Humanin_Dosage, benefits & legal status
Also known as HN
A natural longevity peptide studied for cell protection and aging.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Humanin?
Plain language first. The technical label stays, but it never stands alone.Overview
It acts as a cell-protective, stress-resistance signal, which is why it is studied for brain, metabolic, and aging support. Human data is limited.
Humanin is a mitochondrial-derived peptide, a short chain encoded inside your mitochondria's own DNA.
What it's used for
A naturally occurring longevity peptide studied for protecting cells, the brain, and metabolism as you age.
How does Humanin work?
What it does in the body, and where.Humanin, like MOTS-c, is encoded inside your mitochondria's own small genome rather than in the DNA of the cell nucleus.
- 01It acts as a cell-protection signalSuppressing the pathways that lead a stressed cell to destroy itself.
- 02Levels fall with age, and correlate with healthPeople with higher circulating humanin tend to be healthier, and the children of centenarians have more of it.
- 03Correlation is where the human evidence stopsNo trial has given humanin to people to see what happens. That levels track with health does not establish that raising them causes it.
A schematic of the compound's mechanism, not a diagnostic image.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Protecting cells from stress and supporting healthy agingResearch only
- Brain and metabolic protectionResearch only
The published record
584
Records indexed for Humanin400 papers and 3 trials indexed in detail.
221 in humans, 140 of them original studies.
3 registered trials, 0 with posted results.
Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 11 September 2026.
At a glance
Four things to know about Humanin
Evidence
Research only
Category
Weight loss and metabolic
Common vial
10 mg
Half-life
Nothing published in humans
How much, and do you cycle it?
The range, and whether you take breaks.Research only, as studied. No established scheduleNo range
No published study has established how long to take this or whether a break is needed. Schedules quoted online come from vendors and forums, and different sources disagree.
How long does it stay in the body?
The half-life, and where the figure comes from.Nothing published in humansNo figure
No human pharmacokinetic study exists. Clearance has been measured in rodents, but on the analogue HNG rather than humanin itself, given by intraperitoneal injection to male mice and male rats, with a longer half-life in rats than in mice. No usable figure in hours has been traced to a primary source, so none is shown here.
Source: https://academic.oup.com/endo/article-abstract/154/10/3739/2423999?redirectedFrom=fulltext
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
0 / 100 unitsHumanin starts at $48.40 across 11 vendors, typically $8.00 – $14.70 per mg.
13 listings, last read Sep 4, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Humanin keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Pregnancy or breastfeeding
- Active cancer, as a precaution with anything that promotes tissue or blood-vessel growth
- Any prescription medicine you take regularly, without checking for interactions first
- Anyone who wants established safety data, because none exists for this compound in humans
Stop and get help
- Spreading hives, swelling of the face or throat, or trouble breathing, which can happen with any injection and is a medical emergency
- Redness, heat, or pus at the injection site, which can signal infection
- Any severe or unexpected symptom
- Anything unusual, since there is no known safety profile to compare it against
Common effects
- Little human data.
- Redness, soreness, or a small bump at the injection site
- Beyond the above, unknown. There is no reliable human data on what this compound commonly causes
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Humanin approved?
And where the numbers on this page come from.No. Humanin is not approved for any use, anywhere. It is sold labelled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin (subcutaneous)
- CheckedJuly 2026
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
You can compare this against the whole library, or read how to check a seller.
- DoseFrom research and community reports. No regulator has reviewed this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
- Reviewed22 July 2026
What else is like Humanin?
Others in Fat loss without GLP-1, side by side.If you're weighing Humanin, it's worth reading Melanotan II, Adipotide, and BAM15 in the same class.
A natural longevity peptide studied for cell protection and aging.
- Dose
- Research only
- How often
- As studied
A shot for a fast, deep tan, plus libido and appetite effects.
- Dose
- 0.25 up to 1 mg per dose (start low, increase slowly)
- How often
- Daily loading, then maintenance
An experimental fat-loss peptide considered dangerous, with no safe human use.
- Dose
- Research only
- How often
- Research only
A fat-loss compound built to do what DNP does without killing people.
- Dose
- Research only
- How often
- Varies
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
- Yen et al., Humanin prevents age-related cognitive decline in mice and is associated with improved cognitive age in humans (Scientific Reports 8:14212)(2018)The title joins two halves that were done on different things, and the join is where the marketing happens. The mouse half gave HNG, an analogue with glycine substituted for serine at position 14, not humanin, by intraperitoneal injection at 4 mg/kg twice weekly to female mice from 18 months of age. Rotarod performance was better after six months of treatment, but at ten months the same difference had shrunk and was no longer significant. The maze results rest on small subsets, seven to eight animals per group on the Barnes maze and ten per group on the Y-maze, and there was no difference in hippocampal neurogenesis. The human half involved no administration at all: plasma humanin was measured in 71 African American and 75 Caucasian American participants, a mitochondrial variant (rs2854128) was associated with roughly 14% lower circulating humanin, and that variant tracked with cognitive age in a separate cohort. The authors state plainly that the human findings are correlative. Two of them disclose consulting for and stock in a company developing humanin analogues.
- Chin et al., Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents (Endocrinology)(2013)Pharmacokinetics for this family do exist, and knowing what they cover is the point. The peptides injected were the analogues HNG and HNGF6A rather than humanin itself, given intraperitoneally to male mice and male Sprague Dawley rats. Half-life differed by species, longer in rats than in mice, and differed by analogue, with HNGF6A lasting longer than HNG in wild-type mice. The tissue distribution is the part worth reading twice: in rats the peptide was highest in plasma, present in liver, and undetectable in brain and heart. A compound sold on brain and heart protection was not measurably reaching either organ in the one study that looked. Sex was male throughout, species was rodent, and one author was affiliated with a company developing these analogues commercially.
Last reviewed 22 July 2026
Beyond these, 403 records are indexed. Browse the records