch only
- Severe COVID lung failure, where a large trial found no benefitInvestigational
The published record
72
Records indexed for VIP (Vasoactive Intestinal Peptide)
32 in humans, 15 of them original studies.
9 registered trials, 3 with posted results.
FDA: Category 1.
Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 11 September 2026.
At a glance
Four things to know about VIP (Vasoactive Intestinal Peptide)
Evidence
Research only
Category
Healing and recovery
Common vial
5 mg
Half-life
About 1 minute
How much, and do you cycle it?
The range, and whether you take breaks.0.05 mg per dose, several daily. No established scheduleNo range
No published study has established how long to take this or whether a break is needed. Schedules quoted online come from vendors and forums, and different sources disagree.
How long does it stay in the body?
The half-life, and where the figure comes from.About 1 minuteHuman study
One of the shortest in the library. A second study describes two phases, about 2 minutes and about 21 minutes.
Source: Domschke S, et al. Gut 1978, PMID 730072. Second human study, PMID 16435487
You can compare this against the whole library to see where it sits.
What does it cost?
Typical dose and cost, in plain numbers.VIP (Vasoactive Intestinal Peptide) is not injected
It is taken nasal spray.
VIP (Vasoactive Intestinal Peptide) starts at $34.44 across 23 vendors, typically $5.80 – $17.40 per mg.
33 listings, last read Sep 6, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Fridge after opening. Use within about 30 days.
Store sealed VIP (Vasoactive Intestinal Peptide) in the fridge. Once opened, keep it upright in the fridge and plan to finish it inside roughly 30 days. Keep it out of light and do not freeze the liquid.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Low blood pressure, since it widens blood vessels
- No formal contraindications established
Stop and get help
- Feeling faint or very dizzy, which can signal a blood-pressure drop
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Diarrhea
- A drop in blood pressure, which is the main known effect
- In a large COVID trial it was stopped for lack of benefit, not for safety problems
What regulators say
- FDA: Bulk Drug Substances Nominated for Use in Compounding Under Section 503A (interim categories 1, 2, 3), updated May 14, 2026Category 1
Listed as Vasoactive Intestinal Peptide
Checked 11 September 2026
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is VIP (Vasoactive Intestinal Peptide) approved?
And where the numbers on this page come from.No. VIP (Vasoactive Intestinal Peptide) is not approved for any use, anywhere. It is sold labelled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteNasal spray
- CheckedSeptember 2026
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
You can compare this against the whole library, or read how to check a seller.
- DoseFrom research and community reports. No regulator has reviewed this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
- Reviewed8 September 2026
What else is like VIP (Vasoactive Intestinal Peptide)?
Others in Healing and recovery, side by side.If you're weighing VIP (Vasoactive Intestinal Peptide), it's worth reading Larazotide, Pentosan Polysulfate (PPS), and Cerebrolysin in the same class.
A nasal-spray peptide used to calm chronic inflammation and immune problems.
- Dose
- 0.05 mg per dose
- How often
- Several daily
An oral peptide studied for sealing a leaky gut, mainly in celiac disease.
- Dose
- 0.5 mg per dose
- How often
- Before meals
A treatment for arthritis and painful bladder that acts like a joint lubricant.
- Dose
- 300 mg per day (100 mg three times a day)
- How often
- Weekly courses
An injectable brain-peptide blend used abroad for stroke and dementia recovery.
- Dose
- 10 up to 50 mL per day (start low, increase slowly)
- How often
- 10-20 day cycles
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
- ClinicalTrials.gov NCT04360096, aviptadil study record(2020)Aviptadil is synthetic VIP. It holds FDA and EMA orphan drug designations for ARDS, and is approved in Scandinavia and several European countries for erectile dysfunction in combination with phentolamine. The ARDS phase 1 was eight patients.
- Inhaled aviptadil for possible treatment of COVID-19 in patients at high risk for ARDS, study protocol, Trials(2022)Records that daily doses up to 300 micrograms of inhaled aviptadil were shown safe in phase 2 trials for sarcoidosis and pulmonary hypertension. Every human route studied is intravenous or inhaled, not subcutaneous.
Last reviewed 8 September 2026
Beyond these, 72 records are indexed. Browse the records