Ecnoglutide_Dosage, benefits & legal status
Also known as XW003, Xianweiying
A GLP-1 approved in China and licensed to Pfizer, and not approved in the US.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Ecnoglutide?
Plain language first. The technical label stays, but it never stands alone.Overview
A weekly weight loss injection approved in China, licensed to Pfizer there, and not approved in the US. Its Phase 3 trial reported 15.1% weight loss over 48 weeks.
A cAMP-biased GLP-1 receptor agonist with an Ala8Val substitution and a C18 diacid fatty acid conjugated at Lys30. cAMP EC50 reported at 0.018 nM with receptor internalisation EC50 above 10 uM. Approved by the NMPA for weight management and type 2 diabetes; not FDA-approved.
What it's used for
Approved in China for weight management and for type 2 diabetes. Not approved in the United States, Europe or the UK.
How does Ecnoglutide work?
What it does in the body, and where.Two GLP-1 drugs can hit the same receptor and produce different downstream traffic.
- 01It favours cAMP over receptor internalisationLaboratory work reports potent cAMP induction with very little receptor internalisation. The proposal is that a receptor which stays on the cell surface keeps responding.
- 02The design is also about manufacturingIt is built from natural amino acids only, with a single substitution and a fatty acid chain, which the developers describe as simplifying production compared with other analogues.
- 03The half-life supports weekly dosingSteady-state half-life is reported at 124 to 138 hours, comparable to the other weekly GLP-1 drugs.
What else is it used for?
Each group carries its own evidence level.Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
Weight loss
Clinical use- In the SLIMMER Phase 3 trial, 664 Chinese adults with overweight or obesity received once-weekly ecnoglutide at 1.2, 1.8 or 2.4 mg or placebo for 48 weeks. At the highest dose, participants lost up to 13.8 kg against roughly 200 g on placebo, with 92.8% losing at least 5% of body weight against 14% on placebo. Reported weight loss was 15.1% at 48 weeks with no plateau evident.
- Participants largely maintained the loss after stopping, regaining around 1% of body weight over seven weeks, which is a notably different pattern from the semaglutide withdrawal data.
Blood sugar
Clinical use- In the EECOH-1 Phase 3 trial, 211 participants with type 2 diabetes across 32 centres received 0.6 or 1.2 mg weekly or placebo for 24 weeks, with HbA1c at week 24 as the primary endpoint.
Sold by research vendors as a next-generation GLP-1 without noting that it is approved in China and nowhere else. Approval by China's regulator does not predict FDA approval and does not place a drug on the US market. A vial bought from a website is also not the approved product.
How much, and do you cycle it?
The range, and whether you take breaks.1.2 to 2.4 mg, once weekly. Continuous weekly dosingTrial dose
Trials dosed weekly and continuously across 24 to 48 weeks. As with the rest of the class, the effect depends on continued treatment.
How long does it stay in the body?
The half-life, and where the figure comes from.124 to 138 hours at steady statepeer-reviewed
Supports once-weekly dosing. Measured in healthy participants.
Source: Phase 1 pharmacokinetic study, NCT04389775
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
0 / 100 unitsHow do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Ecnoglutide keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- A personal or family history of medullary thyroid carcinoma or MEN2, per the class
- Pregnancy or breastfeeding
- A history of pancreatitis
Stop and get help
- Severe or persistent abdominal pain, which can indicate pancreatitis
- A lump or swelling in the neck, hoarseness or trouble swallowing
- Any allergic reaction
Common effects
- Nausea, reduced appetite and headache were the reported adverse events in early trials.
- Described as generally safe and well tolerated across Phase 1 to Phase 3.
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Ecnoglutide approved?
And where the numbers on this page come from.No. Ecnoglutide is not approved anywhere and is currently in company-run clinical trials. There is no legal route to obtain it outside a trial.
- Approval statusInvestigational
- RouteUnder the skin (subcutaneous)
- CheckedAugust 2026
- Approved outside the USThis does not change the United States position above.
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
You can compare this against the whole library, or read how to check a seller.
- DoseFrom published clinical trials. Not approved by a regulator for this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Reviewed24 August 2026
What else is like Ecnoglutide?
Others in GLP-1 agonists, side by side.If you're weighing Ecnoglutide, it's worth reading Lixisenatide (Adlyxin), Albiglutide (Tanzeum), and Beinaglutide in the same class.
A GLP-1 approved in China and licensed to Pfizer, and not approved in the US.
- Dose
- 1.2 to 2.4 mg
- How often
- Once weekly
An approved GLP-1 that lost the race and left the US market.
- Dose
- Set by the label
- How often
- Once daily
A weekly GLP-1 withdrawn from the world market because nobody bought it.
- Dose
- Was set by the label
- How often
- Once weekly
China's own GLP-1, and the only one with a fully human sequence.
- Dose
- Set by the Chinese label
- How often
- Three times daily, before meals
10What these words mean
Show glossary +
What these words mean
- 503A and 503B
- The two kinds of compounding pharmacy in US law. A 503A pharmacy prepares medicine for one named patient. A 503B outsourcing facility makes larger batches under stricter manufacturing rules.
- Agonist
- Something that switches a receptor on. The opposite is an antagonist. It blocks the receptor instead.
- Amino acid
- The building blocks that link together in a chain to make a peptide or a protein. The order they sit in is what makes one peptide different from another.
- Amylin
- A hormone released alongside insulin that slows the stomach emptying and reduces appetite. Several weight loss compounds copy it.
- Analog
- A compound built to copy a natural one with small deliberate changes, usually so it lasts longer or holds onto its target more tightly.
- Animal study
- Research done in rats, mice or other animals. Most findings do not repeat in people, so an animal result is a reason to keep looking. It is not a reason to act.
- Antibody
- A large immune protein, far bigger than a peptide, engineered to lock onto one specific target. These are made by drug companies and are not sold as research powders.
- Bacteriostatic water
- Sterile water with a tiny amount of preservative, used to mix powdered peptides.
- Banned in drug-tested sport
- Prohibited by the World Anti-Doping Agency (WADA); using it can disqualify a competing athlete.
- Bioavailability
- How much of a dose actually reaches your bloodstream. Most peptides survive stomach acid badly, so most of them are injected instead of swallowed.
- Bioregulator
- Very short peptides from a Russian research tradition, usually two to four amino acids long, sold for supporting a specific organ. Human evidence is thin and most of it is published in Russian.
- Blend
- One vial holding more than one compound, mixed together by the seller. Working out a dose means working out each ingredient separately, because they are rarely present in equal amounts.
- Boxed warning
- The most serious warning the FDA puts on a drug label, printed inside a black border. It flags a risk considered severe enough to sit above everything else on the label.
- Bulks list
- The FDA's list of ingredients that compounding pharmacies are allowed to use. A substance can sit under review on it for years without anything being decided either way.
- Certificate of analysis (COA)
- A lab report on a batch of product. It only means something if it names the batch you actually received, comes from an independent lab, and can be checked with that lab.
- Clinical trial
- A study that gives a treatment to people under a written plan and measures what happens. It is the only kind of evidence that can show something works in humans.
- Compounding
- A licensed pharmacy preparing a medicine to order. Being allowed to compound something is not the same as the FDA approving it, and the two get mixed up constantly.
- Concentration
- How strong the mixed peptide is, in milligrams per milliliter (mg/mL). More water makes it weaker; less water makes it stronger.
- Cycle
- A stretch of time using a compound followed by a break. Most cycling patterns come from community practice. Very few have been tested.
- DAC
- Short for Drug Affinity Complex. An attachment added to a peptide so it grabs onto a blood protein and stays in the body for days instead of minutes.
- Dead space
- The small amount of liquid left sitting inside the needle and hub after you inject. On very small doses it can be a real share of what you meant to take.
- Dilute
- Adding more liquid to make a mix weaker. The amount of peptide in the vial does not change. It is just spread through more water, so each draw is bigger.
- Endpoint
- The result a trial said in advance that it would measure. A study can be reported as positive and still have missed the endpoint it set out to hit.
- FDA approved
- Reviewed by the FDA and cleared for a specific use, in a specific form, at a specific dose. Approval for one use is not approval for another, and approval in another country is not approval here.
- Fragment
- A short piece cut out of a larger natural protein. A fragment can behave very differently from the whole protein it came from, so evidence about one does not transfer to the other.
- Ghrelin
- The hunger hormone. Some growth hormone compounds work by copying it, so they can make you noticeably hungrier.
- GHRH
- A natural signal telling the pituitary gland to release growth hormone. Several compounds copy it.
- GHRP
- A second, separate signal that also triggers growth hormone release, through a different door than GHRH. This is why the two types are often used together.
- GLP-1
- A natural gut hormone that lowers appetite and blood sugar. Drugs that copy it, like semaglutide, are used for weight loss.
- Growth hormone secretagogue
- A compound that nudges your body to release more of its own growth hormone, rather than injecting the hormone itself.
- Half-life
- How long a compound stays active in your body. A longer half-life means you inject less often.
- HPLC
- A lab method that separates out everything in a sample so the amounts can be measured. It shows how much of the main ingredient is there. It does not confirm that the main ingredient is the right molecule.
- In vitro
- Done in a dish or a test tube, on cells outside a living body. It is the earliest kind of evidence there is.
- Injection site
- The spot on the body where you inject. Moving it around gives the skin and fat underneath time to recover between doses.
- Intramuscular (IM)
- An injection into a muscle, using a longer needle.
- Intravenous (IV)
- An injection into a vein. It needs training and equipment and is not something to do at home.
- Investigational
- Still being tested in clinical trials and not yet approved or legally sold for general use.
- Lyophilized
- Freeze-dried into a powder so it keeps longer. That is the white cake or dust in the bottom of an unmixed vial.
- Mass spectrometry
- A lab method that weighs molecules to confirm what they are. HPLC answers how much is in the sample. This answers what it is.
- mcg and mg
- Units of dose. 1 milligram (mg) equals 1,000 micrograms (mcg).
- Myostatin
- A natural brake on muscle growth. Several compounds are built to block it, though human results have been far smaller than the animal work suggested.
- Off-label
- A doctor prescribing an approved drug for something other than its approved use. This is legal and common, and it is different from a compound having no approval at all.
- Orphan drug designation
- A status given to treatments for rare conditions to make them worth developing. It is an incentive, not an approval, and a compound can hold it while being approved for nothing.
- PCAC
- The FDA advisory committee that reviews compounding ingredients. It recommends. It does not approve, and the FDA does not have to follow what it says.
- Peer review
- Other scientists checking a paper before a journal publishes it. It filters out some bad work. It does not make a finding true.
- Peptide vs small molecule
- A peptide is a short chain of amino acids. A few items here (like MK-677 or methylene blue) are small molecules, not true peptides, but people use them the same way.
- Placebo
- A dummy treatment given for comparison. Without one it is very hard to tell a real effect apart from expectation and time passing.
- Purity
- The share of a sample that is the intended compound, usually given as a percentage. A high purity number on the wrong molecule is still the wrong molecule.
- Randomized
- Deciding by chance who gets which treatment, so the two groups are comparable. Studies that skip this are much easier to read the wrong way.
- Receptor
- A docking point on a cell that a compound attaches to. If a cell has no matching receptor, the compound does nothing to it.
- Reconstitution
- Mixing a powdered peptide with liquid (bacteriostatic water) so it can be drawn into a syringe.
- Research only
- No approved dose or use in people. Sold for research and not reviewed by the FDA for safety or quality.
- Stack
- Using more than one compound at the same time. Almost no combinations have been tested together in people, so a stack is usually built on guesswork.
- Sterile water
- Water with nothing added to stop bacteria growing. It works for a single dose, but a vial mixed with it should not be kept and used again.
- Subcutaneous
- An injection just under the skin, into the fat layer, usually with a short, thin insulin needle.
- Titrate
- Starting at a low dose and increasing it slowly over time so your body adjusts and side effects stay mild.
- Trial phases
- The stages of human testing. Phase 1 checks safety in a small group, phase 2 looks for an effect, and phase 3 tests it against a comparison in a large group.
- Units (on the syringe)
- The marks on an insulin syringe. 100 units equals 1 mL. They measure how much liquid you draw, not the dose in milligrams.
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Last reviewed 24 August 2026
Peptide Decoding is published by Decoded Sciences LLC. We take no payment from vendors for coverage, inclusion or ranking, and our affiliate relationships are disclosed in full.