GB-115_Dosage, benefits & legal status
Also known as GB115, dilept-related dipeptide, Zakusov GB-115
A Russian anti-anxiety dipeptide that blocks a panic receptor instead of sedating you.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is GB-115?
Plain language first. The technical label stays, but it never stands alone.Overview
It blocks the receptor that triggers panic, rather than damping the brain down the way a sedative does.
GB-115 is a synthetic dipeptide, N-(6-phenylhexanoyl)-glycyl-L-tryptophan amide, built as a retro-analogue of cholecystokinin-4 and acting as an antagonist at cholecystokinin receptors.
What it's used for
An experimental Russian anti-anxiety compound. A few vendors sell it. One human study backs it.
How does GB-115 work?
What it does in the body, and where.Most anxiety drugs damp the brain down. This one interferes with a specific panic signal.
- 01Cholecystokinin-4 provokes anxiety and panicIt is used in research precisely because injecting it reliably triggers panic in people. That makes its receptor an obvious target.
- 02GB-115 was reverse-engineered from that tetrapeptideThe designers built dipeptide analogs of CCK-4 and found that the L-tryptophan versions reduced anxiety while the D-tryptophan versions increased it.
- 03It blocks CCK receptors rather than activating GABASo the mechanism does not overlap with benzodiazepines or with phenibut, and in principle it should not sedate or produce dependence the same way.
- 04In principle is doing a lot of work in that sentenceThe theory is clean. One 21-day study in 31 people is not enough to know whether it holds in practice.
Hits 2 receptors at once.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Generalised anxiety disorderInvestigational
- Anxiety without the sedation of a benzodiazepineEarly research
- Focus and cognitive performance, as soldResearch only
The published record
Papers and trials about GB-115
6 papers tagged human · 3 not reviews or lab · 0 clinical trial publications
2 registered trials · none with posted results
Furthest stage reached: Phase 4 as registered, under way
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about GB-115
Evidence
Category
Brain, mood and sleep
Common vial
Varies
Half-life
No verified published figure
How much, and do you cycle it?
The range, and whether you take breaks.1 mg per day in the published human study, daily in the study. 21 days in the one human study Trial dose
The published study ran 21 days of continuous dosing. Nothing addresses longer use, breaks, or what happens on stopping.
No verified published figureNo figure
Short peptides of this kind clear quickly, and the group behind GB-115 has published on extrapolating short-peptide half-lives from animals to humans. We have not verified a figure for this compound, so none is shown.
You can compare this against the whole library to see where it sits.
What does it cost?
Typical dose and cost, in plain numbers.GB-115 is not injected
It is taken by mouth (oral). The published human study used 1 mg tablets in 31 patients with generalised anxiety disorder for 21 days, and its stated purpose was to work out an effective dose. Higher figures quoted on vendor sites do not come from that study.
How do you store it?
Before mixing, and after.Room temperature. Cool, dry, out of light.
GB-115 is taken as a pill or capsule. Keep it in its original container at room temperature, away from heat, humidity, and direct sun. No fridge or mixing needed. Check the expiration date on the bottle.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Pregnancy and breastfeeding
- Any existing anxiety disorder being treated with prescribed medication, without medical advice
- Children, who have not been studied
Stop and get help
- Worsening anxiety, panic or low mood
- Any new or unexplained symptom that starts after beginning it
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Reported as well tolerated in the small human study
- The side effect profile is not characterized outside that study
- Nothing is known about effects beyond three weeks
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is GB-115 approved?
And where the numbers on this page come from.No. GB-115 is not approved for any use, anywhere. It is sold labeled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteBy mouth (oral)
- Checked24 August 2026
- DoseFrom published clinical trials. Not approved by a regulator for this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
What has happened recently
Not approved in the US and, as far as the published record shows, not approved in Russia either. It came out of the Zakusov Institute of Pharmacology in Moscow, where a related program also produced Noopept. The human evidence is a single study in 31 patients with generalised anxiety disorder, using 1 mg tablets for 21 days, whose stated aim was to determine an effective dose and assess safety and tolerability. Vendor listings describing a completed phase 3 program are not supported by anything we could locate.
You can compare this against the whole library, or read how to check a seller.
What else is like GB-115?
Others in Brain, mood and sleep, side by side.If you're weighing GB-115, it's worth reading P7C3, Phenibut, and Trofinetide (Daybue) in the same class.
A Russian anti-anxiety dipeptide that blocks a panic receptor instead of sedating you.
- Dose
- 1 mg per day in the published human study
- How often
- Daily in the study
A neuroprotective molecule from a mouse screen. Never given to a person.
- Dose
- Research only
- How often
- No established pattern
A Russian anxiety drug sold as a nootropic. Stopping it suddenly can be dangerous.
- Dose
- No safe self-directed dose is established
- How often
- Not daily, if at all
An approved oral treatment for Rett syndrome, built from the first three amino acids of IGF-1 with one methyl group added.
- Dose
- 5,000 to 12,000 mg twice daily by weight (label)
- How often
- Twice daily
Guides for this compound
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
- Clinical study of GB-115 in generalised anxiety disorder, PubMed(2019)31 patients with GAD, 1 mg tablets, 21 days, to determine effective dose, safety and tolerability.
- Kolik et al., anxiolytic activity of dipeptide GB-115 after oral administration, PubMed(2013)Animal anxiolytic activity and the dependence of the effect on stress-response phenotype.
- Kolik et al., role of the cholecystokinin system in GB-115 activity, PubMed(2012)GB-115 prevented CCK-4-induced anxiety; activating CCK-2 abolished its effect.
Beyond these, 28 records are indexed. Browse the records