Survodutide_Dosage, benefits & legal status
Also known as BI 456906, Survodexide
An experimental weekly shot for weight loss and fatty-liver disease.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Survodutide?
Plain language first. The technical label stays, but it never stands alone.Overview
It copies your fullness signal and also nudges your metabolism to burn more energy, which is why trials show strong weight loss and better fatty liver. It is still experimental.
Survodutide is a dual GLP-1 and glucagon agonist.
What it's used for
An experimental weekly shot for weight loss and fatty-liver disease, with strong early results. It works on two metabolism pathways.
How does Survodutide work?
What it does in the body, and where.Survodutide pairs GLP-1 with glucagon. Glucagon is the counterintuitive half: it is the hormone that raises blood sugar, and using it deliberately for weight loss took a while to make sense to people.
- 01GLP-1 reduces what you take inThe familiar half: slower stomach emptying, quieter appetite.
- 02Glucagon raises what you spendIt pushes the liver and fat tissue to release and burn stored fuel, so energy leaves the body as well as arriving less.
- 03Fatty liver improved alongside the weightThe phase 2 trial in liver disease was the notable result, not the weight figure, and it is what the drug is being developed around.
Hits 2 receptors at once.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Weight lossInvestigational
- Fatty liver disease (MASH)Investigational
- Type 2 diabetesInvestigational
The published record
117
Records indexed for Survodutide
83 in humans, 22 of them original studies.
33 registered trials, 3 with posted results.
Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 12 September 2026.
At a glance
Four things to know about Survodutide
Evidence
Investigational
Category
Weight loss and metabolic
Common vial
10 mg
Half-life
About 6 days
How much, and do you cycle it?
The range, and whether you take breaks.2.4 up to 6 mg per week (start low, increase slowly), weekly. Not cycled in the trialsTrial dose
Given continuously for the whole study period: SYNCHRONIZE-1 and -2, 76 weeks. The dose is stepped up at the start, which is a ramp rather than a cycle, and no trial in this class built in a planned break.
How long does it stay in the body?
The half-life, and where the figure comes from.About 6 daysTrial protocol
Not yet traced to a primary source.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
48 / 100 unitsSurvodutide starts at $73.89 across 9 vendors, typically $7.39 – $15.00 per mg.
10 listings, last read Sep 5, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Survodutide keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- No formal contraindications established, since it is still investigational
- Pregnancy
Stop and get help
- Vomiting badly enough that you cannot keep fluids down
- Severe stomach pain that spreads to your back
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Nausea in about two thirds of trial participants
- Diarrhea in about half, vomiting in about four in ten
- About 20% stopped the trial because of side effects, mostly stomach-related
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Survodutide approved?
And where the numbers on this page come from.No. Survodutide is not approved anywhere and is currently in company-run clinical trials. There is no legal route to obtain it outside a trial.
- Approval statusInvestigational
- RouteUnder the skin (subcutaneous)
- CheckedSeptember 2026
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
You can compare this against the whole library, or read how to check a seller.
- DoseFrom published clinical trials. Not approved by a regulator for this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
- Reviewed8 September 2026
What else is like Survodutide?
Others in GLP-1 agonists, side by side.If you're weighing Survodutide, it's worth reading Mazdutide, Amycretin, and VK2735 in the same class.
An experimental weekly shot for weight loss and fatty-liver disease.
- Dose
- 2.4 up to 6 mg per week (start low, increase slowly)
- How often
- Weekly
An experimental weekly weight-loss shot (approved in China) that also helps blood sugar and cholesterol.
- Dose
- 2 up to 9 mg per dose (start low, increase slowly)
- How often
- Weekly
An experimental two-in-one weight-loss compound, as a pill or a shot.
- Dose
- 0.3 up to 60 mg per week (start low, increase slowly)
- How often
- Weekly/daily
An experimental weight-loss compound in the tirzepatide family, as a shot or pill.
- Dose
- 2.5 up to 15 mg per week (start low, increase slowly)
- How often
- Weekly
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
- le Roux et al., glucagon and GLP-1 receptor dual agonist survodutide for obesity, Lancet Diabetes and Endocrinology(2024)Randomised, double-blind, placebo-controlled dose-finding phase 2 trial over 46 weeks. Mean weight change by planned treatment was -6.2 percent at 0.6 mg, -12.5 percent at 2.4 mg, -13.2 percent at 3.6 mg, against -2.8 percent on placebo.
- Survodutide phase 2 dose-finding trial, completion and tolerability detail(2024)Only 233 of 386 participants, 60.4 percent, completed the 46-week treatment period. Adverse events occurred in 91 percent on survodutide against 75 percent on placebo, mostly gastrointestinal.
Last reviewed 8 September 2026
Beyond these, 117 records are indexed. Browse the records