Palmitoyl Tripeptide-5_Dosage, benefits & legal status
Also known as Syn-Coll, SynColl, palmitoyl tripeptide 5, tripeptide-5
A collagen peptide that works by activating a growth factor rather than mimicking damage.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Palmitoyl Tripeptide-5?
Plain language first. The technical label stays, but it never stands alone.Overview
A collagen peptide sold as Syn-Coll. It reaches the same result as Matrixyl by a different route, and most of its evidence comes from the company selling it.
Pal-KVK bistrifluoroacetate. Reported mechanism is TGF-beta pathway activation driving type I collagen synthesis, distinguishing it from the matrikine-mimetic mechanism of Pal-KTTKS. Supporting efficacy data is predominantly manufacturer-generated.
What it's used for
A skin peptide used for firmness, fine lines and skin thickness.
How does Palmitoyl Tripeptide-5 work?
What it does in the body, and where.Two peptides can both raise collagen and get there by different routes, and this is the other route.
- 01Matrixyl mimics damage, this activates a signalMatrixyl is a collagen fragment that skin reads as evidence of damage. This peptide is described instead as activating TGF-beta, a growth factor that drives collagen synthesis directly.
- 02The palmitoyl tail does the deliverySame principle as Matrixyl. A fatty acid attached to a water-loving peptide is what gets it through the lipid barrier.
- 03The published evidence is manufacturer dataThe trade name is Syn-Coll and the supporting studies come from the company that sells it. That is normal in cosmetics and it is worth knowing when reading the figures.
Where this compound is thought to act.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Improving skin firmness and reducing fine lines, applied topicallySupplement or cosmetic
- Increasing collagen production in skin cellsEarly research
- Reducing the appearance of stretch marks and scarsEarly research
The published record
Papers and trials about Palmitoyl Tripeptide-5
4 papers tagged human · 2 not reviews or lab · 1 clinical trial publications
2 registered trials · none with posted results
Furthest stage reached: Published trials only, 1 clinical trial publication, no phased trial registered
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about Palmitoyl Tripeptide-5
Evidence
Cosmetic
Category
Skin and cosmetic
Common vial
Varies
Half-life
Not measured, and not the right question
How much, and do you cycle it?
The range, and whether you take breaks.Serum or cream, typically 200 mg of active per formulation batch, daily. Not cycled Community practice
Used daily as part of a routine. The effect depends on continued use and fades when you stop, so there is nothing to cycle off.
Not measured, and not the right questionNo figure
This is a topical cosmetic ingredient. A blood half-life measures how fast something leaves the bloodstream, and these are not intended to reach it in meaningful amounts. What matters is how much crosses the skin and how long it stays in the tissue, which is a different measurement and rarely published.
You can compare this against the whole library to see where it sits.
What does it cost?
Typical dose and cost, in plain numbers.Palmitoyl Tripeptide-5 is not injected
It is taken on the skin (topical). Applied as a topical product at the concentration the manufacturer sets. There is no injected dose.
Palmitoyl Tripeptide-5 starts at $176.00 across 3 vendors, typically $1.09 per mg.
3 listings, last read Oct 10, 2026. Shipping and card fees are not included.
How do you store it?
Before mixing, and after.Room temperature, out of light. Cap it tight after each use.
Palmitoyl Tripeptide-5 ships as a cream, gel, or serum. Keep it at room temperature away from sun and heat unless the label says otherwise. Refrigerating an emulsion can split the texture. Watch for color, smell, or separation changes and stop using it if any appear.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Broken or actively inflamed skin
- A known allergy to any component of the finished product
Stop and get help
- A spreading rash or significant swelling where applied
Common effects
- Very well tolerated on the skin.
- Occasional mild irritation, usually formulation-related.
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Palmitoyl Tripeptide-5 approved?
And where the numbers on this page come from.Not as a medicine. Palmitoyl Tripeptide-5 is sold without a prescription as a cosmetic ingredient, which is a different thing from being approved as a drug.
- Approval statusCosmeticSold without a prescription as an ingredient in cosmetics, such as skincare and hair products. The FDA does not approve cosmetics before they are sold, and being easy to buy says nothing about whether it works.
- RouteOn the skin (topical)
- Checked24 August 2026
- DoseFrom the concentration range manufacturers formulate at. This is a product strength, not a dose set by a regulator or a trial.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesNone traced yet.
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
You can compare this against the whole library, or read how to check a seller.
What else is like Palmitoyl Tripeptide-5?
Others in Skin and cosmetic, side by side.If you're weighing Palmitoyl Tripeptide-5, it's worth reading Tripeptide-29, Vialox (Pentapeptide-3), and Acetyl Tetrapeptide-11 in the same class.
A collagen peptide that works by activating a growth factor rather than mimicking damage.
- Dose
- Serum or cream, typically 200 mg of active per formulation batch
- How often
- Daily
A three-amino-acid collagen fragment sold as a signal for firmer skin.
- Dose
- Topical serum, per product
- How often
- Daily
A topical peptide that blocks the muscle's receiving end, sold as needle-free Botox.
- Dose
- Serum, per product
- How often
- Daily
A topical cosmetic peptide sold as Syniorage, claimed to firm mature skin by raising syndecan-1 and collagen XVII.
- Dose
- Serum or cream, per product
- How often
- Daily
Guides for this compound
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence
Beyond these, 8 records are indexed. Browse the records