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Decoding

Ipamorelin + CJC-1295 blend_

Also known as CJC/Ipa, CJC-1295 and Ipamorelin

The popular growth-hormone combo in one shot, for muscle, recovery, and sleep.

Recovery & muscleGHRH + GHRP comboResearch only
InMuscle building
Common vial size10 mg
Dose~100 mcg CJC + 200-300 mcg ipa
FrequencyDaily, often at night
RouteUnder the skin (subcutaneous)
StatusResearch only
MixYour choice, calculate it
CycledEach half is cycled on its own schedule, usually 8 to 12 weeks on and 4 off

Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.

01

What is Ipamorelin + CJC-1295 blend?

Plain language first. The technical label stays, but it never stands alone.

Overview

This is a blend of two growth-hormone signals: a GHRH analog (CJC-1295) that sets a steady base and a GHRP (ipamorelin) that adds a pulse. In plain terms: together they nudge your body to release more of its own growth hormone than either alone, in one shot.

What it's used for

The most popular growth-hormone combo in one shot: one part sets a steady base and the other adds a clean pulse, for muscle, fat loss, recovery, and sleep.

02

How does Ipamorelin + CJC-1295 blend work?

What it does in the body, and where.

The blend pairs two different signals that reach growth hormone release by separate routes, which is why they are combined rather than doubled up.

  1. 01
    CJC-1295 sets the base through the GHRH receptor
    Raising how much growth hormone is available to release.
  2. 02
    Ipamorelin adds a pulse through the ghrelin receptor
    Triggering the actual release. A different receptor, so the two do not compete.
  3. 03
    Together they produce more than either alone
    This is the reasoning behind the blend, and it is mechanistically sound even though the human evidence for the combination specifically is thin.
  4. 04
    The ratio varies by product
    There is no standard mix, which is why this page shows no dose flag. Check each component's own page.
Pathway
THE PEPTIDEIpamorelin + CJC-…ACTS ONTwo growth hormone signals at onceRESULTA steady base plus a clean pulse

A schematic of the compound's mechanism, not a diagnostic image.

03

What else is it used for?

Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.

  • Building muscle, losing fat, and recovering fasterResearch only
  • Deeper sleepResearch only
04

How much, and do you cycle it?

The range, and whether you take breaks.

~100 mcg CJC + 200-300 mcg ipa, daily, often at night. Each half is cycled on its own schedule, usually 8 to 12 weeks on and 4 offCommunity practice

The pairing exists because the two halves do not blunt each other. Losing response to a ghrelin-receptor peptide does not reduce the pituitary's response to a GHRH peptide, and the reverse is also true. No study has tested this blend on any schedule.

Source: 24-hour GHRP infusion attenuates the response to a later GHRP bolus (J Clin Endocrinol Metab, 1993)

Compare cycling across compounds →

05

How do I dose and price it?

Enter your vial and your dose. Pick a mix. We show the draw and the cost.

The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.

Your vial size (mg)
Printed on the vial.
What you paid per vial
$
Used for cost per dose only.
Your dose (mg)
Commonly referenced range: ~100 mcg CJC + 200-300 mcg ipaNo range

Choose your mix

your own mL
units · —
Enter your own volume

Measuring the water1 mL = one full 100-unit syringe.

Your draw

20 / 100 units
Full calculator with reorder date →Read a syringe →
06

How do you store it?

Before mixing, and after.

Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.

Unmixed lyophilized Ipamorelin + CJC-1295 blend keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.

07

What are the side effects and cautions?

Known cautions and warnings for this compound.
Handling note

Can cause a histamine flush: temporary flushing, itching, or welts near the injection, usually mild and short-lived. Injecting slowly helps. If it spreads, or you get facial or throat swelling or trouble breathing, treat it as a reaction and get help immediately.

Community notes: what actually helps

What actually helps, according to the people doing it

Nobody's running trials on this. What follows is the folk wisdom that keeps surfacing in Reddit, peptide forums, and the Discord groups, sorted from "probably real" to "someone swears by it." Keep in mind, NONE of this is doctor advice.

Change how you inject (this helps most people)

The tip that comes up most on r/peptides is to add more water. Mix your vial with 3 or 4mL of bac water instead of 1 to 2mL. Same dose, spread thinner, so your skin reacts less.

Small habits people swear by
  • Let it warm to room temperature. Cold stings more.
  • Let the alcohol dry fully before the needle goes in.
  • Inject slow, over five to ten seconds.
  • Move your spot around, at least an inch from last time.
  • For a hard lump, warm compress after. For a red itchy welt, ice.
Treat the itch

This is where Benadryl and Zyrtec come up constantly on the boards. Most people take one 30 to 60 minutes before the shot if they know they tend to react. Claritin works too. Some skip the pill and use Benadryl cream before, or hydrocortisone cream after. Quercetin gets mentioned a lot as the gentler, natural option.

One heads up you'll also see repeated: taking an allergy pill before every shot can hide a real allergy building underneath. That's why some people don't do it by default.

The deeper end

In the more advanced threads, people keep KPV around and inject it when a reaction flares, and say it clears fast. Others try low-dose naltrexone (LDN) as a longer-term fix, but that's real experimenter territory. And a common reminder on the forums: if your reactions are suddenly bad or started with a new vial, the peptide itself might be the problem, not you.

When to stop and get help

Redness that spreads past a couple inches, streaks, feels hot, oozes, or comes with a fever means a possible infection. See a doctor. Hives all over, a swollen face or throat, or trouble breathing is a real allergic reaction. Act on that right away.

Who should avoid it

Check these before anything else.
  • Active cancer, as a precaution with anything raising growth hormone
  • Pregnancy
  • Banned in drug-tested sport

Stop and get help

These are emergencies. Seek care.
  • Signs of an allergic reaction
  • New lumps or masses
  • Spreading hives, face or throat swelling, or trouble breathing

Common effects

Expected, and usually mild.
  • Headache
  • Injection-site reactions
  • Temporary fluid retention
  • Reported in early-stage studies only. There is no large controlled safety database for general use
  • Flushing or a welt near the injection
  • No controlled trials of this specific compound exist, so these are reported rather than measured
  • This is a blend of two growth-hormone peptides, so the cautions of both apply.

Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.

08

Is Ipamorelin + CJC-1295 blend approved?

And where the numbers on this page come from.
Research only

No. Not FDA-approved.

Sold for research use only. Not cleared for human consumption or medical use.

  • DoseFrom research and community reports. No regulator has reviewed this dose.
  • Vial sizeFrom what vendors typically list; not a recommendation.
  • Reviewed22 July 2026
09

What else is like Ipamorelin + CJC-1295 blend?

Others in Muscle building, side by side.

If you're weighing Ipamorelin + CJC-1295 blend, it's worth reading Bimagrumab, IGF-1 LR3, and IGF-1 DES in the same class.

YOU ARE HERE
IPA+CJCBlend
Ipamorelin + CJC-1295 blend

The popular growth-hormone combo in one shot, for muscle, recovery, and sleep.

Research only
Dose
~100 mcg CJC + 200-300 mcg ipa
How often
Daily, often at night
BIMA300 residues
Bimagrumab

An experimental shot that strips fat while adding muscle.

Investigational
Dose
10 up to 30 mg/kg per month (trial doses)
How often
Monthly
LR383 residues
IGF-1 LR3

A powerful muscle-builder that also drops blood sugar hard.

Research only
Dose
0.02 up to 0.05 mg per day (start low, increase slowly)
How often
Daily, cycled
DES67 residues
IGF-1 DES

A short-acting muscle-builder that works right where you inject it.

Research only
Dose
0.05 up to 0.15 mg per dose (start low, increase slowly)
How often
Around training
Compare peptides used to add muscle
10

What these words mean

Show glossary +
Titrate
Starting at a low dose and increasing it slowly over time so your body adjusts and side effects stay mild.
Subcutaneous
An injection just under the skin, into the fat layer, usually with a short, thin insulin needle.
Intramuscular (IM)
An injection into a muscle, using a longer needle.
Reconstitution
Mixing a powdered peptide with liquid (bacteriostatic water) so it can be drawn into a syringe.
Bacteriostatic water
Sterile water with a tiny amount of preservative, used to mix powdered peptides.
Concentration
How strong the mixed peptide is, in milligrams per milliliter (mg/mL). More water makes it weaker; less water makes it stronger.
Units (on the syringe)
The marks on an insulin syringe. 100 units equals 1 mL. They measure how much liquid you draw, not the dose in milligrams.
mcg and mg
Units of dose. 1 milligram (mg) equals 1,000 micrograms (mcg).
GLP-1
A natural gut hormone that lowers appetite and blood sugar. Drugs that copy it, like semaglutide, are used for weight loss.
Growth hormone secretagogue
A compound that nudges your body to release more of its own growth hormone, rather than injecting the hormone itself.
Half-life
How long a compound stays active in your body. A longer half-life means you inject less often.
Peptide vs small molecule
A peptide is a short chain of amino acids. A few items here (like MK-677 or methylene blue) are small molecules, not true peptides, but people use them the same way.
Research only
No approved dose or use in people. Sold for research and not reviewed by the FDA for safety or quality.
Investigational
Still being tested in clinical trials and not yet approved or legally sold for general use.
Banned in drug-tested sport
Prohibited by the World Anti-Doping Agency (WADA); using it can disqualify a competing athlete.

Last reviewed 22 July 2026