HMG (Menotropin)_Dosage, benefits & legal status
Also known as menotropin, Menopur, human menopausal gonadotropin, HMG
A fertility hormone shot that drives sperm or egg production.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is HMG (Menotropin)?
Plain language first. The technical label stays, but it never stands alone.Overview
It supplies those two signals directly. Doctors use it to help with fertility. Sometimes it is used alongside testosterone therapy.
HMG (menotropin) is a fertility medication containing both FSH and LH, the two pituitary hormones that drive egg and sperm production.
What it's used for
A fertility hormone shot that supplies the two signals needed to drive sperm or egg production, used in fertility treatment and sometimes with testosterone therapy.
How does HMG (Menotropin) work?
What it does in the body, and where.HMG is purified from the urine of postmenopausal women, whose pituitaries produce large amounts of FSH and LH. It supplies both.
- 01It provides FSH and LH togetherFSH drives sperm and follicle development; LH drives testosterone and ovulation. Most fertility drugs supply only one.
- 02It acts directly on the gonadsBypassing both the brain and the pituitary.
- 03It is a purified biological productComposition and the exact FSH-to-LH ratio vary by preparation, which matters clinically.
- 04Overstimulation is a real riskIn women, ovarian hyperstimulation syndrome, which is why fertility treatment is monitored with scans and blood tests rather than dosed by protocol alone.
Where this compound is thought to act.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Growing multiple follicles during fertility treatment, which is its approved useFDA-approved
- Supporting sperm production in men, used off-labelClinical use
The published record
1,717
Records indexed for HMG (Menotropin)400 papers and 100 trials indexed in detail.
371 in humans, 239 of them original studies.
170 registered trials, 4 with posted results among the 100 indexed.
Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 12 September 2026.
At a glance
Four things to know about HMG (Menotropin)
Evidence
Clinical use
Category
Sexual and hormonal
Common vial
75 IU
Half-life
11 to 13 hours for the FSH component
How much, and do you cycle it?
The range, and whether you take breaks.75 up to 150 IU per dose (start low, increase slowly), several per week. Given within a treatment cycle, roughly 7 to 12 days, then stoppedFDA label
Dosed daily through an ovarian stimulation cycle and adjusted by monitoring, then stopped. The cycle is the treatment, not a break from it.
How long does it stay in the body?
The half-life, and where the figure comes from.11 to 13 hours for the FSH componentFDA label
Menopur carries both FSH and LH activity and the label gives a figure only for FSH, stating that LH kinetics were not studied. This is also a multiple-dose figure. The true terminal half-life of FSH is closer to 17 hours, so the 3 to 4 hours quoted elsewhere is a distribution phase rather than elimination.
Source: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=22c8db95-c3db-1770-8086-31356fbabe35
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
200 / 100 unitsHMG (Menotropin) starts at $44.99 across 3 vendors.
3 listings, last read Sep 4, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized HMG (Menotropin) keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Pregnancy, where it can harm a developing baby
- A previous allergic reaction to this class
- Ovaries that have stopped working, shown by a high FSH level
- Untreated thyroid or adrenal problems
- Tumours of the breast or reproductive organs that respond to hormones
- Pituitary or hypothalamic tumours
- Unexplained abnormal vaginal bleeding
- Ovarian cysts or enlarged ovaries not caused by PCOS
Stop and get help
- Severe pelvic pain with bloating, rapid weight gain, nausea, or shortness of breath, which can signal ovarian overstimulation and needs emergency care
- Sudden severe one-sided pelvic pain, which can signal a twisted ovary
- Swelling, pain, or warmth in a leg, or chest pain and breathlessness, which can signal a blood clot
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Abdominal cramps, bloating, and pain
- Headache
- Injection-site pain and inflammation
- Pelvic pain
- Breast tenderness
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is HMG (Menotropin) approved?
And where the numbers on this page come from.Not approved, but legal to obtain. HMG (Menotropin) has no FDA approval, and it can be prescribed or prepared by a compounding pharmacy in the United States.
- Approval statusClinical use
- RouteUnder the skin or into muscle
- CheckedSeptember 2026
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
You can compare this against the whole library, or read how to check a seller.
- DoseFrom product labeling and clinical guidelines.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
- Reviewed8 September 2026
What else is like HMG (Menotropin)?
Others in Sexual and hormonal, side by side.If you're weighing HMG (Menotropin), it's worth reading Oxytocin, Testagen, and Prostamax in the same class.
A fertility hormone shot that drives sperm or egg production.
- Dose
- 75 up to 150 IU per dose (start low, increase slowly)
- How often
- Several per week
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- Dose
- 18 up to 40 IU per dose
- How often
- As needed
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- Dose
- Research only
- How often
- Daily, in 10-20 day courses
A lab-made 4 amino acid peptide aimed at the prostate.
- Dose
- Research only
- How often
- Daily, in 10-20 day courses
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
Sources
- DailyMed, MENOPUR (menotropins) prescribing information(2026)Current label. Elimination half-life for the FSH component 11 to 13 hours, and similar whether given subcutaneously or intramuscularly.
- FDA, MENOPUR original approval label(2004)Original approval. Distribution and metabolism of FSH and LH from Menopur have not been studied in humans.
Last reviewed 8 September 2026
Beyond these, 500 records are indexed. Browse the records