Cagrilintide_
Also known as AM833
A weekly fullness-hormone shot, often paired with semaglutide for bigger loss.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Cagrilintide?
Plain language first. The technical label stays, but it never stands alone.Overview
Cagrilintide is a long-acting amylin analog, a copy of amylin, the hormone your pancreas releases with insulin to signal fullness. In plain terms: it works on a different 'stop eating' pathway than the GLP-1 drugs, which is why it is often paired with semaglutide for bigger results.
What it's used for
People use it to feel full and eat less by copying a natural fullness hormone. It is often paired with semaglutide for bigger weight loss.
How does Cagrilintide work?
What it does in the body, and where.Cagrilintide copies amylin rather than GLP-1. Amylin is a separate fullness hormone your pancreas releases alongside insulin, which is why it can be combined with a GLP-1 drug instead of competing with one.
- 01It acts on amylin receptorsA different 'stop eating' pathway from the GLP-1 drugs, running through the brainstem rather than the gut-hormone route.
- 02Fullness arrives sooner within a mealAmylin signalling shortens how long you keep eating once you have started, rather than blunting appetite between meals.
- 03Two pathways stackThis is the reasoning behind CagriSema, which pairs it with semaglutide so both fullness signals are switched on at once.
Acts on one receptor.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Weight loss, by copying the hormone that tells you you are fullInvestigational
- Weight loss combined with semaglutide, which is where most of the research has goneInvestigational
How much, and do you cycle it?
The range, and whether you take breaks.0.3 up to 4.5 mg per dose (start low, increase slowly), weekly. Not cycled in the trialsTrial dose
Given continuously for the whole study period: 26 weeks on its own, 68 weeks as part of REDEFINE 1. The dose is stepped up at the start, which is a ramp rather than a cycle, and no trial in this class built in a planned break.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
6 / 100 unitsHow do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Cagrilintide keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- No formal contraindications established, since it is still investigational
- Pregnancy
- Caution alongside other blood-sugar-lowering medicines
Stop and get help
- Severe stomach pain that spreads to your back
- Vomiting badly enough that you cannot keep fluids down
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Nausea, constipation, and diarrhea
- Mostly mild to moderate, and more frequent than placebo in trials
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Cagrilintide approved?
And where the numbers on this page come from.No. Not FDA-approved.
It is still being studied; a regulator has not cleared it for this use.
- DoseFrom published clinical trials. Not approved by a regulator for this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Reviewed22 July 2026
What else is like Cagrilintide?
Others in Weight loss and metabolic, side by side.If you're weighing Cagrilintide, it's worth reading Semaglutide, Tirzepatide, and Retatrutide in the same class.
A weekly fullness-hormone shot, often paired with semaglutide for bigger loss.
- Dose
- 0.3 up to 4.5 mg per dose (start low, increase slowly)
- How often
- Weekly
The drug in Ozempic and Wegovy: a weekly shot that curbs hunger for steady weight loss.
- Dose
- 0.25 up to 2.4 mg per week (start low, increase slowly)
- How often
- Weekly
The drug in Mounjaro and Zepbound: a weekly shot for major weight loss and blood sugar.
- Dose
- 2.5 up to 15 mg per week (start low, increase slowly)
- How often
- Weekly
An experimental weekly shot with some of the biggest weight-loss numbers yet in trials.
- Dose
- 1 up to 12 mg per dose (start low, increase slowly)
- How often
- Weekly
10What these words mean
Show glossary +
What these words mean
- Titrate
- Starting at a low dose and increasing it slowly over time so your body adjusts and side effects stay mild.
- Subcutaneous
- An injection just under the skin, into the fat layer, usually with a short, thin insulin needle.
- Intramuscular (IM)
- An injection into a muscle, using a longer needle.
- Reconstitution
- Mixing a powdered peptide with liquid (bacteriostatic water) so it can be drawn into a syringe.
- Bacteriostatic water
- Sterile water with a tiny amount of preservative, used to mix powdered peptides.
- Concentration
- How strong the mixed peptide is, in milligrams per milliliter (mg/mL). More water makes it weaker; less water makes it stronger.
- Units (on the syringe)
- The marks on an insulin syringe. 100 units equals 1 mL. They measure how much liquid you draw, not the dose in milligrams.
- mcg and mg
- Units of dose. 1 milligram (mg) equals 1,000 micrograms (mcg).
- GLP-1
- A natural gut hormone that lowers appetite and blood sugar. Drugs that copy it, like semaglutide, are used for weight loss.
- Growth hormone secretagogue
- A compound that nudges your body to release more of its own growth hormone, rather than injecting the hormone itself.
- Half-life
- How long a compound stays active in your body. A longer half-life means you inject less often.
- Peptide vs small molecule
- A peptide is a short chain of amino acids. A few items here (like MK-677 or methylene blue) are small molecules, not true peptides, but people use them the same way.
- Research only
- No approved dose or use in people. Sold for research and not reviewed by the FDA for safety or quality.
- Investigational
- Still being tested in clinical trials and not yet approved or legally sold for general use.
- Banned in drug-tested sport
- Prohibited by the World Anti-Doping Agency (WADA); using it can disqualify a competing athlete.
Last reviewed 22 July 2026