MGF (Mechano Growth Factor)_Dosage, benefits & legal status
Also known as mechano growth factor, IGF-1Ec, MGF
A local muscle-repair peptide injected near a worked muscle.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is MGF (Mechano Growth Factor)?
Plain language first. The technical label stays, but it never stands alone.Overview
It activates the stem cells that rebuild muscle, so it is injected near a worked muscle to speed repair.
MGF (mechano growth factor) is a variant of IGF-1 that muscles produce locally after intense exercise.
What it's used for
A local muscle-repair peptide that helps rebuild muscle after hard training, injected near the worked muscle.
How does MGF (Mechano Growth Factor) work?
What it does in the body, and where.MGF is a variant of IGF-1 that your muscles produce themselves after hard training. It is a repair signal, not a growth hormone.
- 01Muscle makes it in response to mechanical stressHence the name: mechano growth factor.
- 02It activates satellite cellsThe stem cells that sit alongside muscle fibres and are recruited to rebuild them after damage.
- 03It clears within minutesWhich is why it is injected close to the muscle worked, and why the pegylated version exists.
- 04Human evidence is essentially absentThe physiology is established. Injecting it as a supplement is not studied.
Where this compound is thought to act.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Repairing muscle after hard training, injected near the worked muscleResearch only
The published record
377
Records indexed for MGF (Mechano Growth Factor)271 papers and 100 trials indexed in detail.
238 in humans, 81 of them original studies.
106 registered trials, 31 with posted results among the 100 indexed.
FDA: Category 3.
Counted from Europe PMC indexing, not read by a person. Human means indexed under humans, which includes reviews and work on human cells. Original studies exclude reviews and lab work on human cells.Last updated 12 September 2026.
At a glance
Four things to know about MGF (Mechano Growth Factor)
Evidence
Research only
Category
Muscle building
Common vial
2 mg
Half-life
About 5 to 7 minutes
How much, and do you cycle it?
The range, and whether you take breaks.0.1 up to 0.2 mg per dose (start low, increase slowly), post-workout. No established scheduleNo range
No published study has established how long to take this or whether a break is needed. Schedules quoted online come from vendors and forums, and different sources disagree.
How long does it stay in the body?
The half-life, and where the figure comes from.About 5 to 7 minutesAnimal study
An estimate based on how fast the peptide breaks down rather than a measurement in a person. No human study exists.
Not yet traced to a primary source.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
10 / 100 unitsMGF (Mechano Growth Factor) starts at $20.00 across 12 vendors, typically $11.63 – $32.50 per mg.
17 listings, last read Sep 6, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized MGF (Mechano Growth Factor) keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- No human safety data exists, so nobody can say who should avoid it
- Pregnancy
- Active cancer, as a precaution given the growth mechanism
Stop and get help
- Anything unusual, since there is no known safety profile to compare against
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Unknown in humans. This compound has only been studied in cells and animals
What regulators say
- FDA: Bulk Drug Substances Nominated for Use in Compounding Under Section 503A (interim categories 1, 2, 3), updated May 14, 2026Category 3
Listed as Mechano growth factor (MGF)
Checked 11 September 2026
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is MGF (Mechano Growth Factor) approved?
And where the numbers on this page come from.No. MGF (Mechano Growth Factor) is not approved for any use, anywhere. It is sold labelled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin or into muscle
- CheckedJuly 2026
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
Banned in drug-tested sport. Most research peptides are prohibited under WADA's S0 category, which covers any substance with no approval from any regulatory authority for human use. That means a compound can be banned without ever being named on the prohibited list. Check with your own anti-doping authority rather than assuming absence from the list means permitted.
You can compare this against the whole library, or read how to check a seller.
- DoseFrom research and community reports. No regulator has reviewed this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
- Reviewed22 July 2026
What else is like MGF (Mechano Growth Factor)?
Others in Muscle building, side by side.If you're weighing MGF (Mechano Growth Factor), it's worth reading PEG-MGF, ACE-031 (Ramatercept), and BPC-157 in the same class.
A local muscle-repair peptide injected near a worked muscle.
- Dose
- 0.1 up to 0.2 mg per dose (start low, increase slowly)
- How often
- Post-workout
A longer-lasting muscle-repair peptide on a less-frequent schedule.
- Dose
- 0.2 up to 0.4 mg per dose (start low, increase slowly)
- How often
- 1-2x per week
An experimental muscle-builder whose development was paused over side effects.
- Dose
- Trial doses
- How often
- Cycled
A popular healing peptide for injuries, gut, and joint or tendon pain.
- Dose
- 0.25 up to 0.5 mg per dose (start low, increase slowly)
- How often
- 1-2x daily
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
- FDA, Bulk drug substances nominated for use in compounding under section 503A, updated 14 May 2026(2026)Mechano growth factor appears on this list, in category 3, which FDA titles bulk drug substances nominated without adequate support. Read what that does and does not mean. Somebody asked FDA to allow MGF in compounded medicines, and the agency's position is that the nomination arrived without enough supporting information to evaluate it. That is not a safety finding: category 2 is the bucket for substances raising significant safety risks, and MGF is not in it. It is also not an endorsement, because category 1 is the bucket for substances actually under evaluation, and MGF is not in that one either. For context on the company MGF keeps here, GHRP-2 and GHRP-6 sit in the same category 3 list, while ibutamoren mesylate and kisspeptin-10 are the peptide-adjacent entries in category 2. The absence of a published trial remains true. What has changed is that a regulator has now said something on the record, which is worth more to a reader than an empty section.
Last reviewed 22 July 2026
Beyond these, 371 records are indexed. Browse the records