Coremend blend (TB-500 / BPC-157 / KPV)_Dosage, benefits & legal status
Also known as Coremend, TB-500 + BPC-157 + KPV, BPC-157 + TB-500 + KPV, KPV + BPC-157 + TB-500
A named healing triple that is the Wolverine blend with KPV added.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Coremend blend (TB-500 / BPC-157 / KPV)?
Plain language first. The technical label stays, but it never stands alone.Overview
The Wolverine blend with KPV added. The TB-500 share is two and a half times the others, so a dose worked out for a 1:1 vial gives you far more TB-500 than you expect.
A research-market three-peptide co-formulation supplied as TB-500 25 mg, BPC-157 10 mg and KPV 10 mg in a 45 mg vial, sold under the product name Coremend. Compositionally it is the BPC-157 plus TB-500 pairing with the alpha-MSH fragment KPV added, and it differs from the KLOW blend by the absence of GHK-Cu. No published trial has evaluated the combination.
What it's used for
An injected three-peptide blend sold for tissue repair, recovery and inflammation.
How does Coremend blend (TB-500 / BPC-157 / KPV) work?
What it does in the body, and where.Coremend sits between two blends this library already covers, and the interesting part is the ratio rather than the ingredients.
- 01It is Wolverine plus KPVBPC-157 and TB-500 are the two most-sold healing peptides. KPV is a three-amino-acid fragment of alpha-MSH marketed for inflammation. Add GHK-Cu and you have KLOW.
- 02The ratio is uneven, and that mattersTB-500 sits at 25 mg against 10 mg each for the others. Every other blend in this family is close to 1:1, so a dose worked out from a Wolverine vial does not carry over.
- 03The evidence does not improve by stackingBPC-157 has no completed published randomized efficacy trial. TB-500 is a short fragment rather than the full thymosin beta-4 protein whose trials are usually quoted for it. KPV's work is mostly in animal models of colitis. Three thin evidence bases in one vial remain three thin evidence bases.
Where this compound is thought to act.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Tissue and tendon repair, from the BPC-157 and TB-500 halvesResearch only
- Gut inflammation, which is KPV's own claimResearch only
- Recovery after injury, which is what the blend is marketed fornone
How much, and do you cycle it?
The range, and whether you take breaks.Research only, varies. Not established for the blendNo range
No schedule has been studied for this combination. The components have different clearance times and different conventional frequencies, so a single shared schedule is a convenience of the vial rather than a finding.
How long does it stay in the body?
The half-life, and where the figure comes from.None of the three has a published human figureNo figure
BPC-157 has a rodent figure only. KPV has nothing published. The half-life quoted for TB-500 usually belongs to full-length thymosin beta-4, which is a different molecule. A blend has no single half-life. Each component clears on its own schedule, so one draw starts two or more different clocks. See each component's page.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
The published configuration is TB-500 25 mg, BPC-157 10 mg and KPV 10 mg in a 45 mg vial. Note the ratio is not 1:1: TB-500 is present at two and a half times the others, which is unusual in this family and changes what a single draw delivers. Coremend is one vendor's product name, so another seller's three-peptide healing vial may hold different amounts under a different name.
Pick your vial to see concentrations and a draw.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
Coremend blend (TB-500 / BPC-157 / KPV) starts at $229.00 across 1 vendor.
1 listing, last read Aug 22, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Coremend blend (TB-500 / BPC-157 / KPV) keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Pregnancy or breastfeeding
- Active cancer, as a precaution with anything that promotes tissue or blood-vessel growth
- Anyone competing in drug-tested sport, because TB-500 is named on the WADA prohibited list
- Anyone who wants established safety data, because none exists for this combination in humans
Stop and get help
- Signs of an allergic reaction, including spreading hives, facial or throat swelling, or trouble breathing
- Redness, heat, or pus at the injection site, which can signal infection
- Any new lump or unexplained symptom
Common effects
- Redness, soreness, or a small bump at the injection site
- Beyond that, unknown. No study has recorded what this combination commonly causes
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Coremend blend (TB-500 / BPC-157 / KPV) approved?
And where the numbers on this page come from.No. Coremend blend (TB-500 / BPC-157 / KPV) is not approved for any use, anywhere. It is sold labelled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin (subcutaneous)
- CheckedAugust 2026
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
Banned in drug-tested sport. Most research peptides are prohibited under WADA's S0 category, which covers any substance with no approval from any regulatory authority for human use. That means a compound can be banned without ever being named on the prohibited list. Check with your own anti-doping authority rather than assuming absence from the list means permitted.
You can compare this against the whole library, or read how to check a seller.
- DoseFrom research and community reports. No regulator has reviewed this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Reviewed24 August 2026
What else is like Coremend blend (TB-500 / BPC-157 / KPV)?
Others in Healing and recovery, side by side.If you're weighing Coremend blend (TB-500 / BPC-157 / KPV), it's worth reading Thymosin Beta-15, Abaloparatide (Tymlos), and Calcitonin (salmon) in the same class.
A named healing triple that is the Wolverine blend with KPV added.
- Dose
- Research only
- How often
- Varies
A thymosin the research literature knows as a cancer marker, not a repair peptide.
- Dose
- Research only
- How often
- Not established
A bone-building drug that completes the family around teriparatide.
- Dose
- Set by the label
- How often
- Once daily
A bone hormone borrowed from salmon, and the weakest option in its own category.
- Dose
- Set by the label
- How often
- Daily, by spray or injection
10What these words mean
Show glossary +
What these words mean
- 503A and 503B
- The two kinds of compounding pharmacy in US law. A 503A pharmacy prepares medicine for one named patient. A 503B outsourcing facility makes larger batches under stricter manufacturing rules.
- Agonist
- Something that switches a receptor on. The opposite is an antagonist. It blocks the receptor instead.
- Amino acid
- The building blocks that link together in a chain to make a peptide or a protein. The order they sit in is what makes one peptide different from another.
- Amylin
- A hormone released alongside insulin that slows the stomach emptying and reduces appetite. Several weight loss compounds copy it.
- Analog
- A compound built to copy a natural one with small deliberate changes, usually so it lasts longer or holds onto its target more tightly.
- Animal study
- Research done in rats, mice or other animals. Most findings do not repeat in people, so an animal result is a reason to keep looking. It is not a reason to act.
- Antibody
- A large immune protein, far bigger than a peptide, engineered to lock onto one specific target. These are made by drug companies and are not sold as research powders.
- Bacteriostatic water
- Sterile water with a tiny amount of preservative, used to mix powdered peptides.
- Banned in drug-tested sport
- Prohibited by the World Anti-Doping Agency (WADA); using it can disqualify a competing athlete.
- Bioavailability
- How much of a dose actually reaches your bloodstream. Most peptides survive stomach acid badly, so most of them are injected instead of swallowed.
- Bioregulator
- Very short peptides from a Russian research tradition, usually two to four amino acids long, sold for supporting a specific organ. Human evidence is thin and most of it is published in Russian.
- Blend
- One vial holding more than one compound, mixed together by the seller. Working out a dose means working out each ingredient separately, because they are rarely present in equal amounts.
- Boxed warning
- The most serious warning the FDA puts on a drug label, printed inside a black border. It flags a risk considered severe enough to sit above everything else on the label.
- Bulks list
- The FDA's list of ingredients that compounding pharmacies are allowed to use. A substance can sit under review on it for years without anything being decided either way.
- Certificate of analysis (COA)
- A lab report on a batch of product. It only means something if it names the batch you actually received, comes from an independent lab, and can be checked with that lab.
- Clinical trial
- A study that gives a treatment to people under a written plan and measures what happens. It is the only kind of evidence that can show something works in humans.
- Compounding
- A licensed pharmacy preparing a medicine to order. Being allowed to compound something is not the same as the FDA approving it, and the two get mixed up constantly.
- Concentration
- How strong the mixed peptide is, in milligrams per milliliter (mg/mL). More water makes it weaker; less water makes it stronger.
- Cycle
- A stretch of time using a compound followed by a break. Most cycling patterns come from community practice. Very few have been tested.
- DAC
- Short for Drug Affinity Complex. An attachment added to a peptide so it grabs onto a blood protein and stays in the body for days instead of minutes.
- Dead space
- The small amount of liquid left sitting inside the needle and hub after you inject. On very small doses it can be a real share of what you meant to take.
- Dilute
- Adding more liquid to make a mix weaker. The amount of peptide in the vial does not change. It is just spread through more water, so each draw is bigger.
- Endpoint
- The result a trial said in advance that it would measure. A study can be reported as positive and still have missed the endpoint it set out to hit.
- FDA approved
- Reviewed by the FDA and cleared for a specific use, in a specific form, at a specific dose. Approval for one use is not approval for another, and approval in another country is not approval here.
- Fragment
- A short piece cut out of a larger natural protein. A fragment can behave very differently from the whole protein it came from, so evidence about one does not transfer to the other.
- Ghrelin
- The hunger hormone. Some growth hormone compounds work by copying it, so they can make you noticeably hungrier.
- GHRH
- A natural signal telling the pituitary gland to release growth hormone. Several compounds copy it.
- GHRP
- A second, separate signal that also triggers growth hormone release, through a different door than GHRH. This is why the two types are often used together.
- GLP-1
- A natural gut hormone that lowers appetite and blood sugar. Drugs that copy it, like semaglutide, are used for weight loss.
- Growth hormone secretagogue
- A compound that nudges your body to release more of its own growth hormone, rather than injecting the hormone itself.
- Half-life
- How long a compound stays active in your body. A longer half-life means you inject less often.
- HPLC
- A lab method that separates out everything in a sample so the amounts can be measured. It shows how much of the main ingredient is there. It does not confirm that the main ingredient is the right molecule.
- In vitro
- Done in a dish or a test tube, on cells outside a living body. It is the earliest kind of evidence there is.
- Injection site
- The spot on the body where you inject. Moving it around gives the skin and fat underneath time to recover between doses.
- Intramuscular (IM)
- An injection into a muscle, using a longer needle.
- Intravenous (IV)
- An injection into a vein. It needs training and equipment and is not something to do at home.
- Investigational
- Still being tested in clinical trials and not yet approved or legally sold for general use.
- Lyophilized
- Freeze-dried into a powder so it keeps longer. That is the white cake or dust in the bottom of an unmixed vial.
- Mass spectrometry
- A lab method that weighs molecules to confirm what they are. HPLC answers how much is in the sample. This answers what it is.
- mcg and mg
- Units of dose. 1 milligram (mg) equals 1,000 micrograms (mcg).
- Myostatin
- A natural brake on muscle growth. Several compounds are built to block it, though human results have been far smaller than the animal work suggested.
- Off-label
- A doctor prescribing an approved drug for something other than its approved use. This is legal and common, and it is different from a compound having no approval at all.
- Orphan drug designation
- A status given to treatments for rare conditions to make them worth developing. It is an incentive, not an approval, and a compound can hold it while being approved for nothing.
- PCAC
- The FDA advisory committee that reviews compounding ingredients. It recommends. It does not approve, and the FDA does not have to follow what it says.
- Peer review
- Other scientists checking a paper before a journal publishes it. It filters out some bad work. It does not make a finding true.
- Peptide vs small molecule
- A peptide is a short chain of amino acids. A few items here (like MK-677 or methylene blue) are small molecules, not true peptides, but people use them the same way.
- Placebo
- A dummy treatment given for comparison. Without one it is very hard to tell a real effect apart from expectation and time passing.
- Purity
- The share of a sample that is the intended compound, usually given as a percentage. A high purity number on the wrong molecule is still the wrong molecule.
- Randomized
- Deciding by chance who gets which treatment, so the two groups are comparable. Studies that skip this are much easier to read the wrong way.
- Receptor
- A docking point on a cell that a compound attaches to. If a cell has no matching receptor, the compound does nothing to it.
- Reconstitution
- Mixing a powdered peptide with liquid (bacteriostatic water) so it can be drawn into a syringe.
- Research only
- No approved dose or use in people. Sold for research and not reviewed by the FDA for safety or quality.
- Stack
- Using more than one compound at the same time. Almost no combinations have been tested together in people, so a stack is usually built on guesswork.
- Sterile water
- Water with nothing added to stop bacteria growing. It works for a single dose, but a vial mixed with it should not be kept and used again.
- Subcutaneous
- An injection just under the skin, into the fat layer, usually with a short, thin insulin needle.
- Titrate
- Starting at a low dose and increasing it slowly over time so your body adjusts and side effects stay mild.
- Trial phases
- The stages of human testing. Phase 1 checks safety in a small group, phase 2 looks for an effect, and phase 3 tests it against a comparison in a large group.
- Units (on the syringe)
- The marks on an insulin syringe. 100 units equals 1 mL. They measure how much liquid you draw, not the dose in milligrams.
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Last reviewed 24 August 2026
Peptide Decoding is published by Decoded Sciences LLC. We take no payment from vendors for coverage, inclusion or ranking, and our affiliate relationships are disclosed in full.