DNSP-11 is a neurotrophic peptide fragment used for brain & nerves. DNSP-11 is an 11-amino-acid piece cut from the precursor of GDNF, a growth factor that supports dopamine neurons. In plain terms: researchers wanted GDNF's protective effect on dopamine cells in a molecule small enough to deliver, and this fragment is what they tested.

How much water do I add to DNSP-11?

You can reconstitute DNSP-11 with 0.5, 1, or 2 mL of bacteriostatic water. Each option produces a different concentration and syringe draw for the same dose. Use the calculator to see which is easiest to measure.

What does DNSP-11 cost per dose?

Cost per dose depends on vial size, price paid, and your dose. Enter your vendor's price in the DNSP-11 calculator to see cost per dose and monthly cost.

What is the reference dose for DNSP-11?

The commonly referenced range is Research only, taken no established pattern. This is reference information, not a recommendation. Talk to a licensed clinician.

What are the side effects of DNSP-11?

Reported side effects of DNSP-11 include: No human data of any kind exists.; The published work used delivery straight into the brain or into the nose, not an injection under the skin.. Severity and frequency vary by person and dose.

Who should not take DNSP-11?

DNSP-11 is generally not appropriate for: No human safety data exists at all; Pregnancy. Talk to a licensed clinician before starting.

Do you cycle DNSP-11?

No established pattern No published human study establishes a schedule.

New?New to peptides?Start here →

Decoding

DNSP-11_Dosage, benefits & legal status

Also known as DNSP 11, dopamine neuron stimulating peptide-11, brain excitatory peptide

By the Peptide Decoding Editorial Team

Published September 24, 2026

A brain peptide from the GDNF precursor, studied in rats and monkeys and never in people.

Brain & nervesNeurotrophic peptide fragmentResearch only

InBrain, mood and sleep

Common vial size5 mg

DoseResearch only

FrequencyNo established pattern

RouteInjected in research; delivered into the brain or up the nose in the studies

StatusResearch only

MixYour choice, calculate it

CycledNo established pattern

Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.

See how this dose compares across the library →

What is DNSP-11?

Plain language first. The technical label stays, but it never stands alone.

Overview

It is a small fragment of the precursor to a brain growth factor. It protected dopamine neurons in rats and monkeys. Nobody has given it to a person in a published study.

The technical version

DNSP-11 (PPEAPAEDRSL-NH2) is an amidated 11-mer from the proGDNF domain, neurotrophic to dopaminergic neurons in vitro and in rodent models of Parkinson's disease, acting through pathways that do not appear to involve the GFR-alpha1 receptor.

What it's used for

Sold for brain and nerve research. The published work is in cells, rats and monkeys, with nothing in people.

How does DNSP-11 work?

What it does in the body, and where.

DNSP-11 came out of an attempt to get GDNF's benefits in a smaller molecule.

01
GDNF protects dopamine neurons
But it is a large protein that distributes poorly in the brain, which is why trials of it have struggled.
02
This 11-mer is cut from GDNF's precursor
It supported neuron survival in culture and raised dopamine levels in rat brain for up to 28 days after a single injection into the substantia nigra.
03
The delivery problem did not go away
Work in rats and monkeys used intranasal delivery or direct brain infusion. Its short half-life makes useful brain exposure from a systemic injection unlikely.

Pathway

A schematic of the compound's mechanism, not a diagnostic image.

What else is it used for?

Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.

Protecting dopamine neurons, the cells lost in Parkinson's diseaseResearch only
General brain and nerve repair claimsResearch only

Compound field notes

At a glance

Four things to know about DNSP-11

Evidence

Research only

How much, and do you cycle it?

The range, and whether you take breaks.

Research only, no established pattern. No established patternNo range

No published human study establishes a schedule.

Compare this against the whole library →

How long does it stay in the body?

The half-life, and where the figure comes from.

Nothing published in humansNo figure

You can compare this against the whole library to see where it sits.

How do I dose and price it?

Enter your vial and your dose. Pick a mix. We show the draw and the cost.

The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.

Your vial size (mg)

Printed on the vial.

What you paid per vial

Used for cost per dose only.

Your dose (mg)

Commonly referenced range: Research onlyNo range

Choose your mix

0.5 mL water—units · 20 mg/mL

Half a 100-unit syringe

1 mL water—units · 10 mg/mL

One full 100-unit syringe

2 mL water—units · 5 mg/mL

Two full 100-unit syringes

your own mL

units · —

Enter your own volume

Measuring the water1 mL = one full 100-unit syringe.

Your draw

0 / 100 units

Full calculator with reorder date →Read a syringe →

What it costs

DNSP-11 starts at $37.99 across 1 vendor.

1 listing, last read Sep 12, 2026. Shipping and card fees are not included.

See all 1 listings →

How do you store it?

Before mixing, and after.

Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.

Unmixed lyophilized DNSP-11 keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.

What are the side effects and cautions?

Known cautions and warnings for this compound.

Handling note

Vendor pages describing DNSP-11 as a proSAAS fragment are wrong. The published sequence comes from the GDNF precursor.

Who should avoid it

Check these before anything else.

No human safety data exists at all
Pregnancy

Stop and get help

These are emergencies. Seek care.

Anything unusual, since there is no known safety profile
Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing

Common effects

Expected, and usually mild.

Unknown in humans. Studied only in cells, rats and monkeys

Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.

Is DNSP-11 approved?

And where the numbers on this page come from.

No. DNSP-11 is not approved for any use, anywhere. It is sold labelled for laboratory research only, and there is no legal route to buy it for human use.

Approval status
Research only
Route
Injected in research; delivered into the brain or up the nose in the studies
Checked
24 September 2026
Dose
From research and community reports. No regulator has reviewed this dose.
Vial size
From what vendors typically list; not a recommendation.
Sources
Bradley LH, et al. Dopamine neuron stimulating actions of a GDNF propeptide. PLoS ONE Stenslik MJ, et al. Repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease. J Neurosci Methods

What has happened recently

Not approved anywhere. No registered human trial.

You can compare this against the whole library, or read how to check a seller.

What else is like DNSP-11?

Others in Brain, mood and sleep, side by side.

If you're weighing DNSP-11, it's worth reading MIF-1, P7C3, and Semax in the same class.

YOU ARE HERE

DNSP-11

A brain peptide from the GDNF precursor, studied in rats and monkeys and never in people.

Research only

Dose: Research only
How often: No established pattern

MIF1

MIF-1

A three amino acid brain peptide tested in Parkinson's and depression in the 1970s.

Research only

Dose: Research only
How often: No established pattern

P7C3

A neuroprotective molecule from a mouse screen. Never given to a person.

Research only

Dose: Research only
How often: No established pattern

SEMAX

Semax

A peptide used for sharper focus, memory, and mental clarity.

Research only

Dose: 0.2 up to 0.6 mg per day
How often: 1-2x daily

Compare nootropic peptides

Guides for this compound

How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
Why Does My Peptide Injection Itch or Welt
Injection-site irritation, a histamine reaction, or a true allergy, and how to tell them apart.
How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.

Sources

Bradley LH, et al. Dopamine neuron stimulating actions of a GDNF propeptide. PLoS ONE(2010)
A single injection into rat substantia nigra raised dopamine and its metabolites for up to 28 days.
Stenslik MJ, et al. Repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease. J Neurosci Methods(2015)
Intranasal dosing raised dopamine turnover in rats; brain exposure from systemic dosing is considered unlikely.

Last reviewed 24 September 2026