Tesofensine_Dosage, benefits & legal status
Also known as NS2330
An experimental appetite-suppressing pill with strong weight-loss numbers.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Tesofensine?
Plain language first. The technical label stays, but it never stands alone.Overview
It acts on the brain's appetite and reward system like a stimulant, to suppress hunger. That also means more risk to the heart.
Tesofensine is a small molecule, not a peptide, that blocks the reuptake of three brain chemicals: dopamine, noradrenaline, and serotonin.
What it's used for
An experimental appetite-suppressing pill with strong weight-loss numbers.
How does Tesofensine work?
What it does in the body, and where.Tesofensine is a stimulant-class small molecule, not a peptide. It was originally developed for Parkinson's disease, and the weight loss was noticed as a side effect.
- 01It blocks reuptake of dopamine, noradrenaline and serotoninKeeping all three circulating longer in the brain, which suppresses appetite.
- 02Appetite falls, and so does the reward from eatingThis works on the wanting rather than on fullness, which is a different mechanism from everything else in this category.
- 03Blood pressure and heart rate riseThe predictable cost of a triple reuptake inhibitor, and the reason its regulatory path has been difficult.
A schematic of the compound's mechanism, not a diagnostic image.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Appetite suppression and weight lossInvestigational
- Parkinson's and Alzheimer's disease, which is what it was originally developed for before those trials failedInvestigational
The published record
Papers and trials about Tesofensine
Searched: tesofensine, NS2330.
51 papers tagged human · 23 not reviews or lab · 11 clinical trial publications
14 registered trials · 5 with posted results
Furthest stage reached: Phase 2, results posted
Compare this against the whole library →
Prohibited in competition. S6.B Specified stimulants (tesofensine named).RegulatorsCounted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about Tesofensine
Evidence
Investigational
Category
Weight loss and metabolic
Common vial
0.5 mg
Half-life
About 9 days
How much, and do you cycle it?
The range, and whether you take breaks.0.25 up to 0.5 mg per day, daily. Continuous daily dosing, studied to 24 weeks Human study
Given daily without breaks in the trials. The phase 2 study ran 24 weeks at up to 1 mg daily, with an extension to 48 weeks. No cycling was used or tested.
Source: Astrup et al., TIPO-1: 24 weeks daily tesofensine (Lancet 2008;372:1906-13)
About 9 daysTrial protocol
An active metabolite lasts far longer, around 16 days, so the compound keeps working well past the parent figure.
Source: Saniona clinical protocol NCT03488719. Bara-Jimenez W, et al. Mov Disord 2004;19(10):1183-6
You can compare this against the whole library to see where it sits.
What does it cost?
Typical dose and cost, in plain numbers.The products priced here are not injected
The listed products are taken by mouth (oral).
Tesofensine starts at $50.00 across 43 vendors, typically $397.90 per mg.
59 listings, last read Oct 24, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Room temperature. Cool, dry, out of light.
Tesofensine is taken as a pill or capsule. Keep it in its original container at room temperature, away from heat, humidity, and direct sun. No fridge or mixing needed. Check the expiration date on the bottle.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Uncontrolled high blood pressure
- Heart rhythm problems
- A history of psychiatric conditions
- Pregnancy
Stop and get help
- A racing or pounding heartbeat
- Severe agitation, panic, or a marked change in mood
- Chest discomfort
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Dry mouth and difficulty sleeping
- Constipation, diarrhea, and nausea
- A rise in blood pressure and heart rate, which is the main safety concern
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Tesofensine approved?
And where the numbers on this page come from.No. Tesofensine is not approved anywhere and is currently in company-run clinical trials. There is no legal route to obtain it outside a trial.
- Approval statusInvestigational
- RouteBy mouth (oral)
- Checked22 July 2026
- DoseFrom published human studies. Not approved by a regulator for this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesNone traced yet.
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
What regulators say
From official documentsProhibited in competition. S6.B Specified stimulants (tesofensine named).
Checked 12 September 2026WADA: The 2026 Prohibited List (in force 1 January 2026)
You can compare this against the whole library, or read how to check a seller.
If you're weighing Tesofensine, it's worth reading HGH Fragment 176-191, Lipo-C (MIC blend), and Adipotide in the same class.
An experimental appetite-suppressing pill with strong weight-loss numbers.
- Dose
- 0.25 up to 0.5 mg per day
- How often
- Daily
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- Dose
- 0.25 up to 0.5 mg per day (start low, increase slowly)
- How often
- Daily
A compounded fat-loss shot with no fixed formula and no approved version.
- Dose
- No standard dose. The formula changes between pharmacies
- How often
- Usually weekly
An experimental fat-loss peptide considered dangerous, with no safe human use.
- Dose
- 0.03 mg/kg per day
- How often
- Daily for 28 days in the trial
Guides for this compound
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
- Semaglutide vs Tirzepatide vs Retatrutide
One receptor, two, or three. Mechanism, trial weight loss, side effects, and real cost.
Sources
No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence
Beyond these, 69 records are indexed. Browse the records