How much water do I add to Kisspeptin?

You can reconstitute Kisspeptin with 0.5, 1, or 2 mL of bacteriostatic water. Each option produces a different concentration and syringe draw for the same dose. Use the calculator to see which is easiest to measure.

What does Kisspeptin cost per dose?

Cost per dose depends on vial size, price paid, and your dose. Enter your vendor's price in the Kisspeptin calculator to see cost per dose and monthly cost.

What is the reference dose for Kisspeptin?

The commonly referenced range is Varies (research), taken as studied. This is reference information, not a recommendation. Talk to a licensed clinician.

What are the side effects of Kisspeptin?

Reported side effects of Kisspeptin include: Generally well tolerated in trials, but data is limited.. Severity and frequency vary by person and dose.

Who should not take Kisspeptin?

Kisspeptin is generally not appropriate for: No formal contraindications established. Talk to a licensed clinician before starting.

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Decoding

Kisspeptin_Dosage, benefits & legal status

Also known as kisspeptin-10, metastin, KP-10

By the Peptide Decoding Editorial Team

Published July 22, 2026 · Updated July 25, 2026

A peptide that switches on natural sex-hormone signaling for libido and fertility.

Libido & fertilityGnRH-upstream peptideResearch only

InSexual and hormonal

Common vial size5 mg

DoseVaries (research)

FrequencyAs studied

RouteUnder the skin (subcutaneous)

StatusResearch only

MixYour choice, calculate it

CycledShould not be given continuously. Response fades within about two weeks of twice-daily dosing

Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.

What is Kisspeptin?

Plain language first. The technical label stays, but it never stands alone.

Overview

It kick-starts your body's own sex-hormone production. That is why it is studied for libido and fertility. It has a gentler feel than PT-141.

The technical version

Kisspeptin is a natural brain peptide that sits at the very top of the reproductive hormone chain, switching on the neurons that release GnRH.

What it's used for

A peptide that switches on the body's natural sex-hormone signaling, studied for libido, fertility, and hormone support, with a gentler feel than PT-141.

How does Kisspeptin work?

What it does in the body, and where.

Kisspeptin sits at the very top of the reproductive hormone chain. Everything downstream depends on it, which is why a fault in it causes puberty not to start.

01
It switches on the neurons that release GnRH
One step above the hormone that everything else in this category acts on.
02
Your own hormone cascade follows
GnRH prompts LH and FSH, which prompt testosterone or oestrogen. Nothing is supplied from outside.
03
Working upstream preserves the feedback loops
Which is the argument for it over supplying hormones directly, though it also means it cannot exceed what your own system will produce.
04
Human research is real but early
It has been studied in fertility clinics as an alternative trigger, and in brain imaging work on arousal.

Where it acts

BrainPituitary

Where this compound is thought to act.

What else is it used for?

Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.

Libido and sexual responseInvestigational
Fertility treatment, where it has been used to trigger egg releaseInvestigational
Kick-starting the body's own sex-hormone productionInvestigational

The published record

Research index

488

Records indexed for Kisspeptin400 papers and 21 trials indexed in detail.

171 in humans, 117 of them original studies.

21 registered trials, 6 with posted results.

FDA: Category 2 · FDA: In category 2 (503A).

Browse the records

In animalsPro

In the labPro

ReviewsPro

Senior author sharePro

Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 11 September 2026.

Compound field notes

At a glance

Four things to know about Kisspeptin

Evidence

Research only

How much, and do you cycle it?

The range, and whether you take breaks.

Varies (research), as studied. Should not be given continuously. Response fades within about two weeks of twice-daily dosingHuman study

This one has real tolerance data and it points the opposite way from most peptides here. Twice-daily dosing in women caused the response to collapse inside two weeks, with luteinising hormone falling from 23.3 to 1.1 by day 14. Twice-weekly dosing held up far better. The pituitary itself stayed responsive, so the fade happens upstream in the hypothalamus.

Source: Jayasena et al., tachyphylaxis to twice-daily kisspeptin-54 (reviewed in Hum Reprod Update 2014)

Compare this against the whole library →

How long does it stay in the body?

The half-life, and where the figure comes from.

4 minutes or 28 minutes, depending on the versionHuman study

Kisspeptin-10 clears in about 4 minutes and kisspeptin-54 in about 28 minutes. They are sold under the same name and are not interchangeable.

Source: https://www.jci.org/articles/view/139681

You can compare this against the whole library to see where it sits.

How do I dose and price it?

Enter your vial and your dose. Pick a mix. We show the draw and the cost.

The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.

Your vial size (mg)

Printed on the vial.

What you paid per vial

Used for cost per dose only.

Your dose (mg)

Commonly referenced range: Varies (research)No range

Choose your mix

0.5 mL water—units · 10 mg/mL

Half a 100-unit syringe

1 mL water—units · 5 mg/mL

One full 100-unit syringe

2 mL water—units · 2.5 mg/mL

Two full 100-unit syringes

your own mL

units · —

Enter your own volume

Measuring the water1 mL = one full 100-unit syringe.

Your draw

0 / 100 units

Full calculator with reorder date →Read a syringe →

What it costs

Kisspeptin starts at $19.00 across 40 vendors, typically $4.00 – $13.80 per mg.

61 listings, last read Sep 6, 2026. Shipping and card fees are not included.

See all 61 listings →

How do you store it?

Before mixing, and after.

Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.

Unmixed lyophilized Kisspeptin keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.

What are the side effects and cautions?

Known cautions and warnings for this compound.

Who should avoid it

Check these before anything else.

No formal contraindications established

Stop and get help

These are emergencies. Seek care.

Signs of an allergic reaction

Common effects

Expected, and usually mild.

Very well tolerated, with side effects no more common than placebo
Mild injection-site reactions
Occasional brief flushing or headache
Given to more than a thousand people in studies without observed harm

What regulators say

FDA: Bulk Drug Substances Nominated for Use in Compounding Under Section 503A (interim categories 1, 2, 3), updated May 14, 2026
Category 2
Listed as Kisspeptin-10; added September 29, 2023
Checked 11 September 2026
FDA: Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks (category 2 and withdrawn nominations), current as of April 22, 2026
In category 2 (503A)
Added September 29, 2023. Immunogenicity risk and no or limited safety information
Checked 11 September 2026

Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.

Is Kisspeptin approved?

And where the numbers on this page come from.

No. Kisspeptin is not approved for any use, anywhere. It is sold labelled for laboratory research only, and there is no legal route to buy it for human use.

Approval status
Research only
Route
Under the skin (subcutaneous)
Checked
September 2026

What has happened recently

We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.

You can compare this against the whole library, or read how to check a seller.

DoseFrom research and community reports. No regulator has reviewed this dose.
Vial sizeFrom what vendors typically list; not a recommendation.
Sources
Phase 2 randomized trial, second dose of kisspeptin-54 for oocyte maturation, Human Reproduction Phase 2 dose-ranging trial, kisspeptin-54 as an IVF trigger Kisspeptin receptor agonist for female reproductive disorders, Journal of Clinical Investigation Kisspeptin-54 triggers egg maturation in women undergoing IVF, Journal of Clinical Investigation
Reviewed8 September 2026

What else is like Kisspeptin?

Others in Sexual and hormonal, side by side.

If you're weighing Kisspeptin, it's worth reading Gonadorelin (GnRH), HCG (Human Chorionic Gonadotropin), and HMG (Menotropin) in the same class.

YOU ARE HERE

Kisspeptin

A peptide that switches on natural sex-hormone signaling for libido and fertility.

Research only

Dose: Varies (research)
How often: As studied

GNRH

Gonadorelin (GnRH)

A shot that keeps your own testosterone and fertility hormones going.

Clinical use

Dose: 0.1 up to 0.2 mg per dose (start low, increase slowly)
How often: 2-3x per week or more

HCG

HCG (Human Chorionic Gonadotropin)

A hormone shot that keeps the testicles making testosterone and sperm.

Clinical use

Dose: 250 up to 500 IU per dose (alongside testosterone therapy)
How often: 2-3x per week

HMG

HMG (Menotropin)

A fertility hormone shot that drives sperm or egg production.

Clinical use

Dose: 75 up to 150 IU per dose (start low, increase slowly)
How often: Several per week

Browse the hormonal peptide lineup

Compared with

PT-141 vs Kisspeptin

Both are sold for sex. One works on desire and is FDA approved, the other works on hormones and stops working within two weeks.

Read comparison →

Guides for this compound

How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.

Sources

Phase 2 randomized trial, second dose of kisspeptin-54 for oocyte maturation, Human Reproduction(2017)
62 women at high risk of ovarian hyperstimulation syndrome, randomized 1:1. A second dose of kisspeptin-54 at 10 hours improved oocyte yield.
Phase 2 dose-ranging trial, kisspeptin-54 as an IVF trigger(2015)
60 women, open-label randomized, adaptive dose allocation from 3.2 to 12.8 nmol/kg. Oocyte maturation and OHSS rates measured.
Kisspeptin receptor agonist for female reproductive disorders, Journal of Clinical Investigation(2020)
Kisspeptin-54 has a terminal half-life of 27.6 minutes. Kisspeptin-10 has a terminal half-life of 4 minutes. They are different molecules sold under one name.
Kisspeptin-54 triggers egg maturation in women undergoing IVF, Journal of Clinical Investigation(2014)
Dose-finding trial. At the two lowest doses egg collection was substantially harder than with a standard hCG trigger, so the protocol moved to higher doses.

Last reviewed 8 September 2026

Beyond these, 421 records are indexed. Browse the records