KPV_
Also known as lysine-proline-valine
A tiny anti-inflammatory peptide for gut and skin, with no tanning effect.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is KPV?
Plain language first. The technical label stays, but it never stands alone.Overview
KPV is a tripeptide, the three-amino-acid tail (lysine-proline-valine) of the hormone alpha-MSH, minus the part that causes tanning. In plain terms: it carries alpha-MSH's anti-inflammatory action to calm the gut and skin without darkening skin. There are no human trials yet.
What it's used for
A tiny anti-inflammatory peptide people use to calm inflammation in the gut and skin, popular for IBD, colitis, and skin flare-ups.
How does KPV work?
What it does in the body, and where.KPV is three amino acids long: the tail end of alpha-MSH with the part that causes tanning removed. It keeps the anti-inflammatory action and loses the pigmentation.
- 01It gets inside the cellUnlike most peptides, which act on receptors at the cell surface, KPV appears to work from inside, which is why such a short chain does anything at all.
- 02It interrupts inflammatory signallingSpecifically the NF-kB pathway, one of the main switches that turns inflammation on.
- 03Used mainly for gut and skinThose are the tissues where the animal and cell evidence is strongest. Human trials are small and few.
Where this compound is thought to act.
What else is it used for?
Each group carries its own evidence level.Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
Gut inflammation
Early research- Animal studyIn mice, taking it by mouth reduced the severity of two different chemically induced colitis models, cutting both weight loss and inflammation.
- Animal studyIn one severe colitis model it rescued every treated mouse from death.
- Animal studyIt prevented colitis-associated cancer in mice, and the effect disappeared in mice lacking the transporter it uses, confirming the mechanism.
Delivery and mechanism
Research only- Animal studyA nanoparticle delivery form worked at a concentration 12,000 times lower than the plain peptide in mouse colitis.
- Lab studyIn cells it reduced a key inflammatory signalling step by up to 80%.
- No dataNo completed human trial has tested it, and the FDA has stated it lacks safety information on it in humans.
How much, and do you cycle it?
The range, and whether you take breaks.0.2 up to 0.5 mg per day (start low, increase slowly), daily, 4-8 wk courses. Taken in daily, 4-8 wk coursesCommunity practice
Course dosing is how this one is normally used. Where the course length comes from is the thing to check: for most compounds in this pattern it is convention rather than a tested schedule.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
4 / 100 unitsHow do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized KPV keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- No controlled human trials exist, so no contraindications are established
- Pregnancy
Stop and get help
- Signs of an allergic reaction
- Anything unusual, given the absence of human data
Common effects
- Unknown in humans. Anti-inflammatory effects have only been shown in cells and animals
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is KPV approved?
And where the numbers on this page come from.No. Not FDA-approved.
Sold for research use only. Not cleared for human consumption or medical use.
- DoseFrom research and community reports. No regulator has reviewed this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
- Reviewed22 July 2026
What else is like KPV?
Others in Healing and recovery, side by side.If you're weighing KPV, it's worth reading PDA (Pentadeca Arginate), GLOW blend, and KLOW blend in the same class.
A tiny anti-inflammatory peptide for gut and skin, with no tanning effect.
- Dose
- 0.2 up to 0.5 mg per day (start low, increase slowly)
- How often
- Daily, 4-8 wk courses
A newer, more stable cousin of BPC-157 for faster healing.
- Dose
- 0.25 up to 0.5 mg per day (start low, increase slowly)
- How often
- 1-2x daily
A popular skin-and-healing blend of three peptides in one shot.
- Dose
- Per blend (mcg each)
- How often
- Daily
The GLOW blend plus an anti-inflammatory peptide, an all-in-one recovery stack.
- Dose
- Per blend (mcg each)
- How often
- Daily
10What these words mean
Show glossary +
What these words mean
- Titrate
- Starting at a low dose and increasing it slowly over time so your body adjusts and side effects stay mild.
- Subcutaneous
- An injection just under the skin, into the fat layer, usually with a short, thin insulin needle.
- Intramuscular (IM)
- An injection into a muscle, using a longer needle.
- Reconstitution
- Mixing a powdered peptide with liquid (bacteriostatic water) so it can be drawn into a syringe.
- Bacteriostatic water
- Sterile water with a tiny amount of preservative, used to mix powdered peptides.
- Concentration
- How strong the mixed peptide is, in milligrams per milliliter (mg/mL). More water makes it weaker; less water makes it stronger.
- Units (on the syringe)
- The marks on an insulin syringe. 100 units equals 1 mL. They measure how much liquid you draw, not the dose in milligrams.
- mcg and mg
- Units of dose. 1 milligram (mg) equals 1,000 micrograms (mcg).
- GLP-1
- A natural gut hormone that lowers appetite and blood sugar. Drugs that copy it, like semaglutide, are used for weight loss.
- Growth hormone secretagogue
- A compound that nudges your body to release more of its own growth hormone, rather than injecting the hormone itself.
- Half-life
- How long a compound stays active in your body. A longer half-life means you inject less often.
- Peptide vs small molecule
- A peptide is a short chain of amino acids. A few items here (like MK-677 or methylene blue) are small molecules, not true peptides, but people use them the same way.
- Research only
- No approved dose or use in people. Sold for research and not reviewed by the FDA for safety or quality.
- Investigational
- Still being tested in clinical trials and not yet approved or legally sold for general use.
- Banned in drug-tested sport
- Prohibited by the World Anti-Doping Agency (WADA); using it can disqualify a competing athlete.