Zovaglutide (ZT-002)_Dosage, benefits & legal status
Also known as ZT-002, Zovaglutide
An experimental once-a-month weight-loss shot.
Common vial size is what vendors typically sell, not a recommendation. Enter your own vial in the calculator.
What is Zovaglutide (ZT-002)?
Plain language first. The technical label stays, but it never stands alone.Overview
What it's used for
An experimental once-a-month weight-loss shot, with about 14% loss in early testing.
How does Zovaglutide (ZT-002) work?
What it does in the body, and where.Zovaglutide is a GLP-1 agonist engineered to last long enough for monthly dosing.
- 01Standard GLP-1 receptor activationNothing unusual about the mechanism itself.
- 02The difference is how long it circulatesLong enough to inject once every four weeks rather than weekly, which is a meaningful difference in adherence over years.
- 03Investigational, and data so far is from conference presentationsPhase 2 results were presented at EASD in 2025. Treat as provisional until published.
What else is it used for?
Each use below carries its own evidence level. Approved means regulators have cleared it for that purpose. Investigational means it is in trials. Early research means it is being studied and is not established.
- Weight loss with once-a-month dosingInvestigational
The published record
Papers and trials about Zovaglutide (ZT-002)
Searched: Zovaglutide, ZT-002.
10 papers tagged human · 0 not reviews or lab · 0 clinical trial publications
10 registered trials · none with posted results
Furthest stage reached: Phase 3, under way
Counted from Europe PMC indexing, not read by a person; a human tag can land on reviews, commentary or lab papers; clinical trial publications is the narrower count.
At a glance
Four things to know about Zovaglutide (ZT-002)
Evidence
Investigational
Category
Weight loss and metabolic
Common vial
Varies
Half-life
About 11 days
How much, and do you cycle it?
The range, and whether you take breaks.80 up to 160 mg per month (trial doses), monthly. Not cycled in the trials Trial dose
Given continuously for the whole study period: HORIZON-1, 52 weeks. The dose is stepped up at the start, which is a ramp rather than a cycle, and no trial in this class built in a planned break.
About 11 daysTrial protocol
Dosed once a month.
Source: First-in-human single ascending dose study, ADA 2024 abstract 119-OR
You can compare this against the whole library to see where it sits.
How do I dose and price it?
Enter your vial and your dose. Pick a mix. We show the draw and the cost.The vial holds a fixed amount of drug. Adding more water does not make more drug, it just spreads it thinner, so you draw a bigger number on the syringe for the same dose.
Choose your mix
Measuring the water1 mL = one full 100-unit syringe.
How do you store it?
Before mixing, and after.Nothing to store: it is not sold anywhere.
Zovaglutide (ZT-002) has never been marketed, so there is no vial, pen or bottle to keep at home. Supplies for a trial are made, stored and dispensed by the sponsor and the trial pharmacy under conditions set in the protocol. Anything offered for sale under this name did not come from that supply chain.
What are the side effects and cautions?
Known cautions and warnings for this compound.This compound is in clinical trials and is not sold in a standard vial, so there is no common vial size to show. Trial doses are given as prepared by the study, and the reconstitution calculator does not apply. Doses up to 160 mg a month are sixteen times the 10 mg reference vial.
Who should avoid it
- No formal contraindications established
- Pregnancy
Stop and get help
- Vomiting badly enough that you cannot keep fluids down
- Severe stomach pain that spreads to your back
- Signs of an allergic reaction such as face or throat swelling, hives, or trouble breathing
Common effects
- Stomach effects typical of this drug family
- Detailed figures have not been published in a peer-reviewed journal, only presented at a conference
Where this page says nothing is established, that means nobody has studied it, not that a compound is safe.
Is Zovaglutide (ZT-002) approved?
And where the numbers on this page come from.No. Zovaglutide (ZT-002) is not approved anywhere and is currently in company-run clinical trials. There is no legal route to obtain it outside a trial.
- Approval statusInvestigational
- RouteUnder the skin (subcutaneous)
- Checked14 August 2026
- DoseFrom published clinical trials. Not approved by a regulator for this dose.
- Vial sizeFrom what vendors typically list; not a recommendation.
- SourcesNone traced yet.
What has happened recently
We have not yet written a full regulatory note for this compound. The status above is current as of the date shown.
You can compare this against the whole library, or read how to check a seller.
What else is like Zovaglutide (ZT-002)?
Others in GLP-1 agonists, side by side.If you're weighing Zovaglutide (ZT-002), it's worth reading Retatrutide, Tirzepatide, and Semaglutide in the same class.
An experimental once-a-month weight-loss shot.
- Dose
- 80 up to 160 mg per month (trial doses)
- How often
- Monthly
An experimental weekly shot with some of the biggest weight-loss numbers yet in trials.
- Dose
- 1 up to 12 mg per dose (start low, increase slowly)
- How often
- Weekly
The drug in Mounjaro and Zepbound: a weekly shot for major weight loss and blood sugar.
- Dose
- 2.5 up to 15 mg per week (start low, increase slowly)
- How often
- Weekly
The drug in Ozempic and Wegovy: a weekly shot that curbs hunger for steady weight loss.
- Dose
- 0.25 up to 2.4 mg per week (start low, increase slowly)
- How often
- Weekly
Guides for this compound
- How to Reconstitute a Peptide
Mix peptide powder with bacteriostatic water, step by step.
- How to Read an Insulin Syringe
Read the units, convert to millilitres, and draw the exact dose.
- mcg vs mg: The Peptide Dosing Mistake to Avoid
Your vial says mg and your protocol says mcg. Here is the conversion and how to check it.
- Why Does My Peptide Injection Itch or Welt
Injection-site irritation, a histamine reaction, or a true allergy, and how to tell them apart.
- How to Read a Peptide COA
What the purity number does and does not tell you, and how to spot an edited report.
Sources
No primary source has been traced for this compound yet. Treat everything on this page as unverified until one is. How we grade evidence
Beyond these, 10 records are indexed. Browse the records