Cagrilintide_Dosage, benefits & legal status
Also known as AM833, EZP-CG, EZP-CAG, C-10, GLP-1 C
A weekly fullness-hormone shot, often paired with semaglutide for bigger loss.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Cagrilintide?
Plain language first. The technical label stays, but it never stands alone.Overview
What it's used for
People use it to feel full and eat less by copying a natural fullness hormone. It is often paired with semaglutide for bigger weight loss.
How does Cagrilintide work?
What it does in the body, and where.Cagrilintide copies amylin rather than GLP-1. Amylin is a separate fullness hormone your pancreas releases alongside insulin, which is why it can be combined with a GLP-1 drug instead of competing with one.
- 01It acts on amylin receptorsA different 'stop eating' pathway from the GLP-1 drugs, running through the brainstem rather than the gut-hormone route.
- 02Fullness arrives sooner within a mealAmylin signaling shortens how long you keep eating once you have started, rather than blunting appetite between meals.
- 03Two pathways stackThis is the reasoning behind CagriSema, which pairs it with semaglutide so both fullness signals are switched on at once.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Weight loss, by copying the hormone that tells you you are fullInvestigational
- Weight loss combined with semaglutide, which is where most of the research has goneInvestigational
The published record
Papers and trials about Cagrilintide
Searched: Cagrilintide, AM833, EZP-CG, EZP-CAG.
Left out: C-10 (too short to disambiguate without context).
104 papers tagged human · 30 not reviews or lab · 15 clinical trial publications
44 registered trials · 1 with posted results
Furthest stage reached: Phase 3, completed, no results posted
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about Cagrilintide
Evidence
Investigational
Category
Weight loss and metabolic
Common vial
10 mg
Half-life
About 8 days
How much, and do you cycle it?
The range, and whether you take breaks.0.3 up to 4.5 mg per dose (start low, increase slowly), weekly. Not cycled in the trials Trial dose
Given continuously for the whole study period: 26 weeks on its own, 68 weeks as part of REDEFINE 1. The dose is stepped up at the start, which is a ramp rather than a cycle, and no trial in this class built in a planned break.
About 8 daysTrial protocol
Not yet traced to a primary source.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Cagrilintide starts at $32.49 across 107 vendors, typically $6.67 – $18.00 per mg.
173 listings, last read Oct 24, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Cagrilintide keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Solubility, computed: 16% charged residues, 43% hydrophobic. Acid may help.
A first-pass rule from peptide manufacturers' guidance. It does not account for disulfide bridges, salt form or how the powder was dried, and it predicts what should be easy rather than what will happen in your vial.
Who should avoid it
- No formal contraindications established, since it is still investigational
- Pregnancy
- Caution alongside other blood-sugar-lowering medicines
Stop and get help
- Severe stomach pain that spreads to your back
- Vomiting badly enough that you cannot keep fluids down
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Nausea, constipation, and diarrhea
- Mostly mild to moderate, and more frequent than placebo in trials
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Cagrilintide approved?
And where the numbers on this page come from.No. Cagrilintide is not approved anywhere and is currently in company-run clinical trials. There is no legal route to obtain it outside a trial.
- Approval statusInvestigational
- RouteUnder the skin (subcutaneous)
- Checked22 July 2026
- DoseFrom published clinical trials. Not approved by a regulator for this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesNone traced yet.
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
You can compare this against the whole library, or read how to check a seller.
What else is like Cagrilintide?
Others in Amylin analogs, side by side.If you're weighing Cagrilintide, it's worth reading Eloralintide, CagriSema, and Retatrutide + Cagrilintide blend in the same class.
A weekly fullness-hormone shot, often paired with semaglutide for bigger loss.
- Dose
- 0.3 up to 4.5 mg per dose (start low, increase slowly)
- How often
- Weekly
An experimental weekly fullness-hormone shot for weight loss.
- Dose
- 1 up to 9 mg per week (trial doses)
- How often
- Weekly
A weekly two-in-one shot combining cagrilintide and semaglutide for bigger loss.
- Dose
- 2.4 mg cagrilintide plus 2.4 mg semaglutide per week
- How often
- Weekly
An unapproved triple agonist paired with an amylin analog, tested by nobody.
- Dose
- Research only
- How often
- Weekly, by convention
Also sold in a blend: CagriSema, Retatrutide + Cagrilintide blend
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence
Beyond these, 152 records are indexed. Browse the records