ACE-031 (Ramatercept)_
Also known as ramatercept
An experimental muscle-builder whose development was paused over side effects.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is ACE-031 (Ramatercept)?
Plain language first. The technical label stays, but it never stands alone.Overview
ACE-031 (ramatercept) is a decoy receptor that soaks up myostatin and activin, the signals that limit muscle. In plain terms: by mopping up those brakes it lets muscle grow, but its development was paused over side effects.
What it's used for
An experimental muscle-builder that soaks up the natural brakes on muscle, producing big gains in studies.
How does ACE-031 (Ramatercept) work?
What it does in the body, and where.ACE-031 is a decoy: a piece of the receptor that myostatin binds to, floating free in the blood so myostatin binds it instead of muscle.
- 01It soaks up myostatin and activinBoth signals that limit muscle growth, intercepted before they reach the receptor.
- 02Muscle grew in trialsIt reached phase 2 in Duchenne muscular dystrophy and did increase muscle mass.
- 03Development was stopped over blood vessel effectsNosebleeds, gum bleeding, and small dilated vessels in the skin. Activin signalling turns out to matter for blood vessels as well as muscle.
- 04It is here for referenceThis is a discontinued drug, not an option.
Where this compound is thought to act.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Muscle growth by soaking up the signals that limit itResearch only
- Duchenne muscular dystrophy, where the trial was halted in 2011 over bleeding side effectsInvestigational
How much, and do you cycle it?
The range, and whether you take breaks.Trial doses, cycled. No schedule exists. Development was haltedTrial dose
Stopped in 2013 during phase 2 in Duchenne muscular dystrophy after nosebleeds and small vessel changes appeared. Whatever schedules circulate for it, none survived the trials.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
200 / 100 unitsHow do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized ACE-031 (Ramatercept) keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Any bleeding disorder, or a personal or family history of unusual bleeding
- Development was halted, so it is not available and nobody is assessing anyone for it
Stop and get help
- Unusual nosebleeds
- Bleeding gums
- New spidery blood vessels appearing on the skin
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Nosebleeds and gum bleeding, which is why the trial was stopped
- Small dilated blood vessels visible in the skin
- The mechanism also blocks proteins that keep blood vessels stable, so this was a design problem rather than a dosing one
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is ACE-031 (Ramatercept) approved?
And where the numbers on this page come from.No. Not FDA-approved.
Sold for research use only. Not cleared for human consumption or medical use.
- DoseFrom research and community reports. No regulator has reviewed this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Reviewed22 July 2026
What else is like ACE-031 (Ramatercept)?
Others in Muscle building, side by side.If you're weighing ACE-031 (Ramatercept), it's worth reading Bimagrumab, Ipamorelin + CJC-1295 blend, and IGF-1 LR3 in the same class.
An experimental muscle-builder whose development was paused over side effects.
- Dose
- Trial doses
- How often
- Cycled
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- Dose
- 10 up to 30 mg/kg per month (trial doses)
- How often
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- Dose
- ~100 mcg CJC + 200-300 mcg ipa
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A powerful muscle-builder that also drops blood sugar hard.
- Dose
- 0.02 up to 0.05 mg per day (start low, increase slowly)
- How often
- Daily, cycled
10What these words mean
Show glossary +
What these words mean
- Titrate
- Starting at a low dose and increasing it slowly over time so your body adjusts and side effects stay mild.
- Subcutaneous
- An injection just under the skin, into the fat layer, usually with a short, thin insulin needle.
- Intramuscular (IM)
- An injection into a muscle, using a longer needle.
- Reconstitution
- Mixing a powdered peptide with liquid (bacteriostatic water) so it can be drawn into a syringe.
- Bacteriostatic water
- Sterile water with a tiny amount of preservative, used to mix powdered peptides.
- Concentration
- How strong the mixed peptide is, in milligrams per milliliter (mg/mL). More water makes it weaker; less water makes it stronger.
- Units (on the syringe)
- The marks on an insulin syringe. 100 units equals 1 mL. They measure how much liquid you draw, not the dose in milligrams.
- mcg and mg
- Units of dose. 1 milligram (mg) equals 1,000 micrograms (mcg).
- GLP-1
- A natural gut hormone that lowers appetite and blood sugar. Drugs that copy it, like semaglutide, are used for weight loss.
- Growth hormone secretagogue
- A compound that nudges your body to release more of its own growth hormone, rather than injecting the hormone itself.
- Half-life
- How long a compound stays active in your body. A longer half-life means you inject less often.
- Peptide vs small molecule
- A peptide is a short chain of amino acids. A few items here (like MK-677 or methylene blue) are small molecules, not true peptides, but people use them the same way.
- Research only
- No approved dose or use in people. Sold for research and not reviewed by the FDA for safety or quality.
- Investigational
- Still being tested in clinical trials and not yet approved or legally sold for general use.
- Banned in drug-tested sport
- Prohibited by the World Anti-Doping Agency (WADA); using it can disqualify a competing athlete.
Last reviewed 22 July 2026