CJC-1295 with DAC_Dosage, benefits & legal status
Also known as CJC-1295 DAC, DAC:GRF, CJC-1295 w/ DAC, CJC1295 DAC, CJC-1295 w DAC
A once-or-twice-weekly shot that keeps your growth hormone raised for days.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is CJC-1295 with DAC?
Plain language first. The technical label stays, but it never stands alone.Overview
What it's used for
A long-acting shot that keeps growth hormone raised for days, used to build muscle, burn fat, recover, and sleep better. You inject it only once or twice a week.
How does CJC-1295 with DAC work?
What it does in the body, and where.CJC-1295 copies GHRH, the hormone that tells your pituitary to make growth hormone. The DAC version carries a molecular anchor that keeps it circulating for days rather than minutes.
- 01It copies your growth hormone releasing hormonePrompting the pituitary from upstream, rather than supplying growth hormone directly.
- 02The DAC anchor binds it to a blood proteinThat is what stretches its working life from minutes to roughly a week, and it is the only difference from the no-DAC version.
- 03A raised baseline, not a pulseBecause it stays active for days, it lifts your overall level rather than producing the natural pulses. Whether that matters is genuinely debated.
What else is it used for?
Each group carries its own evidence level.Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
Growth hormone release
Research only- Human trialIn a small early human study, one injection raised growth hormone 2 to 10-fold for more than six days.
- Human trialIGF-1, the hormone growth hormone works through, rose 1.5 to 3-fold for 9 to 11 days.
- Human trialAfter repeated doses, IGF-1 stayed above baseline for up to 28 days.
- No dataIt was never approved, development stopped, and it is banned in drug-tested sport.
The 2 to 10-fold growth hormone numbers come from this DAC version specifically. They are routinely misapplied to the no-DAC version, which behaves completely differently.
The published record
Papers and trials about CJC-1295 with DAC
Searched: CJC-1295, CJC 1295, CJC1295, DAC:GRF.
23 papers tagged human · 11 not reviews or lab · 2 clinical trial publications
1 registered trials · none with posted results
Furthest stage reached: Phase 2, stopped early
Compare this against the whole library →
Nominated but withdrawn; previously category 2RegulatorsCounted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about CJC-1295 with DAC
How much, and do you cycle it?
The range, and whether you take breaks.1 up to 2 mg per dose (start low, increase slowly), 1-2x per week. Commonly cycled, usually 8 to 12 weeks on and 4 off Community practice
Commonly cycled 8 to 12 weeks on and 4 off, and no study has tested that. The argument for it is that this version holds growth hormone at a raised baseline rather than restoring pulses. Worth knowing that when GHRH itself was infused continuously for 14 days in people, the pituitary did not run down. So the tolerance case for cycling this one is an inference from related drugs, not something anyone has measured in it.
6 to 8 daysHuman study
Measured in the ConjuChem trial program.
Source: Teichman SL, et al. J Clin Endocrinol Metab. 2006. PMID 16352683
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
CJC-1295 with DAC starts at $25.00 across 81 vendors, typically $7.20 – $21.50 per mg.
111 listings, last read Oct 24, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized CJC-1295 with DAC keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Can cause a histamine flush: temporary flushing, itching, or welts near the injection, usually mild and short-lived. Injecting slowly helps. If it spreads, or you get facial or throat swelling or trouble breathing, treat it as a reaction and get help immediately.
Solubility, computed: 33% charged residues, 43% hydrophobic. Water usually sufficient.
A first-pass rule from peptide manufacturers' guidance. It does not account for disulfide bridges, salt form or how the powder was dried, and it predicts what should be easy rather than what will happen in your vial.
Who should avoid it
- Active cancer
- Pregnancy
- Banned in drug-tested sport
Stop and get help
- Spreading hives, face or throat swelling, or trouble breathing
- New lumps or masses
Common effects
- Flushing, itching, or a welt near the injection, which is a histamine effect rather than an allergy
- Water retention
- Tingling in the hands
- Tiredness
- Because it lasts for days, any effect lingers
What actually helps, according to the people doing it
Nobody's running trials on this. What follows is the folk wisdom that keeps surfacing in Reddit, peptide forums, and the Discord groups, sorted from "probably real" to "someone swears by it." Keep in mind, NONE of this is doctor advice.
Change how you inject (this helps most people)
The tip that comes up most on r/peptides is to add more water. Mix your vial with 3 or 4mL of bac water instead of 1 to 2mL. Same dose, spread thinner, so your skin reacts less.
Small habits people swear by
- 1Let it warm to room temperature. Cold stings more.
- 2Let the alcohol dry fully before the needle goes in.
- 3Inject slow, over five to ten seconds.
- 4Move your spot around, at least an inch from last time.
- 5For a hard lump, warm compress after. For a red itchy welt, ice.
Treat the itch
This is where Benadryl and Zyrtec come up constantly on the boards. Most people take one 30 to 60 minutes before the shot if they know they tend to react. Claritin works too. Some skip the pill and use Benadryl cream before, or hydrocortisone cream after. Quercetin gets mentioned a lot as the gentler, natural option.
One heads up you'll also see repeated: taking an allergy pill before every shot can hide a real allergy building underneath. That's why some people don't do it by default.
The deeper end
In the more advanced threads, people keep KPV around and inject it when a reaction flares, and say it clears fast. Others try low-dose naltrexone (LDN) as a longer-term fix, but that's real experimenter territory. And a common reminder on the forums: if your reactions are suddenly bad or started with a new vial, the peptide itself might be the problem, not you.
Redness that spreads past a couple inches, streaks, feels hot, oozes, or comes with a fever means a possible infection. See a doctor. Hives all over, a swollen face or throat, or trouble breathing is a real allergic reaction. Act on that right away.
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is CJC-1295 with DAC approved?
And where the numbers on this page come from.No. CJC-1295 with DAC is not approved for any use, anywhere. It is sold labeled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin (subcutaneous)
- Checked22 July 2026
- DoseFrom community reports. No regulator or trial established this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
What regulators say
From official documentsNominated but withdrawn; previously category 2
FDA identified serious adverse events including increased heart rate and systemic vasodilatory reaction
Checked 11 September 2026FDA: Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks (category 2 and withdrawn nominations), current as of April 22, 2026Prohibited at all times, in and out of competition. S2.2.4 Growth hormone releasing factors: GHRH and its analogues (e.g. CJC-1293, CJC-1295, sermorelin and tesamorelin). Non-Specified.
Checked 12 September 2026WADA: The 2026 Prohibited List (in force 1 January 2026)
Banned in drug-tested sport. Most research peptides are prohibited under WADA's S0 category, which covers any substance with no approval from any regulatory authority for human use. That means a compound can be banned without ever being named on the prohibited list. Check with your own anti-doping authority rather than assuming absence from the list means permitted.
You can compare this against the whole library, or read how to check a seller.
What else is like CJC-1295 with DAC?
Others in Growth hormone peptides, side by side.If you're weighing CJC-1295 with DAC, it's worth reading Tesamorelin + Ipamorelin blend, CJC-1295 (no DAC) + GHRP-2 blend, and GHRP-2 in the same class.
A once-or-twice-weekly shot that keeps your growth hormone raised for days.
- Dose
- 1 up to 2 mg per dose (start low, increase slowly)
- How often
- 1-2x per week
Two growth-hormone signals in one shot, built around the belly-fat peptide.
- Dose
- 1.28 up to 2 mg tesamorelin per day (the ipamorelin follows your ratio)
- How often
- Daily, often at night
A growth hormone pairing in one vial, where the CJC-1295 dose sets the GHRP-2 dose whether you want it to or not.
- Dose
- 0.1 mg CJC-1295 (no DAC) per dose (the rest follows your ratio)
- How often
- Daily, often at night
A shot that spikes your own growth hormone to build muscle and recover.
- Dose
- 0.1 up to 0.3 mg per dose (start low, increase slowly)
- How often
- 1-3x daily
Compared with
Two GHRH analogs tested for the same condition. One completed two Phase 3 trials and got approved. The other's Phase 2 was halted in 2006 and never restarted.
Read comparison →One name, two drugs: one has a measured half-life and three published human trials, the other has never been tested in a person.
Read comparison →They act on different receptors and are usually sold in the same vial. Each has human trials; the combination everyone buys has none.
Read comparison →Three act on the GHRH receptor and one copies ghrelin. Only tesamorelin is approved, and the two with the weakest outcome data were both voted down by the FDA in late 2024.
Read comparison →Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- Why Does My Peptide Injection Itch or Welt
Injection-site irritation, a histamine reaction, or a true allergy, and how to tell them apart.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
Sources
Beyond these, 42 records are indexed. Browse the records