Mazdutide_Dosage, benefits & legal status
Also known as LY3305677, IBI362
An experimental weekly weight-loss shot (approved in China) that also helps blood sugar and cholesterol.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Mazdutide?
Plain language first. The technical label stays, but it never stands alone.Overview
It works on appetite and metabolism at once for weight loss and better blood sugar. It is approved in China and still in trials elsewhere.
Mazdutide is a dual GLP-1 and glucagon agonist, similar in design to survodutide.
What it's used for
An experimental weekly weight-loss shot (approved in China) that also improves blood sugar, cholesterol, and uric acid.
How does Mazdutide work?
What it does in the body, and where.Mazdutide is the same GLP-1 plus glucagon combination as survodutide, developed separately and furthest along in China.
- 01Two hormones, intake and expenditureAppetite falls through GLP-1 while glucagon nudges the body to burn more.
- 02Approved in China, in trials elsewhereIts regulatory position differs by country, which is unusual in this class and worth checking against where you are.
Hits 2 receptors at once.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Long-term weight management, which is its approved use in ChinaClinical use
- Blood sugar control in type 2 diabetes, also approved in ChinaClinical use
- Improving cholesterol and uric acid levelsEarly research
The published record
101
Records indexed for Mazdutide
79 in humans, 14 of them original studies.
43 registered trials, 1 with posted results.
Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 12 September 2026.
At a glance
Four things to know about Mazdutide
Evidence
Investigational
Category
Weight loss and metabolic
Common vial
10 mg
Half-life
7 to 45 days, dose dependent
How much, and do you cycle it?
The range, and whether you take breaks.2 up to 9 mg per dose (start low, increase slowly), weekly. Not cycled in the trialsTrial dose
Given continuously for the whole study period: GLORY-1, 48 weeks. The dose is stepped up at the start, which is a ramp rather than a cycle, and no trial in this class built in a planned break.
How long does it stay in the body?
The half-life, and where the figure comes from.7 to 45 days, dose dependentTrial protocol
The range is wide because the half-life rises with dose. The 60 to 100 hours quoted on vendor sites appears to come from monkey data rather than human.
Source: Phase 1b, PMC9561728. Phase 3 programme, NEJM 2025, NEJMoa2411528
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
40 / 100 unitsMazdutide starts at $66.43 across 7 vendors, typically $6.64 – $8.00 per mg.
8 listings, last read Sep 5, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Mazdutide keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- A personal or family history of medullary thyroid cancer, or MEN 2
- Pregnancy
Stop and get help
- Severe stomach pain that spreads to your back
- A lump or swelling in your neck, hoarseness, or trouble swallowing
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Nausea, diarrhea, and vomiting, mostly mild to moderate during dose increases
- Only about 3% stopped the trial because of side effects
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Mazdutide approved?
And where the numbers on this page come from.No. Mazdutide is not approved anywhere and is currently in company-run clinical trials. There is no legal route to obtain it outside a trial. It is approved in China, but not in the United States.
- Approval statusInvestigational
- RouteUnder the skin (subcutaneous)
- CheckedAugust 2026
- Approved outside the USChina: Approved by China's regulator in 2025 for weight management, later for type 2 diabetes.This does not change the United States position above.
What has happened recently
Approved by China's regulator in 2025 for weight management and later for type 2 diabetes. It is NOT FDA-approved. The FDA has issued a warning letter to a US peptide vendor selling it, since 'research use only' labelling does not make it legal for human use.
You can compare this against the whole library, or read how to check a seller.
- DoseFrom published clinical trials. Not approved by a regulator for this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
- Reviewed14 August 2026
What else is like Mazdutide?
Others in GLP-1 agonists, side by side.If you're weighing Mazdutide, it's worth reading Amycretin, VK2735, and Orforglipron in the same class.
An experimental weekly weight-loss shot (approved in China) that also helps blood sugar and cholesterol.
- Dose
- 2 up to 9 mg per dose (start low, increase slowly)
- How often
- Weekly
An experimental two-in-one weight-loss compound, as a pill or a shot.
- Dose
- 0.3 up to 60 mg per week (start low, increase slowly)
- How often
- Weekly/daily
An experimental weight-loss compound in the tirzepatide family, as a shot or pill.
- Dose
- 2.5 up to 15 mg per week (start low, increase slowly)
- How often
- Weekly
The first GLP-1 weight-loss pill, approved in 2026 and taken any time of day.
- Dose
- 0.8 up to 17.2 mg per day (six steps, 30 days apart)
- How often
- Daily
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
- Innovent Biologics, NMPA approval announcements for mazdutide(2025)Approved in China for chronic weight management in June 2025 and for glycaemic control in type 2 diabetes in September 2025. Not approved anywhere else.
Last reviewed 14 August 2026
Beyond these, 101 records are indexed. Browse the records