PT-141 (Bremelanotide)_
Also known as bremelanotide, Vyleesi, PT141
An approved shot that boosts sexual desire through the brain.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is PT-141 (Bremelanotide)?
Plain language first. The technical label stays, but it never stands alone.Overview
PT-141 (bremelanotide) is a melanocortin receptor agonist, a cyclic peptide that acts on the MC4R receptor in the brain. In plain terms: it raises sexual desire through brain signaling rather than blood flow, which is different from how erection drugs work. It is FDA-approved for low libido in women.
What it's used for
An approved shot that boosts sexual desire and arousal by acting on the brain rather than blood flow. It is used for low libido in both women and men.
How does PT-141 (Bremelanotide) work?
What it does in the body, and where.PT-141 works on the brain rather than on blood flow, which makes it fundamentally different from the erectile-dysfunction drugs it gets compared to.
- 01It activates MC4R in the brainA melanocortin receptor involved in sexual desire, appetite, and arousal signalling.
- 02Desire rises, rather than blood flowDrugs like sildenafil act on blood vessels. This acts upstream of that, on the wanting rather than the mechanics.
- 03Approved for one specific groupFDA-approved as Vyleesi for low sexual desire in premenopausal women. Use in men is off-label and less studied.
Where this compound is thought to act.
What else is it used for?
Each group carries its own evidence level.Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
Sexual desire in women
FDA-approved- RegulatoryApproved by the FDA in June 2019 for low sexual desire that causes distress in premenopausal women.
- Human trialTwo late-stage trials in more than 1,200 women showed improved desire and reduced distress against placebo, though the effect was modest.
- Human trialNausea affected 40% of users, particularly with the first injection. It required anti-nausea treatment in 13% and caused 8% to stop.
Sexual function in men
Investigational- Human trialIn men who did not respond to standard erection drugs, about 34% responded against 9% on placebo.
- No dataCompounded versions are not the approved product and have not been reviewed by the FDA.
The approved use is in women, and the male findings come from smaller off-label studies we could not link to a primary source.
How much, and do you cycle it?
The range, and whether you take breaks.1.75 mg per dose, as needed, before activity. Not cycled, but the label caps it: one dose in 24 hours, and no more than 8 in a monthFDA label
Taken as needed rather than on a schedule, but the label sets a hard ceiling on frequency because of transient blood pressure rises and skin darkening with repeat dosing. That ceiling is the closest thing to a cycling rule here, and it is a real one.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
Your draw
35 / 100 unitsHow do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized PT-141 (Bremelanotide) keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Who should avoid it
- Uncontrolled high blood pressure
- Known cardiovascular disease
- Pregnancy
Stop and get help
- Chest pain or a severe headache with a racing heart
- An erection lasting more than four hours, which is a medical emergency
- Signs of an allergic reaction
Common effects
- Nausea, which is the most common effect
- A temporary rise in blood pressure and drop in heart rate
- Flushing and headache
- Darkening of skin or gums with repeated use
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is PT-141 (Bremelanotide) approved?
And where the numbers on this page come from.Yes. FDA-approved.
A regulator reviewed the evidence and cleared it for specific uses.
- DoseFrom the drug label. The manufacturer tested this range and a regulator reviewed it.
- Vial sizeFrom what vendors typically list; not a recommendation.
- Sources
- Reviewed22 July 2026
What else is like PT-141 (Bremelanotide)?
Others in Sexual and hormonal, side by side.If you're weighing PT-141 (Bremelanotide), it's worth reading Kisspeptin, Gonadorelin (GnRH), and HCG (Human Chorionic Gonadotropin) in the same class.
An approved shot that boosts sexual desire through the brain.
- Dose
- 1.75 mg per dose
- How often
- As needed, before activity
A peptide that switches on natural sex-hormone signaling for libido and fertility.
- Dose
- Varies (research)
- How often
- As studied
A shot that keeps your own testosterone and fertility hormones going.
- Dose
- 0.1 up to 0.2 mg per dose (start low, increase slowly)
- How often
- 2-3x per week or more
A hormone shot that keeps the testicles making testosterone and sperm.
- Dose
- 250 up to 500 IU per dose (alongside testosterone therapy)
- How often
- 2-3x per week
10What these words mean
Show glossary +
What these words mean
- Titrate
- Starting at a low dose and increasing it slowly over time so your body adjusts and side effects stay mild.
- Subcutaneous
- An injection just under the skin, into the fat layer, usually with a short, thin insulin needle.
- Intramuscular (IM)
- An injection into a muscle, using a longer needle.
- Reconstitution
- Mixing a powdered peptide with liquid (bacteriostatic water) so it can be drawn into a syringe.
- Bacteriostatic water
- Sterile water with a tiny amount of preservative, used to mix powdered peptides.
- Concentration
- How strong the mixed peptide is, in milligrams per milliliter (mg/mL). More water makes it weaker; less water makes it stronger.
- Units (on the syringe)
- The marks on an insulin syringe. 100 units equals 1 mL. They measure how much liquid you draw, not the dose in milligrams.
- mcg and mg
- Units of dose. 1 milligram (mg) equals 1,000 micrograms (mcg).
- GLP-1
- A natural gut hormone that lowers appetite and blood sugar. Drugs that copy it, like semaglutide, are used for weight loss.
- Growth hormone secretagogue
- A compound that nudges your body to release more of its own growth hormone, rather than injecting the hormone itself.
- Half-life
- How long a compound stays active in your body. A longer half-life means you inject less often.
- Peptide vs small molecule
- A peptide is a short chain of amino acids. A few items here (like MK-677 or methylene blue) are small molecules, not true peptides, but people use them the same way.
- Research only
- No approved dose or use in people. Sold for research and not reviewed by the FDA for safety or quality.
- Investigational
- Still being tested in clinical trials and not yet approved or legally sold for general use.
- Banned in drug-tested sport
- Prohibited by the World Anti-Doping Agency (WADA); using it can disqualify a competing athlete.
Sources
- FDA prescribing information, Vyleesi(2019)FDA approval for low sexual desire in premenopausal women.
Last reviewed 22 July 2026