DNSP-11_Dosage, benefits & legal status
Also known as DNSP 11, dopamine neuron stimulating peptide-11, brain excitatory peptide
A brain peptide from the GDNF precursor, studied in rats and monkeys and never in people.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is DNSP-11?
Plain language first. The technical label stays, but it never stands alone.Overview
It is a small fragment of the precursor to a brain growth factor. It protected dopamine neurons in rats and monkeys. Nobody has given it to a person in a published study.
What it's used for
Sold for brain and nerve research. The published work is in cells, rats and monkeys, with nothing in people.
How does DNSP-11 work?
What it does in the body, and where.DNSP-11 came out of an attempt to get GDNF's benefits in a smaller molecule.
- 01GDNF protects dopamine neuronsBut it is a large protein that distributes poorly in the brain, which is why trials of it have struggled.
- 02This 11-mer is cut from GDNF's precursorIt supported neuron survival in culture and raised dopamine levels in rat brain for up to 28 days after a single injection into the substantia nigra.
- 03The delivery problem did not go awayWork in rats and monkeys used intranasal delivery or direct brain infusion. Its short half-life makes useful brain exposure from a systemic injection unlikely.
A schematic of the compound's mechanism, not a diagnostic image.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Protecting dopamine neurons, the cells lost in Parkinson's diseaseResearch only
- General brain and nerve repair claimsResearch only
The published record
Papers about DNSP-11
Searched: DNSP-11, dopamine neuron stimulating peptide-11, dopamine neuron stimulating peptide 11.
2 papers tagged human · 1 not reviews or lab · 0 clinical trial publications
Furthest stage reached: No clinical trial on record
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count. A preprint and its journal version count once.
At a glance
Four things to know about DNSP-11
Evidence
Category
Brain, mood and sleep
Common vial
10 mg
Half-life
Nothing published in humans
How much, and do you cycle it?
The range, and whether you take breaks.Research only, no established pattern. No established pattern No range
No published human study establishes a schedule.
How long does it stay in the body?
The half-life, and where the figure comes from.Nothing published in humansNo figure
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
No flat reference range is recorded for this compound. The calculator only does the math on the dose you enter.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
DNSP-11 starts at $37.99 across 2 vendors.
2 listings, last read Nov 7, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized DNSP-11 keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Vendor pages describing DNSP-11 as a proSAAS fragment are wrong. The published sequence comes from the GDNF precursor.
Solubility, computed: 45% charged residues, 55% hydrophobic. Water usually sufficient.
A first-pass rule from peptide manufacturers' guidance. It does not account for disulfide bridges, salt form or how the powder was dried, and it predicts what should be easy rather than what will happen in your vial.
Who should avoid it
- No human safety data exists at all
- Pregnancy
Stop and get help
- Anything unusual, since there is no known safety profile
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Unknown in humans. Studied only in cells, rats and monkeys
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is DNSP-11 approved?
And where the numbers on this page come from.No. DNSP-11 is not approved for any use, anywhere. It is sold labeled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteInjected in research; delivered into the brain or up the nose in the studies
- Checked24 September 2026
- DoseNo dose has been established in people.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
What has happened recently
Not approved anywhere. No registered human trial.
You can compare this against the whole library, or read how to check a seller.
What else is like DNSP-11?
Others in Brain, mood and sleep, side by side.If you're weighing DNSP-11, it's worth reading Cortexin, Davunetide (NAP), and MIF-1 in the same class.
A brain peptide from the GDNF precursor, studied in rats and monkeys and never in people.
- Dose
- Research only
- How often
- No established pattern
A brain extract from cattle, injected into muscle, used widely in Russia.
- Dose
- 10 mg per day
- How often
- Daily, in 10-day courses
An eight amino acid brain peptide that reached large human trials and failed the main one.
- Dose
- 30 mg per dose
- How often
- Twice daily, given as a nasal spray in the trial
A three amino acid brain peptide tested in Parkinson's and depression in the 1970s.
- Dose
- Research only
- How often
- No established pattern
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- Why Does My Peptide Injection Itch or Welt
Injection-site irritation, a histamine reaction, or a true allergy, and how to tell them apart.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
Sources
- Bradley LH, et al. Dopamine neuron stimulating actions of a GDNF propeptide. PLoS ONE(2010)A single injection into rat substantia nigra raised dopamine and its metabolites for up to 28 days.
- Stenslik MJ, et al. Repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease. J Neurosci Methods(2015)Intranasal dosing raised dopamine turnover in rats; brain exposure from systemic dosing is considered unlikely.
Beyond these, 6 records are indexed. Browse the records