CJC-1295 with DAC_Dosage, benefits & legal status
Also known as CJC-1295 DAC, DAC:GRF
A once-or-twice-weekly shot that keeps your growth hormone raised for days.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is CJC-1295 with DAC?
Plain language first. The technical label stays, but it never stands alone.Overview
It raises your own growth hormone steadily from a single weekly or twice-weekly shot.
CJC-1295 with DAC is a long-acting GHRH analog, a copy of the hormone that tells your body to make growth hormone, with a molecular anchor ('DAC') that keeps it working for days.
What it's used for
A long-acting shot that keeps growth hormone raised for days, used to build muscle, burn fat, recover, and sleep better. You inject it only once or twice a week.
How does CJC-1295 with DAC work?
What it does in the body, and where.CJC-1295 copies GHRH, the hormone that tells your pituitary to make growth hormone. The DAC version carries a molecular anchor that keeps it circulating for days rather than minutes.
- 01It copies your growth hormone releasing hormonePrompting the pituitary from upstream, rather than supplying growth hormone directly.
- 02The DAC anchor binds it to a blood proteinThat is what stretches its working life from minutes to roughly a week, and it is the only difference from the no-DAC version.
- 03A raised baseline, not a pulseBecause it stays active for days, it lifts your overall level rather than producing the natural pulses. Whether that matters is genuinely debated.
What else is it used for?
Each group carries its own evidence level.Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
Growth hormone release
Research only- Human trialIn a small early human study, one injection raised growth hormone 2 to 10-fold for more than six days.
- Human trialIGF-1, the hormone growth hormone works through, rose 1.5 to 3-fold for 9 to 11 days.
- Human trialAfter repeated doses, IGF-1 stayed above baseline for up to 28 days.
- RegulatoryIt was never approved, development stopped, and it is banned in drug-tested sport.
The 2 to 10-fold growth hormone numbers come from this DAC version specifically. They are routinely misapplied to the no-DAC version, which behaves completely differently.
The published record
38
Records indexed for CJC-1295 with DAC
22 in humans, 11 of them original studies.
1 registered trials, 0 with posted results.
FDA: Nominated but withdrawn; previously category 2.
Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 12 September 2026.
At a glance
Four things to know about CJC-1295 with DAC
Evidence
Research only
Category
Growth hormone
Common vial
5 mg
Half-life
6 to 8 days
How much, and do you cycle it?
The range, and whether you take breaks.1 up to 2 mg per dose (start low, increase slowly), 1-2x per week. Commonly cycled, usually 8 to 12 weeks on and 4 offCommunity practice
Commonly cycled 8 to 12 weeks on and 4 off, and no study has tested that. The argument for it is that this version holds growth hormone at a raised baseline rather than restoring pulses. Worth knowing that when GHRH itself was infused continuously for 14 days in people, the pituitary did not run down. So the tolerance case for cycling this one is an inference from related drugs, not something anyone has measured in it.
How long does it stay in the body?
The half-life, and where the figure comes from.6 to 8 daysHuman study
Measured in the ConjuChem trial programme.
Source: Teichman SL, et al. J Clin Endocrinol Metab. 2006. PMID 16352683
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
40 / 100 unitsCJC-1295 with DAC starts at $29.99 across 30 vendors, typically $7.20 – $23.63 per mg.
47 listings, last read Sep 6, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized CJC-1295 with DAC keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Can cause a histamine flush: temporary flushing, itching, or welts near the injection, usually mild and short-lived. Injecting slowly helps. If it spreads, or you get facial or throat swelling or trouble breathing, treat it as a reaction and get help immediately.
Who should avoid it
- Active cancer
- Pregnancy
- Banned in drug-tested sport
Stop and get help
- Spreading hives, face or throat swelling, or trouble breathing
- New lumps or masses
Common effects
- Flushing, itching, or a welt near the injection, which is a histamine effect rather than an allergy
- Water retention
- Tingling in the hands
- Tiredness
- Because it lasts for days, any effect lingers
What regulators say
- FDA: Certain Bulk Drug Substances for Use in Compounding that May Present Significant Safety Risks (category 2 and withdrawn nominations), current as of April 22, 2026Nominated but withdrawn; previously category 2
FDA identified serious adverse events including increased heart rate and systemic vasodilatory reaction
Checked 11 September 2026
What actually helps, according to the people doing it
Nobody's running trials on this. What follows is the folk wisdom that keeps surfacing in Reddit, peptide forums, and the Discord groups, sorted from "probably real" to "someone swears by it." Keep in mind, NONE of this is doctor advice.
Change how you inject (this helps most people)
The tip that comes up most on r/peptides is to add more water. Mix your vial with 3 or 4mL of bac water instead of 1 to 2mL. Same dose, spread thinner, so your skin reacts less.
Small habits people swear by
- 1Let it warm to room temperature. Cold stings more.
- 2Let the alcohol dry fully before the needle goes in.
- 3Inject slow, over five to ten seconds.
- 4Move your spot around, at least an inch from last time.
- 5For a hard lump, warm compress after. For a red itchy welt, ice.
Treat the itch
This is where Benadryl and Zyrtec come up constantly on the boards. Most people take one 30 to 60 minutes before the shot if they know they tend to react. Claritin works too. Some skip the pill and use Benadryl cream before, or hydrocortisone cream after. Quercetin gets mentioned a lot as the gentler, natural option.
One heads up you'll also see repeated: taking an allergy pill before every shot can hide a real allergy building underneath. That's why some people don't do it by default.
The deeper end
In the more advanced threads, people keep KPV around and inject it when a reaction flares, and say it clears fast. Others try low-dose naltrexone (LDN) as a longer-term fix, but that's real experimenter territory. And a common reminder on the forums: if your reactions are suddenly bad or started with a new vial, the peptide itself might be the problem, not you.
Redness that spreads past a couple inches, streaks, feels hot, oozes, or comes with a fever means a possible infection. See a doctor. Hives all over, a swollen face or throat, or trouble breathing is a real allergic reaction. Act on that right away.
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is CJC-1295 with DAC approved?
And where the numbers on this page come from.No. CJC-1295 with DAC is not approved for any use, anywhere. It is sold labelled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin (subcutaneous)
- CheckedJuly 2026
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
Banned in drug-tested sport. Most research peptides are prohibited under WADA's S0 category, which covers any substance with no approval from any regulatory authority for human use. That means a compound can be banned without ever being named on the prohibited list. Check with your own anti-doping authority rather than assuming absence from the list means permitted.
You can compare this against the whole library, or read how to check a seller.
- DoseFrom research and community reports. No regulator has reviewed this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
- Reviewed22 July 2026
What else is like CJC-1295 with DAC?
Others in Growth hormone peptides, side by side.If you're weighing CJC-1295 with DAC, it's worth reading CJC-1295 no DAC (Mod GRF 1-29), Sermorelin, and Tesamorelin in the same class.
A once-or-twice-weekly shot that keeps your growth hormone raised for days.
- Dose
- 1 up to 2 mg per dose (start low, increase slowly)
- How often
- 1-2x per week
A short-acting growth-hormone pulse, usually paired with ipamorelin.
- Dose
- 0.1 mg per dose
- How often
- Daily to 2x daily
A gentle shot that prompts your body to make more of its own growth hormone.
- Dose
- 0.2 up to 0.5 mg per dose (start low, increase slowly)
- How often
- Daily/nightly
An approved shot proven to shrink stubborn belly fat.
- Dose
- 1.28 up to 2 mg per day, depending on which product you have
- How often
- Daily
Compared with
Two GHRH analogs tested for the same condition. One completed two Phase 3 trials and got approved. The other's Phase 2 was halted in 2006 and never restarted.
Read comparison →One name, two drugs: one has a measured half-life and three published human trials, the other has never been tested in a person.
Read comparison →They act on different receptors and are usually sold in the same vial. Each has human trials; the combination everyone buys has none.
Read comparison →Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- Why Does My Peptide Injection Itch or Welt
Injection-site irritation, a histamine reaction, or a true allergy, and how to tell them apart.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
Sources
- Teichman CJC-1295 trial, Journal of Clinical Endocrinology and Metabolism, 2006(2006)The human trial behind every claim made for this compound, and it is smaller and narrower than its reputation. Two randomised, placebo-controlled, double-blind ascending-dose studies, lasting 28 and 49 days, at two sites, in healthy adults aged 21 to 61. A single subcutaneous injection raised mean plasma growth hormone two to ten-fold for six days or more and IGF-I one and a half to three-fold for nine to eleven days, with a measured half-life of 5.8 to 8.1 days. After repeat doses IGF-I stayed above baseline for up to 28 days. No serious adverse reactions, and tolerability was best at 30 or 60 micrograms per kilogram. Read the outcome measures before reading anything into it: the endpoints were hormone concentrations in blood, not muscle, fat, strength, sleep, recovery or any clinical outcome at all. The molecule tested is specifically the drug affinity complex version, which binds covalently to albumin, and three of the six authors were employed by the company developing it.
Last reviewed 22 July 2026
Beyond these, 38 records are indexed. Browse the records