How much water do I add to Petrelintide?

You can reconstitute Petrelintide with 0.5, 1, or 2 mL of bacteriostatic water. Each option produces a different concentration and syringe draw for the same dose. Use the calculator to see which is easiest to measure.

What does Petrelintide cost per dose?

Cost per dose depends on vial size, price paid, and your dose. Enter your vendor's price in the Petrelintide calculator to see cost per dose and monthly cost.

What is the reference dose for Petrelintide?

The commonly referenced range is 0.6 up to 9 mg per week (start low, increase slowly), taken weekly. This is reference information, not a recommendation. Talk to a licensed clinician.

What are the side effects of Petrelintide?

Reported side effects of Petrelintide include: Stomach side effects.; Trial-only.. Severity and frequency vary by person and dose.

Who should not take Petrelintide?

Petrelintide is generally not appropriate for: Pregnancy or breastfeeding; Any prescription medicine you take regularly, without checking for interactions first; Anyone who wants established safety data, because none exists for this compound in humans. Talk to a licensed clinician before starting.

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Decoding

Petrelintide_Dosage, benefits & legal status

Also known as ZP8396

By the Peptide Decoding Editorial Team

Published July 22, 2026 · Updated July 25, 2026

An experimental weekly fullness-hormone shot for weight loss.

Weight lossAmylin analogInvestigational

InAmylin analogs

Common vial size10 mg

Dose0.6 up to 9 mg per week (start low, increase slowly)

FrequencyWeekly

RouteUnder the skin (subcutaneous)

StatusInvestigational

MixYour choice, calculate it

CycledNot cycled in the trials

Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.

What is Petrelintide?

Plain language first. The technical label stays, but it never stands alone.

Overview

It copies the fullness hormone your pancreas makes, to reduce appetite. It is positioned as a gentler weight-loss option on its own. It is still experimental.

The technical version

Petrelintide is a long-acting amylin analog.

What it's used for

An experimental weekly shot that copies a natural fullness hormone to reduce appetite, positioned as a gentler standalone option.

How does Petrelintide work?

What it does in the body, and where.

Petrelintide is a long-acting amylin copy positioned as a standalone weight-loss drug rather than an add-on to a GLP-1.

01
It works through amylin receptors
Fullness signalled through the brainstem rather than the gut-hormone route.
02
Positioned on tolerability rather than maximum loss
The pitch is fewer gut side effects than GLP-1 drugs, at some cost in weight lost. Whether that trade holds up is what the trials are testing.
03
Still investigational
Phase 2 is ongoing. No approval anywhere.

Receptors

Acts on one receptor.

What else is it used for?

Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.

Weight loss, positioned as a gentler standalone option than the GLP-1 drugsInvestigational

The published record

Research index

Records indexed for Petrelintide

14 in humans, 3 of them original studies.

9 registered trials, 0 with posted results.

Browse the records

In animalsPro

In the labPro

ReviewsPro

Senior author sharePro

Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 11 September 2026.

Compound field notes

At a glance

Four things to know about Petrelintide

Evidence

Investigational

How much, and do you cycle it?

The range, and whether you take breaks.

0.6 up to 9 mg per week (start low, increase slowly), weekly. Not cycled in the trialsTrial dose

Given continuously for the whole study period: ZUPREME-1, 42 weeks. The dose is stepped up at the start, which is a ramp rather than a cycle, and no trial in this class built in a planned break.

Compare this against the whole library →

How long does it stay in the body?

The half-life, and where the figure comes from.

About 10 daysTrial protocol

Source: Braendholt Olsen, et al. Diabetes Obes Metab 2026, DOI 10.1111/dom.70753. ADA 2023 abstract 92-LB

You can compare this against the whole library to see where it sits.

How do I dose and price it?

Enter your vial and your dose. Pick a mix. We show the draw and the cost.

The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.

Your vial size (mg)

Printed on the vial.

What you paid per vial

Used for cost per dose only.

Your dose (mg)

Commonly referenced range: 0.6 up to 9 mg per week (start low, increase slowly)Trial dose

Choose your mix

0.5 mL water3units · 20 mg/mL

Half a 100-unit syringe

1 mL water6units · 10 mg/mL

One full 100-unit syringe

Easiest

2 mL water12units · 5 mg/mL

Two full 100-unit syringes

your own mL

units · —

Enter your own volume

Measuring the water1 mL = one full 100-unit syringe.

Your draw

12 / 100 units

Full calculator with reorder date →Read a syringe →

How do you store it?

Before mixing, and after.

Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.

Unmixed lyophilized Petrelintide keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.

What are the side effects and cautions?

Known cautions and warnings for this compound.

Who should avoid it

Check these before anything else.

Pregnancy or breastfeeding
Any prescription medicine you take regularly, without checking for interactions first
Anyone who wants established safety data, because none exists for this compound in humans

Stop and get help

These are emergencies. Seek care.

Spreading hives, swelling of the face or throat, or trouble breathing, which can happen with any injection and is a medical emergency
Redness, heat, or pus at the injection site, which can signal infection
Any severe or unexpected symptom
Anything unusual, since there is no known safety profile to compare it against

Common effects

Expected, and usually mild.

Stomach side effects.
Trial-only.
Redness, soreness, or a small bump at the injection site
Beyond the above, unknown. There is no reliable human data on what this compound commonly causes

Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.

Is Petrelintide approved?

And where the numbers on this page come from.

No. Petrelintide is not approved anywhere and is currently in company-run clinical trials. There is no legal route to obtain it outside a trial.

Approval status
Investigational
Route
Under the skin (subcutaneous)
Checked
September 2026

What has happened recently

Still in trials. Early data suggests it is easier on the stomach than the GLP-1 drugs, but it is not approved and long-term safety is unknown.

You can compare this against the whole library, or read how to check a seller.

DoseFrom published clinical trials. Not approved by a regulator for this dose.
Vial sizeFrom what vendors typically list; not a recommendation.
Sources
Zealand Pharma, positive phase 2 ZUPREME-1 results for petrelintide Zealand Pharma phase 2 announcement, withdrawal and tolerability detail
Reviewed8 September 2026

What else is like Petrelintide?

Others in Amylin analogs, side by side.

If you're weighing Petrelintide, it's worth reading Eloralintide, Cagrilintide, and Amycretin in the same class.

YOU ARE HERE

PETRE36 residues

Petrelintide

An experimental weekly fullness-hormone shot for weight loss.

Investigational

Dose: 0.6 up to 9 mg per week (start low, increase slowly)
How often: Weekly

ELORA

Eloralintide

An experimental weekly fullness-hormone shot for weight loss.

Investigational

Dose: 1 up to 9 mg per week (trial doses)
How often: Weekly

CAGRI

Cagrilintide

A weekly fullness-hormone shot, often paired with semaglutide for bigger loss.

Investigational

Dose: 0.3 up to 4.5 mg per dose (start low, increase slowly)
How often: Weekly

AMY

Amycretin

An experimental two-in-one weight-loss compound, as a pill or a shot.

Investigational

Dose: 0.3 up to 60 mg per week (start low, increase slowly)
How often: Weekly/daily

How Petrelintide stacks up against other amylins

Guides for this compound

How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.

Sources

Zealand Pharma, positive phase 2 ZUPREME-1 results for petrelintide(2026)
493 participants, mean baseline BMI 37. Up to 10.7 percent mean weight reduction at week 42 against 1.7 percent on placebo. At the maximally effective dose there were no cases of vomiting and no discontinuations for gastrointestinal adverse events.
Zealand Pharma phase 2 announcement, withdrawal and tolerability detail(2026)
Withdrawal for any reason was 8.4 percent across petrelintide arms against 13.6 percent on placebo. The company also notes female participants lost considerably more weight than male participants in this trial.

Last reviewed 8 September 2026

Beyond these, 16 records are indexed. Browse the records