Dermorphin_Dosage, benefits & legal status
Also known as frog juice, Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser
A frog-skin opioid many times stronger than morphine, best known from horse racing scandals.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Dermorphin?
Plain language first. The technical label stays, but it never stands alone.Overview
An opioid from frog skin, much stronger than morphine, with no medical use and a history in horse doping. It sits in vendor catalogues next to recovery peptides and does not belong there.
H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2, a heptapeptide isolated from Phyllomedusa frog skin. Highly selective mu-opioid receptor agonist with reported potency substantially exceeding morphine on a molar basis. The D-alanine at position 2 confers resistance to enzymatic degradation.
What it's used for
Studied as a research tool for opioid receptor biology. It has no approved medical use and is best known as a horse-doping agent.
How does Dermorphin work?
What it does in the body, and where.This is an opioid, and everything that follows from that applies.
- 01It acts on the same receptor as morphineDermorphin is a mu-opioid receptor agonist with high selectivity for that receptor over the others in the family.
- 02It is far more potent by weightReported potency is many times that of morphine on a milligram basis, which is what makes dosing errors dangerous rather than merely wasteful.
- 03An unusual amino acid makes it durableThe sequence contains a D-form amino acid, which is rare in natural peptides and slows enzymatic breakdown considerably.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Research tool for studying mu-opioid receptor biologyResearch only
- Pain, as a research question onlyResearch only
- Performance enhancement in racehorses, where it has been detected and prosecutednone
The published record
Papers and trials about Dermorphin
53 papers tagged human · 37 not reviews or lab · 0 clinical trial publications
Furthest stage reached: No clinical trial on record
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count. 438 papers and 0 trials indexed in detail.
At a glance
Four things to know about Dermorphin
Evidence
Category
Brain, mood and sleep
Common vial
5 mg
Half-life
Nothing published in humans
How much, and do you cycle it?
The range, and whether you take breaks.Research only, varies. No established pattern No range
No published human study establishes a schedule.
Nothing published in humansNo figure
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Human research exposure was about 0.16 mg/kg IV in 1980s experiments. This is a potent opioid with no approved or established therapeutic dose, so we do not show a usable range.
How do you store it?
Before mixing, and after.Dry powder in the freezer or fridge. Once mixed, fridge, and use within about a month.
Unmixed lyophilized Dermorphin keeps for a long time cold. Once you add water the clock starts: most reconstituted vials hold up for roughly 28 to 30 days at fridge temperature. Keep it out of light, and do not freeze it after mixing.
What are the side effects and cautions?
Known cautions and warnings for this compound.Solubility, computed: 29% charged residues, 43% hydrophobic. Water usually sufficient.
A first-pass rule from peptide manufacturers' guidance. It does not account for disulfide bridges, salt form or how the powder was dried, and it predicts what should be easy rather than what will happen in your vial.
Who should avoid it
- Any non-laboratory use
- Any concurrent opioid, sedative or alcohol use
- Any respiratory condition
- Pregnancy or breastfeeding
- A history of substance use disorder
Stop and get help
- Slowed or shallow breathing, which is the way opioids kill
- Extreme drowsiness or unresponsiveness
- Any of the above in another person after exposure
Common effects
- Carries the full risk profile of a potent opioid, including respiratory depression, dependence and overdose.
- Potency well above morphine means the margin for a dosing error is correspondingly smaller.
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Dermorphin approved?
And where the numbers on this page come from.No. Dermorphin is not approved for any use, anywhere. It is sold labeled for laboratory research only, and there is no legal route to buy it for human use.
- Approval statusResearch only
- RouteUnder the skin (subcutaneous)
- Checked24 August 2026
- DoseFrom published human studies. Not approved by a regulator for this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesNone traced yet.
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
You can compare this against the whole library, or read how to check a seller.
What else is like Dermorphin?
Others in Brain, mood and sleep, side by side.If you're weighing Dermorphin, it's worth reading GB-115, P7C3, and Phenibut in the same class.
A frog-skin opioid many times stronger than morphine, best known from horse racing scandals.
- Dose
- Research only
- How often
- Varies
A Russian anti-anxiety dipeptide that blocks a panic receptor instead of sedating you.
- Dose
- 1 mg per day in the published human study
- How often
- Daily in the study
A neuroprotective molecule from a mouse screen. Never given to a person.
- Dose
- Research only
- How often
- No established pattern
A Russian anxiety drug sold as a nootropic. Stopping it suddenly can be dangerous.
- Dose
- No safe self-directed dose is established
- How often
- Not daily, if at all
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
- How to Vet a Peptide Vendor
Independent COAs, HPLC purity, and the red flags that mean walk away.
Sources
No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence
Beyond these, 438 records are indexed. Browse the records