Kisspeptin_
Also known as kisspeptin-10, metastin, KP-10
A peptide that switches on natural sex-hormone signaling for libido and fertility.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Kisspeptin?
Plain language first. The technical label stays, but it never stands alone.Overview
Kisspeptin is a natural brain peptide that sits at the very top of the reproductive hormone chain, switching on the neurons that release GnRH. In plain terms: it kick-starts your body's own sex-hormone production, which is why it is studied for libido and fertility, with a gentler feel than PT-141.
What it's used for
A peptide that switches on the body's natural sex-hormone signaling, studied for libido, fertility, and hormone support, with a gentler feel than PT-141.
How does Kisspeptin work?
What it does in the body, and where.Kisspeptin sits at the very top of the reproductive hormone chain. Everything downstream depends on it, which is why a fault in it causes puberty not to start.
- 01It switches on the neurons that release GnRHOne step above the hormone that everything else in this category acts on.
- 02Your own hormone cascade followsGnRH prompts LH and FSH, which prompt testosterone or oestrogen. Nothing is supplied from outside.
- 03Working upstream preserves the feedback loopsWhich is the argument for it over supplying hormones directly, though it also means it cannot exceed what your own system will produce.
- 04Human research is real but earlyIt has been studied in fertility clinics as an alternative trigger, and in brain imaging work on arousal.
Where this compound is thought to act.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Libido and sexual responseInvestigational
- Fertility treatment, where it has been used to trigger egg releaseInvestigational
- Kick-starting the body's own sex-hormone productionInvestigational
How much, and do you cycle it?
The range, and whether you take breaks.Varies (research), as studied. Should not be given continuously. Response fades within about two weeks of twice-daily dosingHuman study
This one has real tolerance data and it points the opposite way from most peptides here. Twice-daily dosing in women caused the response to collapse inside two weeks, with luteinising hormone falling from 23.3 to 1.1 by day 14. Twice-weekly dosing held up far better. The pituitary itself stayed responsive, so the fade happens upstream in the hypothalamus.
Source: Jayasena et al., tachyphylaxis to twice-daily kisspeptin-54 (reviewed in Hum Reprod Update 2014)
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
40 / 100 unitsHow do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Kisspeptin keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- No formal contraindications established
Stop and get help
- Signs of an allergic reaction
Common effects
- Very well tolerated, with side effects no more common than placebo
- Mild injection-site reactions
- Occasional brief flushing or headache
- Given to more than a thousand people in studies without observed harm
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Kisspeptin approved?
And where the numbers on this page come from.No. Not FDA-approved.
Sold for research use only. Not cleared for human consumption or medical use.
- DoseFrom research and community reports. No regulator has reviewed this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Reviewed22 July 2026
What else is like Kisspeptin?
Others in Sexual and hormonal, side by side.If you're weighing Kisspeptin, it's worth reading PT-141 (Bremelanotide), Gonadorelin (GnRH), and HCG (Human Chorionic Gonadotropin) in the same class.
A peptide that switches on natural sex-hormone signaling for libido and fertility.
- Dose
- Varies (research)
- How often
- As studied
An approved shot that boosts sexual desire through the brain.
- Dose
- 1.75 mg per dose
- How often
- As needed, before activity
A shot that keeps your own testosterone and fertility hormones going.
- Dose
- 0.1 up to 0.2 mg per dose (start low, increase slowly)
- How often
- 2-3x per week or more
A hormone shot that keeps the testicles making testosterone and sperm.
- Dose
- 250 up to 500 IU per dose (alongside testosterone therapy)
- How often
- 2-3x per week
10What these words mean
Show glossary +
What these words mean
- Titrate
- Starting at a low dose and increasing it slowly over time so your body adjusts and side effects stay mild.
- Subcutaneous
- An injection just under the skin, into the fat layer, usually with a short, thin insulin needle.
- Intramuscular (IM)
- An injection into a muscle, using a longer needle.
- Reconstitution
- Mixing a powdered peptide with liquid (bacteriostatic water) so it can be drawn into a syringe.
- Bacteriostatic water
- Sterile water with a tiny amount of preservative, used to mix powdered peptides.
- Concentration
- How strong the mixed peptide is, in milligrams per milliliter (mg/mL). More water makes it weaker; less water makes it stronger.
- Units (on the syringe)
- The marks on an insulin syringe. 100 units equals 1 mL. They measure how much liquid you draw, not the dose in milligrams.
- mcg and mg
- Units of dose. 1 milligram (mg) equals 1,000 micrograms (mcg).
- GLP-1
- A natural gut hormone that lowers appetite and blood sugar. Drugs that copy it, like semaglutide, are used for weight loss.
- Growth hormone secretagogue
- A compound that nudges your body to release more of its own growth hormone, rather than injecting the hormone itself.
- Half-life
- How long a compound stays active in your body. A longer half-life means you inject less often.
- Peptide vs small molecule
- A peptide is a short chain of amino acids. A few items here (like MK-677 or methylene blue) are small molecules, not true peptides, but people use them the same way.
- Research only
- No approved dose or use in people. Sold for research and not reviewed by the FDA for safety or quality.
- Investigational
- Still being tested in clinical trials and not yet approved or legally sold for general use.
- Banned in drug-tested sport
- Prohibited by the World Anti-Doping Agency (WADA); using it can disqualify a competing athlete.
Last reviewed 22 July 2026