Peptide Decoding
New?New to peptides?Start here →
Decoding

Gonadorelin (GnRH)_Dosage, benefits & legal status

Also known as GnRH, LHRH, Factrel, Gonadorelin

Published July 22, 2026 · Updated August 14, 2026

A shot that keeps your own testosterone and fertility hormones going.

Hormone / fertilityGnRH peptideClinical use
InSexual and hormonal
Common vial size2 mg
Dose0.1 up to 0.2 mg per dose (start low, increase slowly)
Frequency2-3x per week or more
RouteUnder the skin (subcutaneous)
StatusPrescription/compounded
MixYour choice, open the Gonadorelin (GnRH) calculator
CycledPulsed, not continuous. How often you give it decides whether it switches the system on or off

Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.

See how this dose compares across the library →

01

What is Gonadorelin (GnRH)?

Plain language first. The technical label stays, but it never stands alone.

Overview

It prompts your own hormone production, often used alongside testosterone therapy to keep the testicles active. Because it clears fast, it needs frequent dosing.

The technical version

Gonadorelin is synthetic GnRH, the hormone your brain uses to tell the pituitary to make testosterone and fertility hormones.

What it's used for

A shot that tells the body to make its own testosterone and fertility hormones, often used alongside testosterone therapy to keep the testicles working.

02

How does Gonadorelin (GnRH) work?

What it does in the body, and where.

Gonadorelin is GnRH itself, identical to what your brain releases. How you give it determines whether it switches the system on or shuts it off.

  1. 01
    It prompts the pituitary to release LH and FSH
    Which in turn drive testosterone and sperm, or the ovarian cycle.
  2. 02
    Pulsed dosing stimulates, continuous dosing suppresses
    The pituitary desensitises to a constant signal. This is not a side effect but the basis of an entire drug class used to shut hormone production down deliberately.
  3. 03
    Timing therefore matters more than dose
    Which is why it is given as frequent small injections rather than a steady level.
  4. 04
    It clears in minutes
    A very short half-life, which is what makes pulsed dosing practical.
Anatomical illustration highlighting hormones
WHERE THIS COMPOUND IS THOUGHT TO ACT:
Pituitary

03

What else is it used for?

Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.

  • Testing whether the pituitary gland is working, which was its approved diagnostic useClinical use
  • Keeping the testicles working during testosterone therapy, which is the main reason it is used nowClinical use

The published record

Research index

1,513

Papers and trials about Gonadorelin (GnRH)

Searched: Gonadorelin, Factrel.

Left out: GnRH (too short to disambiguate without context); LHRH (too short to disambiguate without context).

220 papers tagged human · 89 not reviews or lab · 28 clinical trial publications

1,164 registered trials · 24 with posted results

Furthest stage reached: Approved in the US, no longer sold, Factrel, discontinued

Compare this against the whole library →

Category 1, component of an FDA-approved drugRegulators
Browse the records
In animals150
In the lab5
Reviews30
Senior author shareSpread across many groups

Evidence summary

Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count. 349 papers and 100 trials indexed in detail.

Gonadorelin (GnRH) vial rendering
Compound field notes

At a glance

Four things to know about Gonadorelin (GnRH)

01

Evidence

Clinical use

02

Category

Sexual and hormonal

03

Common vial

2 mg

04

Half-life

2 to 10 minutes

04

How much, and do you cycle it?

The range, and whether you take breaks.

0.1 up to 0.2 mg per dose (start low, increase slowly), 2-3x per week or more. Pulsed, not continuous. How often you give it decides whether it switches the system on or off Human study

This is the clearest cycling story in the whole set. Given in pulses roughly every one to two hours it stimulates the axis; given continuously it shuts the axis down. That is not a side effect, it is the mechanism, and it is what drugs like leuprolide exploit to suppress testosterone deliberately. Continuous dosing does the opposite of what most people taking it want.

Source: Belchetz et al., pulsatile vs continuous GnRH (Science 1978)

Compare this against the whole library →

05

How long does it stay in the body?

The half-life, and where the figure comes from.

2 to 10 minutesHuman study

Sources disagree. Human pharmacokinetic work behind the Factrel application gives 2 to 10 minutes, while other references give 10 to 40 minutes. The short half-life is the whole point of the molecule: pulsed dosing stimulates the pituitary and continuous dosing shuts it down.

Not yet traced to a primary source.

You can compare this against the whole library to see where it sits.

06

How do I dose and price it?

Enter your vial and your dose. Pick a mix. We show the draw and the cost.

The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.

Your vial size (mg)
Printed on the vial.
What you paid per vial
$
Used for cost per dose only.
Your dose (mcg)
Commonly referenced range: 100 up to 200 mcgClinical use

Choose your mix

your own mL
units · —
Enter your own volume

Measuring the water1 mL = one full 100-unit syringe.

YOUR DRAW10 / 100 units
Full calculator with reorder date →Read a syringe →
What it costs

Gonadorelin (GnRH) starts at $17.00 across 23 vendors, typically $6.55 – $20.00 per mg.

27 listings, last read Oct 24, 2026. Shipping and card fees are not included.

See all 27 listings →
07

How do you store it?

Before mixing, and after.

Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.

Unmixed lyophilized Gonadorelin (GnRH) keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.

08

What are the side effects and cautions?

Known cautions and warnings for this compound.

Solubility, computed: 30% charged residues, 30% hydrophobic. Water usually sufficient.

A first-pass rule from peptide manufacturers' guidance. It does not account for disulfide bridges, salt form or how the powder was dried, and it predicts what should be easy rather than what will happen in your vial.

Who should avoid it

Check these before anything else.
  • Known allergy to gonadorelin
  • Any condition where raising sex hormones would be unwise
  • Pregnancy or breastfeeding

Stop and get help

These are emergencies. Seek care.
  • Swelling, trouble breathing, or hives, since repeated use has caused severe allergic reactions

Common effects

Expected, and usually mild.
  • Headache and light-headedness
  • Nausea
  • Injection-site reactions
  • Generally mild after a single dose

Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.

09

Is Gonadorelin (GnRH) approved?

And where the numbers on this page come from.

Not approved, but legal to obtain. Gonadorelin (GnRH) has no FDA approval, and it can be prescribed or prepared by a compounding pharmacy in the United States.

  • Approval status
    Clinical use
  • Route
    Under the skin (subcutaneous)
  • Checked
    22 July 2026
  • Dose
    From product labeling and clinical guidelines.
  • Vial size
    From what vendors typically list; not a recommendation.
  • Sources
    None traced yet.

What has happened recently

We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.

What regulators say

From official documents

Enforcement naming this compound

  • Vendor product named as an unapproved new drug (Wholesale Peptide, June 2026)

    Research-use-only labelling did not change the finding This is a finding about one seller's vial, not about the compound or any approved product containing it.

    Read the letter

You can compare this against the whole library, or read how to check a seller.

10

What else is like Gonadorelin (GnRH)?

Others in Sexual and hormonal, side by side.

If you're weighing Gonadorelin (GnRH), it's worth reading Enclomiphene, HMG (Menotropin), and Triptorelin in the same class.

YOU ARE HERE
Gonadorelin (GnRH)

A shot that keeps your own testosterone and fertility hormones going.

Clinical use
Dose
0.1 up to 0.2 mg per dose (start low, increase slowly)
How often
2-3x per week or more
ENCLO
Enclomiphene

Half of the fertility drug Clomid, sold on its own for testosterone.

Clinical use
Dose
12.5 up to 25 mg per day
How often
Daily
HMG
HMG (Menotropin)

A fertility hormone shot that drives sperm or egg production.

Clinical use
Dose
75 up to 150 IU per dose (start low, increase slowly)
How often
Several per week
TRIPTORELIN
Triptorelin

An FDA-approved hormone drug for prostate cancer, sold by research vendors for something else entirely.

FDA-approved
Dose
Set by an FDA label
How often
Monthly to six-monthly depot
See other sexual and hormonal peptides

Compared with

Enclomiphene vs HCG vs Gonadorelin vs Kisspeptin

Three sit on one hormone chain and the fourth skips it. The one with the best trial evidence was rejected by the FDA in 2015 and abandoned.

Read comparison →

Guides for this compound

Sources

No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence

Beyond these, 449 records are indexed. Browse the records