Danuglipron_Dosage, benefits & legal status
Also known as PF-06882961
An experimental weight-loss pill whose development was stopped over a liver-injury signal.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Danuglipron?
Plain language first. The technical label stays, but it never stands alone.Overview
What it's used for
An experimental appetite-lowering pill for weight loss, no needles. It is in testing.
How does Danuglipron work?
What it does in the body, and where.Danuglipron was an attempt at an oral GLP-1 pill using a small molecule rather than a peptide. Development stopped.
- 01It activated the GLP-1 receptor as a small moleculeThe same approach that orforglipron went on to succeed with.
- 02Development was halted in April 2025Pfizer stopped the program after a participant showed signs of drug-induced liver injury, which resolved when the drug was withdrawn.
- 03It is here for reference, not as an optionThe dose figures on this page are historical. This is not something you can obtain or should be seeking.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Weight loss without injections. Development was discontinued in 2025, so nothing is approved or availableResearch only
The published record
Papers and trials about Danuglipron
Searched: Danuglipron, PF-06882961.
55 papers tagged human · 26 not reviews or lab · 5 clinical trial publications
20 registered trials · 11 with posted results
Furthest stage reached: Phase 2, results posted
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about Danuglipron
Evidence
Investigational
Category
Weight loss and metabolic
Common vial
Varies
Half-life
About 8 hours
How much, and do you cycle it?
The range, and whether you take breaks.40 up to 200 mg per dose, daily. No schedule. Development stopped in April 2025 Discontinued
Pfizer ended the program after a case of possible drug-induced liver injury, following the same fate as its sister compound the year before. Nothing about its dosing is worth planning around.
About 8 hoursTrial protocol
Measured in participants with normal kidney function. A twice-daily oral small molecule rather than a peptide.
Source: NCT04616027 posted results. Saxena AR, et al. Nat Med 2021;27:1079-1087
You can compare this against the whole library to see where it sits.
What does it cost?
Typical dose and cost, in plain numbers.Danuglipron is not injected in the forms covered here
It is taken by mouth (oral). Phase 2b used 40 to 200 mg twice daily. Pfizer stopped development in April 2025 after a participant showed signs of liver injury, so this is a historical dose, not an option.
How do you store it?
Before mixing, and after.Room temperature. Cool, dry, out of light.
Danuglipron is taken as a pill or capsule. Keep it in its original container at room temperature, away from heat, humidity, and direct sun. No fridge or mixing needed. Check the expiration date on the bottle.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Development has stopped, so it is not available and no prescriber is assessing anyone for it
Stop and get help
- Yellowing of the skin or eyes, dark urine, or severe unexplained tiredness, which can signal liver injury
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Nausea, vomiting, and diarrhea, which were severe enough in the earlier twice-daily version that more than half of participants stopped taking it
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Danuglipron approved?
And where the numbers on this page come from.No. Danuglipron is not approved anywhere and is currently in company-run clinical trials. There is no legal route to obtain it outside a trial.
- Approval statusInvestigational
- RouteBy mouth (oral)
- Checked22 July 2026
- DoseFrom a discontinued product or program. No current label supports this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesNone traced yet.
What has happened recently
Pfizer discontinued danuglipron in April 2025. One participant experienced a possible drug-induced liver injury, which resolved after stopping. An earlier twice-daily version had already been dropped in 2023 over how badly people tolerated it.
You can compare this against the whole library, or read how to check a seller.
What else is like Danuglipron?
Others in GLP-1 agonists, side by side.If you're weighing Danuglipron, it's worth reading Dulaglutide (Trulicity), Ecnoglutide, and Efinopegdutide in the same class.
An experimental weight-loss pill whose development was stopped over a liver-injury signal.
- Dose
- 40 up to 200 mg per dose
- How often
- Daily
A weekly GLP-1 shot for diabetes, with far less weight loss than the famous ones.
- Dose
- 0.75 up to 4.5 mg per week (start low, increase slowly)
- How often
- Weekly
A GLP-1 approved in China and licensed to Pfizer, and not approved in the US.
- Dose
- 1.2 to 2.4 mg
- How often
- Once weekly
An experimental weekly GLP-1/glucagon shot being studied for fatty liver disease, not for weight loss.
- Dose
- 2 up to 10 mg per week (trial doses, stepped up monthly)
- How often
- Weekly
Guides for this compound
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
- Semaglutide vs Tirzepatide vs Retatrutide
One receptor, two, or three. Mechanism, trial weight loss, side effects, and real cost.
Sources
No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence
Beyond these, 77 records are indexed. Browse the records