ACE-031 (Ramatercept)_Dosage, benefits & legal status
Also known as ramatercept, ACE-031
An experimental muscle-builder whose development was paused over side effects.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is ACE-031 (Ramatercept)?
Plain language first. The technical label stays, but it never stands alone.Overview
By mopping up those brakes it lets muscle grow, but its development was paused over side effects.
ACE-031 (ramatercept) is a decoy receptor that soaks up myostatin and activin, the signals that limit muscle.
What it's used for
An experimental muscle-builder that soaks up the natural brakes on muscle, producing big gains in studies.
How does ACE-031 (Ramatercept) work?
What it does in the body, and where.ACE-031 is a decoy: a piece of the receptor that myostatin binds to, floating free in the blood so myostatin binds it instead of muscle.
- 01It soaks up myostatin and activinBoth signals that limit muscle growth, intercepted before they reach the receptor.
- 02Muscle grew in trialsIt reached phase 2 in Duchenne muscular dystrophy and did increase muscle mass.
- 03Development was stopped over blood vessel effectsNosebleeds, gum bleeding, and small dilated vessels in the skin. Activin signaling turns out to matter for blood vessels as well as muscle.
- 04It is here for referenceThis is a discontinued drug, not an option.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Muscle growth by soaking up the signals that limit itResearch only
- Duchenne muscular dystrophy, where the trial was halted in 2011 over bleeding side effectsInvestigational
The published record
Papers and trials about ACE-031 (Ramatercept)
Searched: ACE-031, ramatercept.
14 papers tagged human · 10 not reviews or lab · 2 clinical trial publications
4 registered trials · 1 with posted results
Furthest stage reached: Phase 2, results posted
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Prohibited at all times, in and out of competition. S4.3 Agents preventing activin receptor IIB activation: decoy activin receptors (e.g. ACE-031). Non-Specified.RegulatorsCounted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about ACE-031 (Ramatercept)
How much, and do you cycle it?
The range, and whether you take breaks.0.02 up to 3 mg/kg per dose, single dose in the trial. No schedule exists. Development was halted Trial dose
Stopped in 2013 during phase 2 in Duchenne muscular dystrophy after nosebleeds and small vessel changes appeared. Whatever schedules circulate for it, none survived the trials.
Nothing publishedNo figure
No disclosed human half-life. The development program was halted and the data was never published.
You can compare this against the whole library to see where it sits.
How is it given?
Dosing context and source notes.Dosed by body weight, not as a flat amount. The phase 1 study gave one injection under the skin at 0.02 up to 3 mg per kg in 48 healthy postmenopausal women. Lean mass rose 3.3 percent at 3 mg per kg by day 29. Body-weight dose. The calculator has no body-weight input, so it cannot produce a draw for this compound.
ACE-031 (Ramatercept) starts at $29.99 across 19 vendors, typically $36.20 – $173.00 per mg.
21 listings, last read Oct 24, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized ACE-031 (Ramatercept) keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Any bleeding disorder, or a personal or family history of unusual bleeding
- Development was halted, so it is not available and nobody is assessing anyone for it
Stop and get help
- Unusual nosebleeds
- Bleeding gums
- New spidery blood vessels appearing on the skin
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Nosebleeds and gum bleeding, which is why the trial was stopped
- Small dilated blood vessels visible in the skin
- The mechanism also blocks proteins that keep blood vessels stable, so this was a design problem rather than a dosing one
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is ACE-031 (Ramatercept) approved?
And where the numbers on this page come from.No. ACE-031 (Ramatercept) is not approved for any use, anywhere. It is sold labeled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin (subcutaneous)
- Checked22 September 2026
- DoseFrom published clinical trials. Not approved by a regulator for this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesNone traced yet.
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
What regulators say
From official documentsProhibited at all times, in and out of competition. S4.3 Agents preventing activin receptor IIB activation: decoy activin receptors (e.g. ACE-031). Non-Specified.
Checked 12 September 2026WADA: The 2026 Prohibited List (in force 1 January 2026)
You can compare this against the whole library, or read how to check a seller.
What else is like ACE-031 (Ramatercept)?
Others in Muscle building, side by side.If you're weighing ACE-031 (Ramatercept), it's worth reading IGF-1 DES, FLGR242, and GDF-8 (Myostatin) in the same class.
An experimental muscle-builder whose development was paused over side effects.
- Dose
- 0.02 up to 3 mg/kg per dose
- How often
- Single dose in the trial
A short-acting muscle-builder that works right where you inject it.
- Dose
- 0.05 up to 0.15 mg per dose (start low, increase slowly)
- How often
- Around training
Sold as an upgraded follistatin. Nobody outside the sellers has said what is in the vial.
- Dose
- No established dose
- How often
- No established schedule
The protein that limits muscle growth, which is the opposite of what most buyers want.
- Dose
- Research only
- How often
- Varies
Compared with
ACE-031 built muscle but was stopped for vascular side effects. Follistatin protein has not been tested by injection in people.
Read comparison →Not two alternatives: ACE-031 is a drug built to neutralise GDF-8, the protein better known as myostatin. One has human trial data; the other is the brake itself.
Read comparison →Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence
Beyond these, 17 records are indexed. Browse the records