Tesamorelin_
Also known as Egrifta, TH9507
An approved shot proven to shrink stubborn belly fat.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Tesamorelin?
Plain language first. The technical label stays, but it never stands alone.Overview
Tesamorelin is a stabilized GHRH analog. In plain terms: it tells your body to make more growth hormone, and it is specifically proven to shrink deep belly fat. It is FDA-approved for HIV-related belly fat.
What it's used for
An approved shot proven to shrink stubborn belly fat by raising growth hormone. It is approved for HIV-related belly fat and used off-label by others for the same effect.
How does Tesamorelin work?
What it does in the body, and where.Tesamorelin is a GHRH copy that has been stabilised so it survives longer in the blood. It is the only peptide in this family with a specific approved use.
- 01It prompts your pituitary through the GHRH receptorThe same upstream approach as sermorelin, with a modification that resists the enzyme that would break it down.
- 02Deep belly fat shrinks specificallyTrials showed a reduction in visceral fat, the fat around your organs, rather than general weight loss.
- 03Approved for one narrow useFDA-approved for HIV-related belly fat accumulation. Other uses are off-label and not backed by the trials that produced the approval.
Where this compound is thought to act.
What else is it used for?
Each group carries its own evidence level.Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
Belly fat in HIV lipodystrophy
FDA-approved- Human trialIn two late-stage trials covering 806 patients, deep belly fat fell about 15% at 26 weeks and 18% at 52 weeks.
- Human trialFat just under the skin and overall BMI did not change, so the effect was specific to deep abdominal fat.
- RegulatoryApproved in 2010, with a newer weekly-mixing formulation approved in March 2025.
Liver fat
Investigational- Human trialOver 12 months, liver fat fell about 37% against a 5% increase on placebo.
- Human trial35% of people dropped below the fatty-liver threshold, against 4% on placebo.
- Human trialLiver scarring worsened in 10.5% of the treated group against 37.5% on placebo.
How much, and do you cycle it?
The range, and whether you take breaks.2 mg per day, daily. Not cycledFDA label
A daily drug taken continuously, with no on/off schedule on the label. In the phase 3 trial visceral fat fell about 15 percent over 26 weeks, and it returns toward baseline within months of stopping, so breaks undo the result rather than preserve it.
Source: Falutz et al., tesamorelin phase 3 (NEJM 2007) and EGRIFTA SV label
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
200 / 100 unitsHow do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Tesamorelin keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Active cancer
- Pregnancy
- Disruption of the pituitary gland from surgery, radiation, or tumour
Stop and get help
- New lumps or masses
- Severe swelling
- Signs of high blood sugar
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Injection-site redness, itching, or pain
- Joint aches
- Swelling in the hands or feet
- Muscle pain
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Tesamorelin approved?
And where the numbers on this page come from.Yes. FDA-approved.
A regulator reviewed the evidence and cleared it for specific uses.
- DoseFrom the drug label. The manufacturer tested this range and a regulator reviewed it.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
- Reviewed22 July 2026
What else is like Tesamorelin?
Others in Growth hormone, side by side.If you're weighing Tesamorelin, it's worth reading Ipamorelin, CJC-1295 with DAC, and CJC-1295 no DAC (Mod GRF 1-29) in the same class.
An approved shot proven to shrink stubborn belly fat.
- Dose
- 2 mg per day
- How often
- Daily
A gentle shot that nudges your body to release its own growth hormone.
- Dose
- 0.2 up to 0.3 mg per dose (start low, increase slowly)
- How often
- Daily, often at night
A once-or-twice-weekly shot that keeps your growth hormone raised for days.
- Dose
- 1 up to 2 mg per dose (start low, increase slowly)
- How often
- 1-2x per week
A short-acting growth-hormone pulse, usually paired with ipamorelin.
- Dose
- 0.1 mg per dose
- How often
- Daily to 2x daily
10What these words mean
Show glossary +
What these words mean
- Titrate
- Starting at a low dose and increasing it slowly over time so your body adjusts and side effects stay mild.
- Subcutaneous
- An injection just under the skin, into the fat layer, usually with a short, thin insulin needle.
- Intramuscular (IM)
- An injection into a muscle, using a longer needle.
- Reconstitution
- Mixing a powdered peptide with liquid (bacteriostatic water) so it can be drawn into a syringe.
- Bacteriostatic water
- Sterile water with a tiny amount of preservative, used to mix powdered peptides.
- Concentration
- How strong the mixed peptide is, in milligrams per milliliter (mg/mL). More water makes it weaker; less water makes it stronger.
- Units (on the syringe)
- The marks on an insulin syringe. 100 units equals 1 mL. They measure how much liquid you draw, not the dose in milligrams.
- mcg and mg
- Units of dose. 1 milligram (mg) equals 1,000 micrograms (mcg).
- GLP-1
- A natural gut hormone that lowers appetite and blood sugar. Drugs that copy it, like semaglutide, are used for weight loss.
- Growth hormone secretagogue
- A compound that nudges your body to release more of its own growth hormone, rather than injecting the hormone itself.
- Half-life
- How long a compound stays active in your body. A longer half-life means you inject less often.
- Peptide vs small molecule
- A peptide is a short chain of amino acids. A few items here (like MK-677 or methylene blue) are small molecules, not true peptides, but people use them the same way.
- Research only
- No approved dose or use in people. Sold for research and not reviewed by the FDA for safety or quality.
- Investigational
- Still being tested in clinical trials and not yet approved or legally sold for general use.
- Banned in drug-tested sport
- Prohibited by the World Anti-Doping Agency (WADA); using it can disqualify a competing athlete.
Sources
- FDA prescribing information, Egrifta(2010)FDA approval for HIV-related lipodystrophy; label last revised 2019.
- Tesamorelin Phase 3 trial, New England Journal of Medicine
- Tesamorelin liver fat trial, PubMed, 2019
Last reviewed 22 July 2026