Spexin_Dosage, benefits & legal status
Also known as NPQ, neuropeptide Q, SPX
An appetite peptide found by computer search, still almost entirely in animals.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Spexin?
Plain language first. The technical label stays, but it never stands alone.Overview
An appetite peptide found by database search. The weight loss numbers attached to it were measured in animals.
Spexin (neuropeptide Q), a short amidated neuropeptide identified through in silico genome mining, reported to signal at galanin receptors GALR2 and GALR3. Preclinical data covers food intake and body weight in rodent and fish models. Human literature is observational, reporting reduced circulating concentrations in obesity. No published human administration trial.
What it's used for
Sold for appetite control and weight loss on the basis of animal studies.
How does Spexin work?
What it does in the body, and where.Spexin was found the way several compounds in this category were, by looking for peptide-shaped genes rather than by chasing an effect.
- 01Identified in silicoFound by computational search of genome databases for sequences with the hallmarks of a secreted peptide, then synthesised and tested afterward.
- 02It acts at galanin receptorsReported to signal through galanin receptors 2 and 3, which are involved in appetite and mood, rather than through the GLP-1 system that the approved weight drugs use.
- 03The human data is levels, not outcomesStudies report lower circulating spexin in people with obesity. As with adropin, that is an association and does not establish that supplying it changes weight.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Appetite suppression and body weightEarly research
- Obesity, where blood levels are reported lowerEarly research
- Glucose and lipid metabolismEarly research
The published record
Papers and trials about Spexin
117 papers tagged human · 87 not reviews or lab · 7 clinical trial publications
1 registered trials · none with posted results
Furthest stage reached: Published trials only, 7 clinical trial publications, no phased trial registered
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about Spexin
Evidence
Category
Weight loss and metabolic
Common vial
Varies
Half-life
Nothing published
How much, and do you cycle it?
The range, and whether you take breaks.Research only, not established. Not established No range
No schedule has been studied for this compound in people.
Nothing publishedNo figure
No half-life has been published for administered spexin in people.
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Spexin keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Solubility, computed: 21% charged residues, 50% hydrophobic. Acid may help.
A first-pass rule from peptide manufacturers' guidance. It does not account for disulfide bridges, salt form or how the powder was dried, and it predicts what should be easy rather than what will happen in your vial.
Who should avoid it
- Pregnancy or breastfeeding
- Any eating disorder, or a history of one
- Diabetes or any diagnosed metabolic condition, without medical advice
- Anyone who wants established safety data, because none exists for this compound in humans
Stop and get help
- Signs of an allergic reaction, including spreading hives, facial or throat swelling, or trouble breathing
- Redness, heat, or pus at the injection site, which can signal infection
- Anything unusual, since there is no known safety profile to compare it against
Common effects
- Unknown. No study has recorded what this commonly causes in people
- Redness, soreness, or a small bump at the injection site
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Spexin approved?
And where the numbers on this page come from.No. Spexin is not approved for any use, anywhere. It is sold labeled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin (subcutaneous)
- Checked24 August 2026
- DoseNo dose has been established in people.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesNone traced yet.
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
You can compare this against the whole library, or read how to check a seller.
What else is like Spexin?
Others in Fat loss without GLP-1, side by side.If you're weighing Spexin, it's worth reading 5-Amino-1MQ, AOD-9604, and Melanotan II in the same class.
An appetite peptide found by computer search, still almost entirely in animals.
- Dose
- Research only
- How often
- Not established
A capsule studied for speeding up metabolism and burning fat.
- Dose
- 0.15 up to 5 mg per day injected (the capsule dose is far higher, see below)
- How often
- Daily, cycled
A growth-hormone fragment marketed for fat loss, with weak proof it works.
- Dose
- 0.3 mg per day
- How often
- Daily
A shot for a fast, deep tan, plus libido and appetite effects.
- Dose
- 0.25 up to 1 mg per dose (start low, increase slowly)
- How often
- Daily loading, then maintenance
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence
Beyond these, 277 records are indexed. Browse the records