KPV_Dosage, benefits & legal status
Also known as lysine-proline-valine
A tiny anti-inflammatory peptide for gut and skin, with no tanning effect.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is KPV?
Plain language first. The technical label stays, but it never stands alone.Overview
It carries alpha-MSH's anti-inflammatory action to calm the gut and skin without darkening skin. There are no human trials yet.
KPV is a tripeptide, the three-amino-acid tail (lysine-proline-valine) of the hormone alpha-MSH, minus the part that causes tanning.
What it's used for
A tiny anti-inflammatory peptide people use to calm inflammation in the gut and skin, popular for IBD, colitis, and skin flare-ups.
How does KPV work?
What it does in the body, and where.KPV is three amino acids long: the tail end of alpha-MSH with the part that causes tanning removed. It keeps the anti-inflammatory action and loses the pigmentation.
- 01It gets inside the cellUnlike most peptides, which act on receptors at the cell surface, KPV appears to work from inside, which is why such a short chain does anything at all.
- 02It interrupts inflammatory signalingSpecifically the NF-kB pathway, one of the main switches that turns inflammation on.
- 03Used mainly for gut and skinThose are the tissues where the animal and cell evidence is strongest. None of it has been tested in a person.
What else is it used for?
Each group carries its own evidence level.Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
Gut inflammation
Early research- Animal studyIn mice, taking it by mouth reduced the severity of two different chemically induced colitis models, cutting both weight loss and inflammation.
- Animal studyIn one severe colitis model it rescued every treated mouse from death.
- Animal studyIt prevented colitis-associated cancer in mice, and the effect disappeared in mice lacking the transporter it uses, confirming the mechanism.
Delivery and mechanism
Research only- Animal studyA nanoparticle delivery form worked at a concentration 12,000 times lower than the plain peptide in mouse colitis.
- Lab studyIn cells it reduced a key inflammatory signaling step by up to 80%.
- No dataNo completed human trial has tested it, and the FDA has stated it lacks safety information on it in humans.
The published record
Papers and trials about KPV
Searched: KPV, Lys-Pro-Val, KPV tripeptide.
Left out: KPV (too short to disambiguate without context).
50 papers tagged human · 32 not reviews or lab · 0 clinical trial publications
Furthest stage reached: No clinical trial on record
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Uses evaluated: wound healing and inflammatory conditionsRegulatorsCounted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about KPV
How much, and do you cycle it?
The range, and whether you take breaks.0.2 up to 0.5 mg per day (start low, increase slowly), daily, 4-8 wk courses. Taken in daily, 4-8 wk courses Community practice
Course dosing is how this one is normally used. Where the course length comes from is the thing to check: for most compounds in this pattern it is convention rather than a tested schedule.
Nothing publishedNo figure
Nothing published. KPV is a three amino acid fragment of a larger hormone and no study has measured how long it lasts.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
KPV starts at $20.00 across 162 vendors, typically $3.28 – $8.00 per mg.
266 listings, last read Oct 24, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized KPV keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- No controlled human trials exist, so no contraindications are established
- Pregnancy
Stop and get help
- Signs of an allergic reaction
- Anything unusual, given the absence of human data
Common effects
- Unknown in humans. Anti-inflammatory effects have only been shown in cells and animals
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is KPV approved?
And where the numbers on this page come from.No. KPV is not approved for any use, anywhere. It is sold labeled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteBy mouth, under the skin, or on the skin
- Checked9 October 2026
- DoseFrom community reports. No regulator or trial established this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
What has happened recently
Not eligible for compounding under Section 503A: no monograph, not a component of an approved drug, not on the Bulks List. Previously in Category 2; the nomination was withdrawn. An FDA advisory committee recommended inclusion on July 23-24, 2026; that recommendation is non-binding and no rule has taken effect. The use the FDA evaluated: Wound healing and inflammatory conditions. Evaluation is not approval; if listed, the listed use would define what a pharmacy could compound it for. The FDA’s safety page states that it has identified no human exposure data on drug products containing this substance administered via any route of administration.
What regulators say
From official documentsFDA staff proposed not adding to the 503A bulks list
Free base named in the proposal read at source
Checked 22 September 2026FDA: FDA Briefing Document, Pharmacy Compounding Advisory Committee meeting of July 23 to 24, 2026: introduction and FDA proposalsConsidered at the July 23, 2026 session
Checked 22 September 2026FDA: July 23 to 24, 2026 meeting of the Pharmacy Compounding Advisory Committee: meeting materialsNominated but withdrawn; previously category 2
FDA has not identified any human exposure data for any route
Checked 11 September 2026FDA: Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks (category 2 and withdrawn nominations), current as of April 22, 2026Uses evaluated: wound healing and inflammatory conditions
Checked 22 September 2026FDA: Federal Register notice of April 16, 2026: Pharmacy Compounding Advisory Committee meeting, bulk drug substances nominated for the 503A list
You can compare this against the whole library, or read how to check a seller.
Common questions
Has KPV been tested in humans?
Not as a treatment. No completed clinical trial has given KPV to people, and the FDA has said it lacks safety information on KPV in humans.
What exists is work in human cells and in animals. The research index on this page counts 50 papers tagged human, and that tag lands on reviews, commentary and laboratory work using human tissue just as readily as on trials. None of them are clinical trial publications.
So KPV's anti-inflammatory effects have been shown in a dish and in mice. What happens when a person takes it is unknown.
What else is like KPV?
Others in Healing and recovery, side by side.If you're weighing KPV, it's worth reading BPC-157 + TB-500, GLOW blend, and KLOW blend in the same class.
A tiny anti-inflammatory peptide for gut and skin, with no tanning effect.
- Dose
- 0.2 up to 0.5 mg per day (start low, increase slowly)
- How often
- Daily, 4-8 wk courses
The two best-known healing peptides in one shot, at a ratio that changes by vendor.
- Dose
- 0.25 up to 0.5 mg BPC-157 per day (the TB-500 follows your ratio)
- How often
- Varies
A popular skin-and-healing blend of three peptides in one shot.
- Dose
- Community examples use 2 to 2.5 mg of total blend per day, or set the draw by GHK-Cu.
- How often
- Daily
The GLOW blend plus an anti-inflammatory peptide, an all-in-one recovery stack.
- Dose
- Community examples use 2 to 4 mg of total blend per day, or set the draw by GHK-Cu.
- How often
- Daily
Also sold in a blend: KLOW blend, Coremend blend (TB-500 / BPC-157 / KPV)
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
- FDA, bulk substances that may present significant safety risks(2026)FDA states that it has identified no human exposure data by any route for this substance.
- KPV and PepT1 colitis study, Gastroenterology, 2008
- FDA, Pharmacy Compounding Advisory Committee meeting, July 23-24, 2026(2026)FDA meeting page listing the bulk drug substances reviewed and the uses considered.
Beyond these, 211 records are indexed. Browse the records