Danuglipron_
Also known as PF-06882961
An experimental weight-loss pill whose development was stopped over a liver-injury signal.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Danuglipron?
Plain language first. The technical label stays, but it never stands alone.Overview
Danuglipron is an oral GLP-1 receptor agonist and a small molecule, not a peptide, so it works as a pill. In plain terms: it gives GLP-1-style appetite control without injections. It is in testing.
What it's used for
An experimental appetite-lowering pill for weight loss, no needles. It is in testing.
How does Danuglipron work?
What it does in the body, and where.Danuglipron was an attempt at an oral GLP-1 pill using a small molecule rather than a peptide. Development stopped.
- 01It activated the GLP-1 receptor as a small moleculeThe same approach that orforglipron went on to succeed with.
- 02Development was halted in April 2025Pfizer stopped the programme after a participant showed signs of drug-induced liver injury, which resolved when the drug was withdrawn.
- 03It is here for reference, not as an optionThe dose figures on this page are historical. This is not something you can obtain or should be seeking.
Acts on one receptor.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Weight loss without injections. Development was discontinued in 2025, so nothing is approved or availableResearch only
How much, and do you cycle it?
The range, and whether you take breaks.40 up to 200 mg per dose, daily. No schedule. Development stopped in April 2025Discontinued
Pfizer ended the programme after a case of possible drug-induced liver injury, following the same fate as its sister compound the year before. Nothing about its dosing is worth planning around.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Danuglipron is not injected
It is taken by mouth (oral). Phase 2b used 40 to 200 mg twice daily. Pfizer stopped development in April 2025 after a participant showed signs of liver injury, so this is a historical dose, not an option.
How do you store it?
Before mixing, and after.Room temperature. Cool, dry, out of light.
Danuglipron is taken as a pill or capsule. Keep it in its original container at room temperature, away from heat, humidity, and direct sun. No fridge or mixing needed. Check the expiration date on the bottle.
What are the side effects and cautions?
Known cautions and warnings for this compound.22 July 2026Pfizer discontinued danuglipron in April 2025. One participant experienced a possible drug-induced liver injury, which resolved after stopping. An earlier twice-daily version had already been dropped in 2023 over how badly people tolerated it.
Who should avoid it
- Development has stopped, so it is not available and no prescriber is assessing anyone for it
Stop and get help
- Yellowing of the skin or eyes, dark urine, or severe unexplained tiredness, which can signal liver injury
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Nausea, vomiting, and diarrhea, which were severe enough in the earlier twice-daily version that more than half of participants stopped taking it
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Danuglipron approved?
And where the numbers on this page come from.No. Not FDA-approved.
Pfizer discontinued danuglipron in April 2025. One participant experienced a possible drug-induced liver injury, which resolved after stopping. An earlier twice-daily version had already been dropped in 2023 over how badly people tolerated it.
- DoseFrom published clinical trials. Not approved by a regulator for this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Reviewed22 July 2026
What else is like Danuglipron?
Others in Weight loss and metabolic, side by side.If you're weighing Danuglipron, it's worth reading Semaglutide, Tirzepatide, and Retatrutide in the same class.
An experimental weight-loss pill whose development was stopped over a liver-injury signal.
- Dose
- 40 up to 200 mg per dose
- How often
- Daily
The drug in Ozempic and Wegovy: a weekly shot that curbs hunger for steady weight loss.
- Dose
- 0.25 up to 2.4 mg per week (start low, increase slowly)
- How often
- Weekly
The drug in Mounjaro and Zepbound: a weekly shot for major weight loss and blood sugar.
- Dose
- 2.5 up to 15 mg per week (start low, increase slowly)
- How often
- Weekly
An experimental weekly shot with some of the biggest weight-loss numbers yet in trials.
- Dose
- 1 up to 12 mg per dose (start low, increase slowly)
- How often
- Weekly
10What these words mean
Show glossary +
What these words mean
- Titrate
- Starting at a low dose and increasing it slowly over time so your body adjusts and side effects stay mild.
- Subcutaneous
- An injection just under the skin, into the fat layer, usually with a short, thin insulin needle.
- Intramuscular (IM)
- An injection into a muscle, using a longer needle.
- Reconstitution
- Mixing a powdered peptide with liquid (bacteriostatic water) so it can be drawn into a syringe.
- Bacteriostatic water
- Sterile water with a tiny amount of preservative, used to mix powdered peptides.
- Concentration
- How strong the mixed peptide is, in milligrams per milliliter (mg/mL). More water makes it weaker; less water makes it stronger.
- Units (on the syringe)
- The marks on an insulin syringe. 100 units equals 1 mL. They measure how much liquid you draw, not the dose in milligrams.
- mcg and mg
- Units of dose. 1 milligram (mg) equals 1,000 micrograms (mcg).
- GLP-1
- A natural gut hormone that lowers appetite and blood sugar. Drugs that copy it, like semaglutide, are used for weight loss.
- Growth hormone secretagogue
- A compound that nudges your body to release more of its own growth hormone, rather than injecting the hormone itself.
- Half-life
- How long a compound stays active in your body. A longer half-life means you inject less often.
- Peptide vs small molecule
- A peptide is a short chain of amino acids. A few items here (like MK-677 or methylene blue) are small molecules, not true peptides, but people use them the same way.
- Research only
- No approved dose or use in people. Sold for research and not reviewed by the FDA for safety or quality.
- Investigational
- Still being tested in clinical trials and not yet approved or legally sold for general use.
- Banned in drug-tested sport
- Prohibited by the World Anti-Doping Agency (WADA); using it can disqualify a competing athlete.
Last reviewed 22 July 2026