Enclomiphene_Dosage, benefits & legal status
Also known as enclomiphene citrate, trans-clomiphene, Androxal, EC
Half of the fertility drug Clomid, sold on its own for testosterone.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Enclomiphene?
Plain language first. The technical label stays, but it never stands alone.Overview
It stops the brain from seeing estrogen, so the brain tells the testicles to make more testosterone.
Enclomiphene is the trans-isomer of clomiphene, a selective estrogen receptor modulator that blocks estrogen feedback at the pituitary so LH, FSH and testosterone all rise.
What it's used for
A daily capsule taken to raise testosterone without switching off sperm production the way a testosterone gel does.
How does Enclomiphene work?
What it does in the body, and where.Enclomiphene works on the brain rather than on the testicles.
- 01It blocks estrogen receptors in the pituitaryEstrogen normally tells the pituitary that hormone levels are fine. Blocking that signal removes the brake.
- 02LH and FSH riseThese are the two signals the pituitary sends to the testicles.
- 03The testicles make more testosterone, and keep workingThis is the difference people are buying. A testosterone gel replaces the hormone and shuts the axis down. This raises the hormone by driving the axis harder.
- 04Estradiol rises as wellMore testosterone means more raw material for aromatase. People who take it expecting an estrogen blocker are often surprised by their bloodwork.
A schematic of the compound's mechanism, not a diagnostic image.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Raising testosterone in men with secondary hypogonadismInvestigational
- Keeping sperm counts up while testosterone risesInvestigational
- Restarting the hormone axis after a testosterone or anabolic cycleResearch only
The published record
Papers and trials about Enclomiphene
135 papers tagged human · 26 not reviews or lab · 7 clinical trial publications
261 registered trials · 14 with posted results
Furthest stage reached: Phase 3 or later, completed, no results posted
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Category 1RegulatorsCounted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count. 150 papers and 100 trials indexed in detail.
At a glance
Four things to know about Enclomiphene
Evidence
Clinical use
Category
Sexual and hormonal
Common vial
Varies
Half-life
About 10 hours
How much, and do you cycle it?
The range, and whether you take breaks.12.5 up to 25 mg per day, daily. Continuous in the trials Trial dose
Both phase 3 trials dosed daily for three months with no planned break, and an open-label extension continued daily 12.5 mg for up to a year. The post-cycle use it is sold for, a short course to restart the axis, is not the way it was studied.
About 10 hoursHuman study
This is the short-acting half of clomiphene, isolated. Peak concentration comes 2 to 3 hours after a dose. The hormone effect lasts far longer than the drug, with raised testosterone, LH and FSH persisting at least 7 days after stopping.
Source: Wiehle R, et al. Fertil Steril 2014, ZA-203 randomized phase II. Review: PMC5009465.
You can compare this against the whole library to see where it sits.
What does it cost?
Typical dose and cost, in plain numbers.Enclomiphene is not injected
It is taken by mouth (oral). Both phase 3 trials tested exactly two doses, 12.5 mg and 25 mg once daily, for three months. There is no approved label, so there is no official dose above or below that.
Enclomiphene starts at $79.95 across 5 vendors, typically $4.40 per mg.
5 listings, last read Oct 10, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Room temperature. Cool, dry, out of light.
Enclomiphene is taken as a pill or capsule. Keep it in its original container at room temperature, away from heat, humidity, and direct sun. No fridge or mixing needed. Check the expiration date on the bottle.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- A history of blood clots, stroke or clotting disorders, which applies to this whole drug class
- Existing liver disease
- Any hormone-sensitive cancer
- Pregnancy, and anyone who could become pregnant
- Banned in drug-tested sport
Stop and get help
- Blurred vision, flashes, floaters or any change in how you see, which is a known class effect
- Swelling, pain or warmth in one leg, or sudden shortness of breath
- Yellowing of the skin or eyes, or dark urine
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Headache
- Nausea
- Dizziness
- Mood changes
- Rising estradiol, since more testosterone means more substrate for aromatase
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Enclomiphene approved?
And where the numbers on this page come from.Not approved, but legal to obtain. Enclomiphene has no FDA approval, and it can be prescribed or prepared by a compounding pharmacy in the United States.
- Approval statusClinical use
- RouteBy mouth (oral)
- Checked24 August 2026
- DoseFrom published clinical trials. Not approved by a regulator for this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
What has happened recently
Never approved anywhere. Repros Therapeutics applied for approval as Androxal and received a Complete Response Letter on 1 December 2015, in which the FDA said the phase 3 design was no longer adequate to demonstrate clinical benefit and asked for at least one further phase 3 study. That study was never run and development was dropped. In June 2022 the FDA's Pharmacy Compounding Advisory Committee voted against putting enclomiphene citrate on the final 503A bulks list. It nonetheless still sits in category 1 of the FDA's nominated bulk substances list as of May 2026, meaning under evaluation, and that is what keeps compounding-pharmacy supply legal for now. Prohibited in sport at all times by WADA under section S4.
What regulators say
From official documentsCategory 1
Listed as Enclomiphene Citrate
Checked 11 September 2026FDA: Bulk Drug Substances Nominated for Use in Compounding Under Section 503A (interim categories 1, 2, 3), updated May 14, 2026Prohibited at all times, in and out of competition. S4.2 Anti-estrogenic substances; clomifene named, and the class covers substances with a similar chemical structure. Specified Substance.
Checked 12 September 2026WADA: The 2026 Prohibited List (in force 1 January 2026)
Banned in drug-tested sport. Most research peptides are prohibited under WADA's S0 category, which covers any substance with no approval from any regulatory authority for human use. That means a compound can be banned without ever being named on the prohibited list. Check with your own anti-doping authority rather than assuming absence from the list means permitted.
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What else is like Enclomiphene?
Others in Sexual and hormonal, side by side.If you're weighing Enclomiphene, it's worth reading Tamoxifen, TRH (Protirelin), and Letrozole in the same class.
Half of the fertility drug Clomid, sold on its own for testosterone.
- Dose
- 12.5 up to 25 mg per day
- How often
- Daily
A breast cancer drug with a boxed warning, sold as a gyno fix.
- Dose
- 20 up to 40 mg per day
- How often
- Daily
The brain hormone behind a discontinued thyroid test, often sold under the wrong name.
- Dose
- Set by the label
- How often
- Once, for a test
The stronger aromatase inhibitor, and the one with the clearest bone cost.
- Dose
- 2.5 mg per day
- How often
- Daily
Guides for this compound
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
Sources
- Repros Therapeutics, Complete Response Letter announcement, SEC filing(2015)FDA said the phase 3 design was no longer adequate to demonstrate clinical benefit.
- FDA, bulk drug substances nominated under section 503A(2026)Enclomiphene citrate listed in category 1, under evaluation, as of 14 May 2026.
- US Department of Defense, Operation Supplement Safety on clomiphene and enclomiphene(2025)Both are drugs rather than supplements, and clomiphene is not approved for any use in men.
Beyond these, 250 records are indexed. Browse the records