Lixisenatide (Adlyxin)_Dosage, benefits & legal status
Also known as Adlyxin, Lyxumia, AVE0010
An approved GLP-1 that lost the race and left the US market.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Lixisenatide (Adlyxin)?
Plain language first. The technical label stays, but it never stands alone.Overview
A real approved GLP-1 that got beaten by the weekly ones and pulled from the market. It still exists inside a combination pen with insulin.
Lixisenatide, a short-acting GLP-1 receptor agonist, FDA-approved 27 July 2016 as Adlyxin for glycaemic control in adults with type 2 diabetes. Sanofi discontinued the standalone product globally for commercial reasons. The molecule remains available in the US inside Soliqua, a fixed-ratio combination with insulin glargine. The label carries warnings for anaphylaxis and acute pancreatitis and states it is not recommended in end stage renal disease.
What it's used for
A daily injected GLP-1 for type 2 diabetes. No longer marketed in the US on its own.
How does Lixisenatide (Adlyxin) work?
What it does in the body, and where.Lixisenatide is a useful reference point for how quickly this drug class moved.
- 01It is a short-acting, meal-time GLP-1Given once daily, it acts mainly on the glucose rise after eating. Semaglutide and dulaglutide are weekly and act more on fasting glucose, which is part of why they displaced it.
- 02Approved in 2016, and largely gone by 2023The FDA approved it in July 2016. Sanofi discontinued it globally for commercial reasons, not safety ones, and it is no longer marketed as a standalone product in the US.
- 03It survives inside a combination productSoliqua pairs lixisenatide with insulin glargine in one pen, and that product remains available.
Acts on one receptor.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Type 2 diabetes, alongside diet and exerciseFDA-approved
- As part of Soliqua, a fixed combination with insulin glargineFDA-approved
- Weight loss on its own, which is not its approved indicationnone
The published record
Papers and trials about Lixisenatide (Adlyxin)
376 papers tagged human · 184 not reviews or lab · 90 clinical trial publications
75 registered trials · 27 with posted results
Furthest stage reached: Approved in the US, no longer sold
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count. 461 papers and 75 trials indexed in detail.
At a glance
Four things to know about Lixisenatide (Adlyxin)
Evidence
FDA-approved
Category
Weight loss and metabolic
Common vial
Varies
Half-life
About 3 hours
How much, and do you cycle it?
The range, and whether you take breaks.Set by the label, once daily. Set by the prescription FDA label
This is a prescription drug. Duration and schedule are set by the label and the prescriber, not by a cycling convention.
About 3 hoursFDA label
Terminal half-life after repeated dosing in people with type 2 diabetes. This is the short-acting end of the GLP-1 family, which is why it is given once daily rather than weekly.
Source: Adlyxin label section 12.3
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
This amount is too small to measure with any of these mixes. Check whether you meant mg or mcg.
Measuring the water1 mL = one full 100-unit syringe.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Lixisenatide (Adlyxin) keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Solubility, computed: 39% charged residues, 32% hydrophobic. Water usually sufficient.
A first-pass rule from peptide manufacturers' guidance. It does not account for disulfide bridges, salt form or how the powder was dried, and it predicts what should be easy rather than what will happen in your vial.
Who should avoid it
- Severe hypersensitivity to lixisenatide or any component of the product
- Pregnancy or breastfeeding, without medical advice
- End stage renal disease, where the label says it is not recommended
- A history of pancreatitis
Stop and get help
- Severe or persistent abdominal pain, which can signal pancreatitis
- Signs of an allergic reaction, including facial or throat swelling or trouble breathing
- Symptoms of very low blood sugar
Common effects
- Nausea
- Vomiting
- Headache
- Low blood sugar when combined with other diabetes drugs
- Injection site reactions
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Lixisenatide (Adlyxin) approved?
And where the numbers on this page come from.Approved, but no longer sold in the United States. Lixisenatide (Adlyxin) was approved by the FDA, and the US product has since been discontinued.
- Approval statusFDA-approved
- RouteUnder the skin (subcutaneous)
- Checked24 August 2026
- DoseFrom the drug label. The manufacturer tested this range and a regulator reviewed it.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesNone traced yet.
What has happened recently
FDA-approved 27 July 2016 as Adlyxin for type 2 diabetes. The standalone product was discontinued globally by Sanofi for commercial reasons, not safety. Lixisenatide remains available in the US within Soliqua, a fixed-ratio combination with insulin glargine.
You can compare this against the whole library, or read how to check a seller.
What else is like Lixisenatide (Adlyxin)?
Others in GLP-1 agonists, side by side.If you're weighing Lixisenatide (Adlyxin), it's worth reading MariTide (maridebart cafraglutide), MBX 4291, and Pemvidutide in the same class.
An approved GLP-1 that lost the race and left the US market.
- Dose
- Set by the label
- How often
- Once daily
An experimental once-a-month obesity shot.
- Dose
- 140 up to 420 mg per month (trial doses)
- How often
- Monthly
An experimental once-monthly GLP-1/GIP prodrug in its first human trial.
- Dose
- 30 mg weekly for 4 weeks, then 120 to 180 mg monthly (trial regimens)
- How often
- Weekly, then monthly (trial regimens)
An experimental weekly shot for weight loss and fatty liver.
- Dose
- 1.2 up to 2.4 mg per week (trial doses)
- How often
- Weekly
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- Semaglutide vs Tirzepatide vs Retatrutide
One receptor, two, or three. Mechanism, trial weight loss, side effects, and real cost.
Sources
No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence
Beyond these, 536 records are indexed. Browse the records