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Decoding

Biotinoyl Tripeptide-1_Dosage, benefits & legal status

Also known as biotinyl-GHK, biotinyl tripeptide-1, Procapil component, biotinoyl GHK

By the Peptide Decoding Editorial Team

Published August 24, 2026

GHK with a biotin tail, sold for hair and lashes rather than skin.

Hair growthCosmetic peptideCosmetic

InSkin and cosmeticTaken without a needle

DoseSerum, 2 to 6 ppm typical in a finished product

FrequencyDaily

RouteOn the skin (topical)

StatusCosmetic ingredient

CycledNot cycled

Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.

See how this dose compares across the library →

What is Biotinoyl Tripeptide-1?

Plain language first. The technical label stays, but it never stands alone.

Overview

The same three amino acids as the copper peptide, carrying biotin instead of copper, and sold for hair rather than skin.

The technical version

Biotinylated GHK tripeptide. In vitro data reports increased laminin-5 and collagen IV expression in follicular keratinocytes. Human evidence derives from studies of the proprietary Procapil complex rather than the isolated peptide.

What it's used for

A hair and lash peptide, used for thinning hair, weak lashes and shedding.

How does Biotinoyl Tripeptide-1 work?

What it does in the body, and where.

The core of this molecule is GHK, the same tripeptide as the copper peptide, but the attachment is different and so is the use.

01
Same sequence, different passenger
GHK-Cu carries a copper ion. This one carries biotin. The sequence is identical, which is why the two are often confused, and the applications diverge completely.
02
It targets the follicle anchor
Laboratory work reports increased laminin-5 and collagen IV production in hair follicle cells, which are the proteins holding a follicle to the surrounding tissue.
03
It is nearly always sold in a blend
Most products containing it also contain apigenin and oleanolic acid under the trade name Procapil, and the published figures belong to that combination.

Where it acts

ScalpLashes

Where this compound is thought to act.

What else is it used for?

Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.

Reducing hair shedding and supporting follicle anchoringSupplement or cosmetic
Increasing eyelash and eyebrow lengthEarly research
Increasing hair density over months of useEarly research

The published record

Research index

Papers and trials about Biotinoyl Tripeptide-1

2 papers tagged human · 0 not reviews or lab · 0 clinical trial publications

2 registered trials · none with posted results

Furthest stage reached: No clinical trial on record

Compare this against the whole library →

Browse the records

In animals0

In the lab0

Reviews0

Senior author shareSpread across many groups

Evidence summary

Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.

Compound field notes

At a glance

Four things to know about Biotinoyl Tripeptide-1

Evidence

Cosmetic

How much, and do you cycle it?

The range, and whether you take breaks.

Serum, 2 to 6 ppm typical in a finished product, daily. Not cycled Community practice

Used daily as part of a routine. The effect depends on continued use and fades when you stop, so there is nothing to cycle off.

Compare this against the whole library →

How long does it stay in the body?

The half-life, and where the figure comes from.

Not measured, and not the right questionNo figure

This is a topical cosmetic ingredient. A blood half-life measures how fast something leaves the bloodstream, and these are not intended to reach it in meaningful amounts. What matters is how much crosses the skin and how long it stays in the tissue, which is a different measurement and rarely published.

You can compare this against the whole library to see where it sits.

What does it cost?

Typical dose and cost, in plain numbers.

Biotinoyl Tripeptide-1 is not injected

It is taken on the skin (topical). Applied as a topical product at the concentration the manufacturer sets. There is no injected dose.

Cost per month

—

Cost per dose

—

Typical dose

0.6 mcg–25 mcg / formulationCommunity practice

ExperChem →

How do you store it?

Before mixing, and after.

Room temperature, out of light. Cap it tight after each use.

Biotinoyl Tripeptide-1 ships as a cream, gel, or serum. Keep it at room temperature away from sun and heat unless the label says otherwise. Refrigerating an emulsion can split the texture. Watch for color, smell, or separation changes and stop using it if any appear.

What are the side effects and cautions?

Known cautions and warnings for this compound.

Who should avoid it

Check these before anything else.

Broken or actively inflamed scalp skin
A known allergy to any component of the finished product

Stop and get help

These are emergencies. Seek care.

Eye irritation that does not settle after stopping a lash product
A spreading rash where applied

Common effects

Expected, and usually mild.

Very well tolerated in cosmetic use.
Occasional irritation on the eyelid margin from lash products, usually from the formula rather than the peptide.

Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.

Is Biotinoyl Tripeptide-1 approved?

And where the numbers on this page come from.

Not as a medicine. Biotinoyl Tripeptide-1 is sold without a prescription as a cosmetic ingredient, which is a different thing from being approved as a drug.

Approval status
CosmeticSold without a prescription as an ingredient in cosmetics, such as skincare and hair products. The FDA does not approve cosmetics before they are sold, and being easy to buy says nothing about whether it works.
Route
On the skin (topical)
Checked
24 August 2026
Dose
From the concentration range manufacturers formulate at. This is a product strength, not a dose set by a regulator or a trial.
Vial size
From what vendors typically list; not a recommendation.
Sources
None traced yet.

What has happened recently

We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.

You can compare this against the whole library, or read how to check a seller.

What else is like Biotinoyl Tripeptide-1?

Others in Skin and cosmetic, side by side.

If you're weighing Biotinoyl Tripeptide-1, it's worth reading Hexapeptide-11, Melanotan III, and Myristoyl Pentapeptide-17 in the same class.

YOU ARE HERE

Biotinoyl Tripeptide-1

GHK with a biotin tail, sold for hair and lashes rather than skin.

Supplement or cosmetic

Dose: Serum, 2 to 6 ppm typical in a finished product
How often: Daily

HEXA-11

Hexapeptide-11

A yeast-derived cosmetic peptide for elasticity, with a thin evidence trail.

Supplement or cosmetic

Dose: Serum, per product
How often: Daily

MT-3

Melanotan III

A name sold on the research market with no molecule publicly attached to it.

Research only

Dose: Research only
How often: Not established

MYRP-17

Myristoyl Pentapeptide-17

The lash-serum peptide, used where people want to avoid prostaglandins.

Supplement or cosmetic

Dose: Serum, per product
How often: Daily

See other skin and cosmetic peptides Compare oral, nasal, and topical peptides

Guides for this compound

mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.

Sources

No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence

Beyond these, 4 records are indexed. Browse the records