Humanin_Dosage, benefits & legal status
Also known as HN
A natural longevity peptide studied for cell protection and aging.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Humanin?
Plain language first. The technical label stays, but it never stands alone.Overview
It acts as a cell-protective, stress-resistance signal, which is why it is studied for brain, metabolic, and aging support. Human data is limited.
Humanin is a mitochondrial-derived peptide, a short chain encoded inside your mitochondria's own DNA.
What it's used for
A naturally occurring longevity peptide studied for protecting cells, the brain, and metabolism as you age.
How does Humanin work?
What it does in the body, and where.Humanin, like MOTS-c, is encoded inside your mitochondria's own small genome rather than in the DNA of the cell nucleus.
- 01It acts as a cell-protection signalSuppressing the pathways that lead a stressed cell to destroy itself.
- 02Levels fall with age, and correlate with healthPeople with higher circulating humanin tend to be healthier, and the children of centenarians have more of it.
- 03Correlation is where the human evidence stopsNo trial has given humanin to people to see what happens. That levels track with health does not establish that raising them causes it.
A schematic of the compound's mechanism, not a diagnostic image.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Protecting cells from stress and supporting healthy agingResearch only
- Brain and metabolic protectionResearch only
The published record
Papers and trials about Humanin
Searched: Humanin.
Left out: HN (too short).
257 papers tagged human · 156 not reviews or lab · 7 clinical trial publications
3 registered trials · none with posted results
Furthest stage reached: Published trials only, 7 clinical trial publications, no phased trial registered
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count. 461 papers and 3 trials indexed in detail.
At a glance
Four things to know about Humanin
Evidence
Category
Weight loss and metabolic
Common vial
10 mg
Half-life
Nothing published
How much, and do you cycle it?
The range, and whether you take breaks.Research only, as studied. No established schedule No range
No published study has established how long to take this or whether a break is needed. Schedules quoted online come from vendors and forums, and different sources disagree.
Nothing publishedNo figure
No human study exists. The published work is in mice and rats and measures effects rather than clearance.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Humanin starts at $46.00 across 25 vendors, typically $6.90 – $15.00 per mg.
25 listings, last read Oct 24, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Humanin keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Solubility, computed: 33% charged residues, 58% hydrophobic. Water usually sufficient.
A first-pass rule from peptide manufacturers' guidance. It does not account for disulfide bridges, salt form or how the powder was dried, and it predicts what should be easy rather than what will happen in your vial.
Who should avoid it
- Pregnancy or breastfeeding
- Active cancer, as a precaution with anything that promotes tissue or blood-vessel growth
- Any prescription medicine you take regularly, without checking for interactions first
- Anyone who wants established safety data, because none exists for this compound in humans
Stop and get help
- Spreading hives, swelling of the face or throat, or trouble breathing, which can happen with any injection and is a medical emergency
- Redness, heat, or pus at the injection site, which can signal infection
- Any severe or unexpected symptom
- Anything unusual, since there is no known safety profile to compare it against
Common effects
- Little human data.
- Redness, soreness, or a small bump at the injection site
- Beyond the above, unknown. There is no reliable human data on what this compound commonly causes
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Humanin approved?
And where the numbers on this page come from.No. Humanin is not approved for any use, anywhere. It is sold labeled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin (subcutaneous)
- Checked22 September 2026
- DoseFrom community reports. No regulator or trial established this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesNone traced yet.
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
You can compare this against the whole library, or read how to check a seller.
If you're weighing Humanin, it's worth reading Pancragen, GW501516 (Cardarine), and ATX-304 (O-304) in the same class.
A natural longevity peptide studied for cell protection and aging.
- Dose
- Research only
- How often
- As studied
A lab-made 4 amino acid peptide aimed at the pancreas.
- Dose
- Research only
- How often
- Daily, in 10-20 day courses
A discontinued drug whose development stopped over cancer in multiple organs.
- Dose
- 2.5 up to 10 mg per day
- How often
- Once daily in the trials
An exercise mimetic that got through a phase 2a trial and then went quiet.
- Dose
- 400 mg per day
- How often
- Once daily in the trial
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence
Beyond these, 464 records are indexed. Browse the records