Tesofensine_
Also known as NS2330
An experimental appetite-suppressing pill with strong weight-loss numbers.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Tesofensine?
Plain language first. The technical label stays, but it never stands alone.Overview
Tesofensine is a small molecule, not a peptide, that blocks the reuptake of three brain chemicals: dopamine, noradrenaline, and serotonin. In plain terms: it acts on the brain's appetite and reward system like a stimulant to suppress hunger, which also means more heart-related risk.
What it's used for
An experimental appetite-suppressing pill with strong weight-loss numbers.
How does Tesofensine work?
What it does in the body, and where.Tesofensine is a stimulant-class small molecule, not a peptide. It was originally developed for Parkinson's disease, and the weight loss was noticed as a side effect.
- 01It blocks reuptake of dopamine, noradrenaline and serotoninKeeping all three circulating longer in the brain, which suppresses appetite.
- 02Appetite falls, and so does the reward from eatingThis works on the wanting rather than on fullness, which is a different mechanism from everything else in this category.
- 03Blood pressure and heart rate riseThe predictable cost of a triple reuptake inhibitor, and the reason its regulatory path has been difficult.
A schematic of the compound's mechanism, not a diagnostic image.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Appetite suppression and weight lossInvestigational
- Parkinson's and Alzheimer's disease, which is what it was originally developed for before those trials failedInvestigational
How much, and do you cycle it?
The range, and whether you take breaks.0.25 up to 0.5 mg per day, daily. Continuous daily dosing, studied to 24 weeksHuman study
Given daily without breaks in the trials. The phase 2 study ran 24 weeks at up to 1 mg daily, with an extension to 48 weeks. No cycling was used or tested.
Source: Astrup et al., TIPO-1: 24 weeks daily tesofensine (Lancet 2008;372:1906-13)
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Tesofensine is not injected
It is taken by mouth (oral).
How do you store it?
Before mixing, and after.Room temperature. Cool, dry, out of light.
Tesofensine is taken as a pill or capsule. Keep it in its original container at room temperature, away from heat, humidity, and direct sun. No fridge or mixing needed. Check the expiration date on the bottle.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Uncontrolled high blood pressure
- Heart rhythm problems
- A history of psychiatric conditions
- Pregnancy
Stop and get help
- A racing or pounding heartbeat
- Severe agitation, panic, or a marked change in mood
- Chest discomfort
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Dry mouth and difficulty sleeping
- Constipation, diarrhea, and nausea
- A rise in blood pressure and heart rate, which is the main safety concern
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Tesofensine approved?
And where the numbers on this page come from.No. Not FDA-approved.
It is still being studied; a regulator has not cleared it for this use.
- DoseFrom published clinical trials. Not approved by a regulator for this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Reviewed22 July 2026
What else is like Tesofensine?
Others in Weight loss and metabolic, side by side.If you're weighing Tesofensine, it's worth reading Semaglutide, Tirzepatide, and Retatrutide in the same class.
An experimental appetite-suppressing pill with strong weight-loss numbers.
- Dose
- 0.25 up to 0.5 mg per day
- How often
- Daily
The drug in Ozempic and Wegovy: a weekly shot that curbs hunger for steady weight loss.
- Dose
- 0.25 up to 2.4 mg per week (start low, increase slowly)
- How often
- Weekly
The drug in Mounjaro and Zepbound: a weekly shot for major weight loss and blood sugar.
- Dose
- 2.5 up to 15 mg per week (start low, increase slowly)
- How often
- Weekly
An experimental weekly shot with some of the biggest weight-loss numbers yet in trials.
- Dose
- 1 up to 12 mg per dose (start low, increase slowly)
- How often
- Weekly
10What these words mean
Show glossary +
What these words mean
- Titrate
- Starting at a low dose and increasing it slowly over time so your body adjusts and side effects stay mild.
- Subcutaneous
- An injection just under the skin, into the fat layer, usually with a short, thin insulin needle.
- Intramuscular (IM)
- An injection into a muscle, using a longer needle.
- Reconstitution
- Mixing a powdered peptide with liquid (bacteriostatic water) so it can be drawn into a syringe.
- Bacteriostatic water
- Sterile water with a tiny amount of preservative, used to mix powdered peptides.
- Concentration
- How strong the mixed peptide is, in milligrams per milliliter (mg/mL). More water makes it weaker; less water makes it stronger.
- Units (on the syringe)
- The marks on an insulin syringe. 100 units equals 1 mL. They measure how much liquid you draw, not the dose in milligrams.
- mcg and mg
- Units of dose. 1 milligram (mg) equals 1,000 micrograms (mcg).
- GLP-1
- A natural gut hormone that lowers appetite and blood sugar. Drugs that copy it, like semaglutide, are used for weight loss.
- Growth hormone secretagogue
- A compound that nudges your body to release more of its own growth hormone, rather than injecting the hormone itself.
- Half-life
- How long a compound stays active in your body. A longer half-life means you inject less often.
- Peptide vs small molecule
- A peptide is a short chain of amino acids. A few items here (like MK-677 or methylene blue) are small molecules, not true peptides, but people use them the same way.
- Research only
- No approved dose or use in people. Sold for research and not reviewed by the FDA for safety or quality.
- Investigational
- Still being tested in clinical trials and not yet approved or legally sold for general use.
- Banned in drug-tested sport
- Prohibited by the World Anti-Doping Agency (WADA); using it can disqualify a competing athlete.
Last reviewed 22 July 2026